Current and emerging therapies for coeliac disease

scientific article published on 20 November 2020

Current and emerging therapies for coeliac disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41575-020-00378-1
P698PubMed publication ID33219355

P50authorAlberto CamineroQ92682335
Maria Ines Pinto-SanchezQ38641226
Jason Tye-dinQ43120880
Katri LindforsQ88982962
P2093author name stringDaniel A Leffler
Laura Kivelä
P2860cites workRefractory Celiac DiseaseQ90416510
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Masked bolus gluten challenge low in FODMAPs implicates nausea and vomiting as key symptoms associated with immune activation in treated coeliac diseaseQ91460267
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Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.Q33765990
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Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial.Q35655989
Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease.Q35760432
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Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study.Q36174419
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Regulation of the activities of the mammalian transglutaminase family of enzymesQ36620140
Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac diseaseQ36675105
Addressing proteolytic efficiency in enzymatic degradation therapy for celiac diseaseQ37144602
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Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort studyQ37210839
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Celiac Disease and Anorexia Nervosa: A Nationwide StudyQ38756452
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studiesQ38785121
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Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease.Q38956502
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Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twinsQ39747742
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.Q40254093
Unexpected role of surface transglutaminase type II in celiac diseaseQ40351852
Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and ImmunogenicityQ40627090
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Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptidesQ42508921
Can an increase in celiac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding?Q43246606
T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminaseQ43682637
Larazotide acetate regulates epithelial tight junctions in vitro and in vivo.Q44417399
Body mass index and the risk of obesity in coeliac disease treated with the gluten-free dietQ44489656
Safety, tolerability, and activity of ALV003: results from two phase 1 single, escalating-dose clinical trialsQ45256460
No Difference Between Latiglutenase and Placebo in Reducing Villous Atrophy or Improving Symptoms in Patients With Symptomatic Celiac DiseaseQ46323022
Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac diseaseQ46605448
Epitope-Specific Immunotherapy Targeting CD4-Positive T Cells in Celiac Disease: Safety, Pharmacokinetics, and Effects on Intestinal Histology and Plasma Cytokines with Escalating Dose Regimens of Nexvax2 in a Randomized, Double-Blind, Placebo-ContrQ47389065
AGY, a Novel Egg Yolk-Derived Anti-gliadin Antibody, Is Safe for Patients with Celiac DiseaseQ47596605
Latiglutenase Improves Symptoms in Seropositive Celiac Disease Patients While on a Gluten-Free DietQ47867778
Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac diseaseQ47982815
Outcome measures in coeliac disease trials: the Tampere recommendations.Q50026308
Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease.Q51449292
Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis.Q52650025
Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease.Q53444099
Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients.Q53572632
Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.Q55053101
Limited availability and higher cost of gluten-free foods.Q55054287
A commensal Bifidobacterium longum strain improves gluten-related immunopathology in mice through expression of a serine protease inhibitor.Q55262976
Clinical intervention using Bifidobacterium strains in celiac disease children reveals novel microbial modulators of TNF-α and short-chain fatty acidsQ56379208
The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating InflammationQ57174271
Gluten induces coeliac-like disease in sensitised mice involving IgA, CD71 and transglutaminase 2 interactions that are prevented by probioticsQ58006988
Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel TherapiesQ59813523
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2Q64099175
Gluten Free Wheat: Are We There?Q64102468
Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohortQ64238901
Persistent Economic Burden of the Gluten Free DietQ64257599
Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter TrialQ64261077
A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac diseaseQ79512572
Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods?Q81728996
Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative MechanismQ88148576
Disease-driving CD4+ T cell clonotypes persist for decades in celiac diseaseQ88660930
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac DiseaseQ89595607
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac diseaseQ89686918
E40, a novel microbial protease efficiently detoxifying gluten proteins, for the dietary management of gluten intoleranceQ90069005
Targeting the MHC Ligandome by Use of TCR-Like AntibodiesQ90211977
P921main subjectceliac diseaseQ11088
P577publication date2020-11-20
P1433published inNature Reviews Gastroenterology & HepatologyQ2108255
P1476titleCurrent and emerging therapies for coeliac disease

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