Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

scientific article published on 03 December 2020

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour is …
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scholarly articleQ13442814

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P356DOI10.1038/S41574-020-00438-1
P698PubMed publication ID33273729

P50authorChioma Izzi-EngbeayaQ88635401
Ali AbbaraQ55436989
Waljit S DhilloQ61085239
P2093author name stringAlexander N Comninos
Edouard G Mills
P2860cites workDoes Kisspeptin Belong to the Proposed RF-Amide Peptide Family?Q21131271
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Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and IIIQ24336866
Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesityQ24337677
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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54Q24685744
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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptorQ28198401
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54Q28206906
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Glucagon regulates hepatic kisspeptin to impair insulin secretionQ30406016
Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice.Q30407682
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The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior.Q30444271
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Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesityQ33808252
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Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26Q87895898
Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependentQ88213463
Molecular cloning, characterization and expression analysis of spexin in spotted scat (Scatophagus argus)Q88650442
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Spexin Modulates Functions of Rat Endocrine Pancreatic CellsQ89137062
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KISS1 in metastatic cancer research and treatment: potential and paradoxesQ90173564
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A role for placental kisspeptin in β cell adaptation to pregnancyQ90753795
Estradiol-Dependent and -Independent Stimulation of Kiss1 Expression in the Amygdala, BNST, and Lateral Septum of MiceQ90942987
Promoter methylation of galanin receptors as epigenetic biomarkers for head and neck squamous cell carcinomasQ91035053
Roux-en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexinQ91067918
Spexin/NPQ Induces FBJ Osteosarcoma Oncogene (Fos) and Produces Antinociceptive Effect against Inflammatory Pain in the Mouse ModelQ91143504
Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese ChildrenQ91181784
The role of galanin in the differentiation of mucosal mast cells in miceQ91207365
Intraperitoneal Treatment of Kisspeptin Suppresses Appetite and Energy Expenditure and Alters Gastrointestinal Hormones in MiceQ91292741
Decreased Spexin Levels in Patients with Type 1 and Type 2 DiabetesQ91299539
Kisspeptin-Activated Autophagy Independently Suppresses Non-Glucose-Stimulated Insulin Secretion from Pancreatic β-CellsQ91451785
Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with PrediabetesQ91530118
Spexin in the physiology of pancreatic islets-mutual interactions with insulinQ91864161
Galanin plays a role in antinociception via binding to galanin receptors in the nucleus accumbens of rats with neuropathic painQ91993435
Serum levels of spexin are increased in the third trimester pregnancy with gestational diabetes mellitusQ92165552
Galanin Signaling in the Brain Regulates Color Pattern Formation in ZebrafishQ92421851
Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weightQ92499112
Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotypeQ92818565
Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasisQ92938218
Galanin immunoreactivity is sexually polymorphic in neuroendocrine and vocal-acoustic systems in a teleost fishQ93012285
Overexpression of Spexin 1 in the Dorsal Habenula Reduces Anxiety in ZebrafishQ93046825
ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditureQ93178322
Central galanin stimulates pituitary prolactin secretion in rats: possible involvement of hypothalamic vasoactive intestinal polypeptideQ93511760
Chronic Social Defeat Stress Up-Regulates Spexin in the Brain of Nile Tilapia (Oreochromis niloticus)Q94592298
Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytesQ42826645
Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in miceQ42917738
Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones.Q43234172
Neurotransmissions of antidepressant-like effects of kisspeptin-13.Q44044369
Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestineQ44124318
Centrally administered galanin-like peptide modifies food intake in the rat: a comparison with galanin.Q44208798
A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouseQ44315330
Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogsQ44449314
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Loss-of-function mutation of the galanin gene is associated with perturbed islet function in miceQ44814498
Galanin-like peptide as a possible link between metabolism and reproduction in the macaqueQ44835046
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Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout StudyQ45057708
Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.Q45120757
Stimulation of sexual behavior in the male rat by galanin-like peptideQ45157274
A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus.Q45874920
