Inherited causes of clonal haematopoiesis in 97,691 whole genomes

scientific article published on 14 October 2020

Inherited causes of clonal haematopoiesis in 97,691 whole genomes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41586-020-2819-2
P698PubMed publication ID33057201

P50authorEric LanderQ970550
JoAnn E. MansonQ6204013
Lawrence F BielakQ104501810
Rasika A MathiasQ114270919
May E MontasserQ114332681
Stella AslibekyanQ114367812
Erin J ButhQ114440179
Leslie A. LangeQ115055812
Andrew D. JohnsonQ124721130
Gonçalo AbecasisQ16001382
Sekar KathiresanQ28050074
Eric BoerwinkleQ28050857
Charles KooperbergQ28360449
Cecelia A LaurieQ87946820
Cathy LaurieQ87946824
Susan R HeckbertQ88077554
Sharon L R KardiaQ88218091
Daniel LevyQ88264418
Nicholette D PalmerQ88464225
Donna K ArnettQ88878357
Steven A LubitzQ88968134
Jee-Young MoonQ89095114
Wayne Huey-Herng SheuQ89111214
Stephen S RichQ89207378
Tasha E FingerlinQ89288019
Kent D TaylorQ89467237
Edwin K SilvermanQ89513458
Joshua WeinstockQ89768656
Laura RaffieldQ89849173
Charles P FulcoQ90117882
Nicholas RafaelsQ90182629
Hongyu ZhaoQ90573050
Benjamin L. EbertQ91044165
Xiuqing GuoQ91917940
Patricia A PeyserQ91917947
Donald W BowdenQ92206005
Tanika N KellyQ92206021
James G. WilsonQ92206045
Alexander P ReinerQ92206050
Lewis BeckerQ93159604
Kathleen C BarnesQ97535059
Michelle DayaQ98240643
Jai G BroomeQ98665269
Paul L AuerQ99370519
Xiaotian LiaoQ100560169
Jessica Lasky-SuQ30002011
Albert V. SmithQ30348342
Braxton D. MitchellQ30348346
Ramachandran S. VasanQ30348351
Bruce M. PsatyQ30429993
Myriam FornageQ30436602
Scott T WeissQ59167048
Esteban BurchardQ59752810
Jerome I RotterQ59813011
Stephen McGarveyQ60055486
Michael H ChoQ63385219
Susan RedlineQ64755281
John BlangeroQ66732805
Lenore J LaunerQ66739234
Barry FreedmanQ67485116
Jennifer A SmithQ37629351
L. Adrienne CupplesQ37638868
Yi-Cheng ChangQ37639369
Dawood DarbarQ38327125
Mariza de AndradeQ42067404
Daniel E. WeeksQ42796650
Joshua C BisQ79326643
Joanne E. CurranQ80157322
Jacob O KitzmanQ82212221
Mindy D SzetoQ84582670
Kari E NorthQ85938878
Russell P TracyQ86752125
Ester SabinoQ87399923
Eric A WhitselQ87625401
Jill M JohnsenQ87636121
Marguerite R IrvinQ87769958
François AguetQ87780466
Ivana YangQ87827387
Erik L BaoQ49309085
Pradeep NatarajanQ55163360
Stephanie M. GogartenQ55426348
Vijay G SankaranQ56204355
Seyedeh M ZekavatQ56343454
Brian E CadeQ56524937
Jesse EngreitzQ56905799
James HixsonQ57010699
Eimear E KennyQ57317463
Angel C MakQ57324472
Alexander G. BickQ57613503
Patrick T EllinorQ57775928
Barbara A KonkleQ58051615
Ruth J. LoosQ58867501
Dan RodenQ58973971
P2093author name stringAdolfo Correa
Bruce D Levy
Dabeeru C Rao
Nicholas L Smith
Siddhartha Jaiswal
Deborah A Meyers
Yongmei Liu
Robert C Kaplan
David A Schwartz
Paul Scheet
Sebastian M Armasu
Lifang Hou
John A Heit
L Keoki Williams
Hemant K Tiwari
Jiang He
Sally E Wenzel
Quenna Wong
Jiwon Lee
Thomas W Blackwell
Brian Custer
James S Floyd
Satish K Nandakumar
Marsha M Wheeler
Fei Fei Wang
Arden Moscati
M Benjamin Shoemaker
Margaret A Taub
Kristin Ardlie
Christopher J Gibson
Pinkal Desai
Kyle Chang
Hongsheng Gui
Priyadarshini Kachroo
Joseph Nasser
Juan M Peralta
Ethan Lange
Amy E Lin
Peter Durda
Bala Bharathi Burugula
Matthew J Leventhal
NHLBI Trans-Omics for Precision Medicine Consortium
Ida Yii-Der Chen
P2860cites workSequencing of 53,831 diverse genomes from the NHLBI TOPMed ProgramQ105665221
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed ProgramQ124796917
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypesQ24635938
A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasmsQ27851467
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequenceQ28385712
Age-related clonal hematopoiesis associated with adverse outcomesQ28386602
Age-related mutations associated with clonal hematopoietic expansion and malignanciesQ28387160
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromesQ28392451
Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarismQ88605919
Somatic mutations precede acute myeloid leukemia years before diagnosisQ89486407
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studiesQ90929505
Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal HematopoiesisQ91213509
Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbationsQ91560371
A statistical framework for cross-tissue transcriptome-wide association analysisQ91908163
The ENCODE Blacklist: Identification of Problematic Regions of the GenomeQ93088733
The mutational constraint spectrum quantified from variation in 141,456 humansQ95933932
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cellsQ100560178
Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasmsQ28392728
Mosaic loss of chromosome Y is associated with common variation near TCL1AQ28393244
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformationQ28508217
Adjusting batch effects in microarray expression data using empirical Bayes methodsQ29614937
STAR: ultrafast universal RNA-seq alignerQ29615052
Fitting Linear Mixed-Effects Models Using lme4Q30477923
DNA methylation arrays as surrogate measures of cell mixture distributionQ30530775
An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence dataQ30934831
FINEMAP: efficient variable selection using summary data from genome-wide association studiesQ31037165
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasmsQ33383709
Red cell distribution width and mortality in older adults: a meta-analysisQ33654608
Landscape of somatic mutations in 560 breast cancer whole-genome sequencesQ34046731
CpGassoc: an R function for analysis of DNA methylation microarray dataQ34208767
RNA-SeQC: RNA-seq metrics for quality control and process optimizationQ34249292
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samplesQ34327021
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation.Q34347773
Geroscience: linking aging to chronic diseaseQ34449096
HIV-1 Infection Accelerates Age According to the Epigenetic ClockQ34476144
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adultsQ34538007
Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.Q34548829
CHEK2 is a multiorgan cancer susceptibility geneQ34551970
System for Quality-Assured Data Analysis: Flexible, reproducible scientific workflows.Q64915998
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderlyQ34556382
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.Q34558126
Haplotype-based profiling of subtle allelic imbalance with SNP arraysQ36490003
Clock-like mutational processes in human somatic cellsQ36666868
Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variationQ36800445
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancerQ36897003
Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-κB activity and increases drug resistance in multiple myelomaQ47253158
Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease.Q50093911
Clonal Hematopoiesis and Evolution to Hematopoietic MalignanciesQ50209900
A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.Q51768323
MutationalPatterns: comprehensive genome-wide analysis of mutational processes.Q55078547
Deep-coverage whole genome sequences and blood lipids among 16,324 individualsQ56333979
Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projectsQ57048739
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterationsQ57178727
Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemiaQ57319909
P921main subjecthemopoiesisQ919283
P577publication date2020-10-14
P1433published inNatureQ180445
P1476titleInherited causes of clonal haematopoiesis in 97,691 whole genomes

