Quantitative dissection of transcription in development yields evidence for transcription factor-driven chromatin accessibility

scientific article published on 19 October 2020

Quantitative dissection of transcription in development yields evidence for transcription factor-driven chromatin accessibility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.56429
P932PMC publication ID7738189
P698PubMed publication ID33074101

P50authorJonathan LiuQ92266888
Hernan G. GarciaQ100731065
Shelby A. BlytheQ38642209
P2093author name stringElizabeth Eck
Maryam Kazemzadeh-Atoufi
Sydney Ghoreishi
P2860cites workDirect measurement of transcription factor dissociation excludes a simple operator occupancy model for gene regulationQ54294539
Combinatorial Gene Regulation through Kinetic Control of the Transcription Cycle.Q55085098
The Quasi-Steady-State Assumption: A Case Study in PerturbationQ56210926
Diverse Spatial Expression Patterns Emerge from Unified Kinetics of Transcriptional BurstingQ58593977
Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubsQ59792536
Dynamic multifactor hubs interact transiently with sites of active transcription in embryosQ60931061
Mechanism of protein access to specific DNA sequences in chromatin: a dynamic equilibrium model for gene regulationQ71566510
Evolutionary and functional insights into the mechanism underlying body-size-related adaptation of mammalian hemoglobinQ83227653
Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativityQ83232121
Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene ExpressionQ91989068
Multimodal transcriptional control of pattern formation in embryonic developmentQ92286420
Predictive shifts in free energy couple mutations to their phenotypic consequencesQ92882061
The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional OutputQ93080488
Gene Regulation in and out of EquilibriumQ94571912
Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transitionQ21563380
Physics of chemoreceptionQ24546294
Progression of the cell cycle through mitosis leads to abortion of nascent transcriptsQ24642939
A genomic code for nucleosome positioningQ24650238
Interplay between positive and negative activities that influence the role of Bicoid in transcriptionQ24813834
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODELQ27861036
Trade-offs and constraints in allosteric sensingQ28477808
Thermodynamic State Ensemble Models of cis-RegulationQ28481731
Localization of ASH1 mRNA particles in living yeastQ29614818
Identifying DNA and protein patterns with statistically significant alignments of multiple sequencesQ29615307
Mutations of the Drosophila zinc finger-encoding gene vielfältig impair mitotic cell divisions and cause improper chromosome segregationQ30477157
Stability and nuclear dynamics of the bicoid morphogen gradientQ30481327
Foundations for engineering biologyQ30482962
Decision making at a subcellular level determines the outcome of bacteriophage infectionQ30494599
Statistical mechanics of Monod-Wyman-Changeux (MWC) modelsQ30547523
The transcription factor titration effect dictates level of gene expressionQ30582620
Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryosQ30585347
Discrimination between thermodynamic models of cis-regulation using transcription factor occupancy dataQ30703913
Analysis of combinatorial cis-regulation in synthetic and genomic promotersQ33386730
Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resourcesQ33551343
Thermodynamics-Based Models of Transcriptional Regulation by Enhancers: The Roles of Synergistic Activation, Cooperative Binding and Short-Range RepressionQ33700661
On schemes of combinatorial transcription logicQ33711386
Zelda potentiates morphogen activity by increasing chromatin accessibilityQ33821232
Temporal coordination of gene networks by Zelda in the early Drosophila embryo.Q34058205
Transcriptional Enhancers in Animal Development and EvolutionQ34137394
Living without 30nm chromatin fibersQ34142094
Quantitative model for gene regulation by lambda phage repressorQ34261203
Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promotersQ34276083
Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional ActivityQ34364634
Nucleosome-mediated cooperativity between transcription factorsQ34450175
Chemosensing in Escherichia coli: two regimes of two-state receptorsQ34478548
Tuning promoter strength through RNA polymerase binding site design in Escherichia coliQ34524579
Precision of Hunchback Expression in the Drosophila EmbryoQ34639257
Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogasterQ34645803
A gradient of bicoid protein in Drosophila embryosQ34687844
The nonequilibrium mechanism for ultrasensitivity in a biological switch: sensing by Maxwell's demonsQ34805576
A framework for modelling gene regulation which accommodates non-equilibrium mechanismsQ34887134
Multiple sequence-specific factors generate the nucleosome-depleted region on CLN2 promoter.Q35058171
Quantitative dissection of the simple repression input-output functionQ35123050
The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativityQ35153238
Establishment of regions of genomic activity during the Drosophila maternal to zygotic transitionQ35173164
