MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk

scientific article published on 23 October 2020

MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41467-020-17315-0
P698PubMed publication ID33097703

P50authorIda SurakkaQ29839641
Daníel F. GuðbjartssonQ30348313
Unnur StyrkarsdottirQ30430779
Cristen J. WillerQ37389746
Bjørn Olav ÅsvoldQ41607561
Lars G FritscheQ47452535
Jonas B NielsenQ56952461
Brooke N WolfordQ57165299
Haocheng LuQ87693541
Sarah E GrahamQ89112636
Seunggeun LeeQ89748680
Aris BarasQ91062999
Wei ZhouQ91290466
Hilma HolmQ100958443
P2093author name stringKari Stefansson
Y Eugene Chen
Hyun Min Kang
Goncalo R Abecasis
Kristian Hveem
Arnulf Langhammer
Jack A Kosmicki
Maiken E Gabrielsen
Siri Forsmo
Regeneron Genetics Center
Anne Heidi Skogholt
Ben Brumpton
Joshua Backman
P2860cites workTwenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studiesQ24289320
MEPE, a new gene expressed in bone marrow and tumors causing osteomalaciaQ24290092
Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in boneQ28586605
Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone massQ28589622
Whole-genome sequencing identifies EN1 as a determinant of bone density and fractureQ30278692
Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulatorQ33643995
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Long-term risk of incident vertebral fracturesQ34731698
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Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.Q40059056
Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels.Q40061670
Evidence of downregulation of matrix extracellular phosphoglycoprotein during terminal differentiation in human osteoblastsQ40532879
Use of anti-osteoporotic drugs in central Norway after a forearm fractureQ40580195
The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twinsQ40943137
Two Rare Mutations in the COL1A2 Gene Associate With Low Bone Mineral Density and Fractures in IcelandQ41520420
Cohort Profile: the HUNT Study, NorwayQ44130322
Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysisQ44178324
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traitsQ44274525
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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation studyQ56888027
Genetic Variation in Bone Mineral Density and Calcaneal Ultrasound: A Study of the Influence of Menopause Using Female TwinsQ60692422
An atlas of genetic influences on osteoporosis in humans and miceQ60702246
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fracturesQ64068876
Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture.Q64899349
Comparison of Bone Mineral Densitometry at 2 Sites Versus 3 Sites in Patients Suspicious for Osteoporosis.Q64957818
Effect of inhaled corticosteroids on forearm bone mineral density: the HUNT study, NorwayQ80157211
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studiesQ90929505
Treating osteoporosis to prevent fractures: current concepts and future developmentsQ91107530
P433issue1
P304page(s)4093
P577publication date2020-10-23
P1433published inNature CommunicationsQ573880
P1476titleMEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk
P478volume11

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