Reverse relations

cites work (P2860)
Q112290018ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing
Q112288965Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients
Q112842174Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases
Q115778783Blood’s life history traced through genomic scars
Q110596206Clonal dynamics of hematopoietic stem cell compartment in aplastic anemia
Q112611325Clonal hematopoiesis associated with epigenetic aging and clinical outcomes
Q103837522Clonal hematopoiesis is associated with risk of severe Covid-19
Q104064346Common germline-somatic variant interactions in advanced urothelial cancer
Q125346629Discovering the drivers of clonal hematopoiesis
Q112286602Distinction of lymphoid and myeloid clonal hematopoiesis
Q115055902From GWAS variant to function: A study of ∼148,000 variants for blood cell traits
Q112639485Genome-wide enhancer maps link risk variants to disease genes
Q112235559High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster
Q101565642Increased CHIP Prevalence Amongst People Living with HIV
Q114872479Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection
Q114873133Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders
Q100560178Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Q112586492Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level
Q115777985Life histories of myeloproliferative neoplasms inferred from phylogenies
Q112812066Liquid biopsy enters the clinic — implementation issues and future challenges
Q114872553Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities
Q110357071Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein
Q101453663Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women
Q124796917Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Q112724209The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Q118640287The emerging importance and evolving understanding of clonal hematopoiesis in multiple myeloma
Q115778774The longitudinal dynamics and natural history of clonal haematopoiesis
Q113897505Understanding Normal and Pathological Hematopoietic Stem Cell Biology Using Mathematical Modelling
Q115223203Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program