PM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1/NOX4 pathways

scientific article published on 30 September 2020

PM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1/NOX4 pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-020-72629-9
P932PMC publication ID7527517
P698PubMed publication ID32999298

P2093author name stringHyunsu Bae
Jee-Youn Kim
Jaeho Cho
Jin-Mo Kim
Yoo Jin Jung
Byeong Rok Yoo
Song Yee Han
Sung-Hyo Park
P2860cites workRadiation induced lung injury: prediction, assessment and managementQ26862810
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Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosisQ28385018
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TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?Q33913350
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Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanismsQ36634373
Radiation injury of the lung after stereotactic body radiation therapy (SBRT) for lung cancer: a timeline and pattern of CT changesQ37643010
Pro-apoptotic Noxa is involved in ablative focal irradiation-induced lung injuryQ37693407
Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in MiceQ37712927
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Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCNQ39412554
Sustained expression of NADPH oxidase 4 by p38 MAPK-Akt signaling potentiates radiation-induced differentiation of lung fibroblastsQ39714199
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CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosisQ42185579
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Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibitionQ42905112
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Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trialQ44707469
Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.Q44937602
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.Q45971622
Efficacy of a traditional Korean medicine, Chung-Sang-Bo-Ha-Tang, in a murine model of chronic asthmaQ47297659
High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model.Q47585829
Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancerQ47862662
Role of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis.Q51711774
HSP27 inhibitor attenuates radiation-induced pulmonary inflammation.Q52727764
A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-β1 pathwayQ59340341
A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosisQ71977062
Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosisQ72254421
Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitisQ73153257
TGF-beta, radiation-induced pulmonary injury and lung cancerQ73802916
Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalationQ74453872
Molecular and cellular basis of radiation fibrosisQ74546766
A preclinical rodent model of acute radiation-induced lung injury after ablative focal irradiation reflecting clinical stereotactic body radiotherapyQ88096581
The Hsp27-Mediated IkBα-NFκB Signaling Axis Promotes Radiation-Induced Lung FibrosisQ92281455
Radiation-Induced Lung Injury: Assessment and ManagementQ93178456
P433issue1
P921main subjectpulmonary fibrosisQ32446
P304page(s)16112
P577publication date2020-09-30
P1433published inScientific ReportsQ2261792
P1476titlePM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1/NOX4 pathways
P478volume10

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