Transcriptional regulatory cascades in development: initial rates, not steady state, determine network kineticsQ35234604
The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor bindingQ35557755
Pattern Formation by Graded and Uniform Signals in the Early Drosophila EmbryoQ35743239
Combining protein and mRNA quantification to decipher transcriptional regulationQ35907776
Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryoQ35942104
A Systematic Ensemble Approach to Thermodynamic Modeling of Gene Expression from Sequence Data.Q36005275
Transcriptional regulation by the numbers: models.Q36083228
Transcriptional regulation by the numbers: applicationsQ36083233
Precision of Readout at the hunchback Gene: Analyzing Short Transcription Time Traces in Living Fly EmbryosQ36220219
A model of spatially restricted transcription in opposing gradients of activators and repressorsQ36321629
A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genesQ36503786
Gene regulation by chromatin structure: paradigms established in Drosophila melanogasterQ36553584
Mitotic Repression of RNA Polymerase II Transcription Is Accompanied by Release of Transcription Elongation ComplexesQ36573020
Enhancer-like long-range transcriptional activation by λ CI-mediated DNA loopingQ36637492
Chromatin decouples promoter threshold from dynamic rangeQ36732068
Operator Sequence Alters Gene Expression Independently of Transcription Factor Occupancy in BacteriaQ36739284
Dynamic interpretation of maternal inputs by the Drosophila segmentation gene networkQ36799112
Quantitative perturbation-based analysis of gene expression predicts enhancer activity in early Drosophila embryoQ36879251
Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyiQ36980333
The zinc-finger protein Zelda is a key activator of the early zygotic genome in DrosophilaQ37003783
A quantitative model of transcription factor-activated gene expressionQ37226832
Eukaryotic transcriptional dynamics: from single molecules to cell populationsQ37253556
Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterningQ37308421
Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in DrosophilaQ37666396
Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperativeQ38298166
Using the MWC model to describe heterotropic interactions in hemoglobin.Q38632051
Measurement of gene regulation in individual cells reveals rapid switching between promoter statesQ39466038
Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputsQ39738882
Collaborative competition mechanism for gene activation in vivoQ39740430
Sensitivity of OR in phage lambdaQ40269296
The co-activator CREB-binding protein participates in enhancer-dependent activities of bicoidQ40516931
Mitotic repression of the transcriptional machinery.Q41516335
Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis.Q41809122
Incorporating nucleosomes into thermodynamic models of transcription regulationQ41909104
Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo.Q42025274
Probing the limits to positional informationQ42078954
Information Integration and Energy Expenditure in Gene RegulationQ42180396
Concentration dependent chromatin states induced by the bicoid morphogen gradientQ42273867
Thermodynamic models of combinatorial gene regulation by distant enhancersQ43493950
Computational models for neurogenic gene expression in the Drosophila embryo.Q46006127
The role of DNA sequence in nucleosome breathing.Q46237278
A conserved maternal-specific repressive domain in Zelda revealed by Cas9-mediated mutagenesis in Drosophila melanogaster.Q47271393
Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene RegulationQ49895264
Live imaging of bicoid-dependent transcription in Drosophila embryos.Q50714696
Predicting expression patterns from regulatory sequence in Drosophila segmentationQ51897395
Dynamic control of positional information in the early Drosophila embryo.Q51994119
DNA looping and physical constraints on transcription regulation.Q52010688
Identification of consensus patterns in unaligned DNA sequences known to be functionally relatedQ52241864
Parameters controlling transcriptional activation during early Drosophila developmentQ52451717
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogenQ52452949
The gradient morphogen bicoid is a concentration-dependent transcriptional activatorQ52453670
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryoQ52456769
Cytoarchitecture and the patterning of fushi tarazu expression in the Drosophila blastodermQ52459337
Estrogen-dependent control and cell-to-cell variability of transcriptional bursting.Q52687717
Tuning Transcriptional Regulation through Signaling: A Predictive Theory of Allosteric InductionQ52724460
cis Determinants of Promoter Threshold and Activation Timescale.Q53382572
P577publication date2020-10-19
P1433published ineLifeQ2000008
P1476titleQuantitative dissection of transcription in development yields evidence for transcription factor-driven chromatin accessibility
P478volume9

Reverse relations

Q112700505Differential regulation of alternative promoters emerges from unified kinetics of enhancer-promoter interactioncites workP2860

Search more.