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GPR54 peptide agonists stimulate insulin secretion from murine, porcine and human isletsQ46175432
Emerging Roles of Kisspeptin in Sexual and Emotional Brain ProcessingQ46312799
Central administration of galanin stimulates feeding behavior in chicks.Q46412545
PVN galanin increases fat storage and promotes obesity by causing muscle to utilize carbohydrate more than fat.Q46490364
Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreasQ46770082
Kisspeptin1 modulates odorant-evoked fear response via two serotonin receptor subtypes (5-HT1A and 5-HT2) in zebrafish.Q47074171
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.Q47289867
Changes in body weight during pharmacological treatment of depressionQ47418955
Maternally involved galanin neurons in the preoptic area of the rat.Q47420697
Female sexual behavior in mice is controlled by kisspeptin neuronsQ47548704
Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male miceQ47550512
Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in womenQ47579825
Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats.Q47628133
Modification of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist.Q47629988
Enhancement of the luteinising hormone surge by male olfactory signals is associated with anteroventral periventricular Kiss1 cell activation in female rats.Q47701506
Induction of galanin after chronic sertraline treatment in mouse ventral dentate gyrusQ47897750
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamusQ47900449
Infusion of galanin into the mid-caudal portion of the dorsal raphe nucleus has an anxiolytic effect on rats in the elevated T-mazeQ48006915
Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects.Q48068641
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Anxiogenic-like action of galanin after intra-amygdala administration in the rat.Q48116165
Galanin modulating effect on restraint stress-induced short- and long-term behavioral changes in Wistar rats.Q48123437
Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats.Q48128534
Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeysQ48174465
Plasma galanin is a biomarker for severity of major depressive disorder.Q48179516
Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory painQ48257159
Kisspeptin regulation of arcuate neuron excitability in kisspeptin receptor knockout miceQ48288686
Galanin: a significant role in depression?Q48294893
Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous systemQ48307913
Sexually dimorphic immunoreactivity of galanin and colocalization with arginine vasotocin in the chicken brain (Gallus gallus domesticus).Q48394011
Immunocytochemical localization of a galanin-like peptidergic system in the brain of two urodele and two anuran species (Amphibia).Q48451310
Decreased Circulating Levels of Spexin in Obese ChildrenQ37057932
Kisspeptin in the medial amygdala and sexual behavior in male ratsQ37094337
An overview of animal models of pain: disease models and outcome measuresQ37282107
Increased intake of ethanol and dietary fat in galanin overexpressing miceQ37486392
Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide.Q37550046
Inhibitory effect of kisspeptins on insulin secretion from isolated mouse isletsQ37611960
Brain galanin system genes interact with life stresses in depression-related phenotypesQ37725359
Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathyQ37738001
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Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety.Q37875034
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Changes in Hypothalamic Expression Levels of Galanin-Like Peptide in Rat and Mouse Models Support That It Is a Leptin-Target PeptideQ38354664
Anxiety in Patients with Schizophrenia: Epidemiology and ManagementQ38611406
Kisspeptin-10 inhibits proliferation and regulates lipolysis and lipogenesis processes in 3T3-L1 cells and isolated rat adipocytes.Q38716576
Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescentsQ38719956
Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-α But Not Estrogen Receptor-βQ38827551
Effects of kisspeptin on parameters of the HPA axisQ39579159
Molecular cloning and functional characterization of spexin in orange-spotted grouper (Epinephelus coioides).Q39947188
Effects of high-fat diet-induced obesity and diabetes on Kiss1 and GPR54 expression in the hypothalamic-pituitary-gonadal (HPG) axis and peripheral organs (fat, pancreas and liver) in male rats.Q40016317
Galanin microinjection into the dorsal periaqueductal gray matter produces paradigm-dependent anxiolytic effectsQ40123192
A role for kisspeptin in islet functionQ40257928
Messenger plasticity in primary sensory neurons following axotomy and its functional implicationsQ40387628
Pharmacological and functional characterization of galanin-like peptide fragments as potent galanin receptor agonistsQ40412243
[125I]-Galanin binding in brain of wildtype, and galanin- and GalR1-knockout mice: strain and species differences in GalR1 density and distributionQ40446216
Peptides and the blood-brain barrier: the status of our understandingQ40577778
Ya-fish (Schizothorax prenanti) spexin: identification, tissue distribution and mRNA expression responses to periprandial and fastingQ40603455
Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic AxisQ40812905
Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesityQ41664547
Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-683, an investigational metastin analogue in healthy men.Q41835682
AgRP to Kiss1 neuron signaling links nutritional state and fertilityQ42318122
Goldfish spexin: solution structure and novel function as a satiety factor in feeding control.Q42439141
Galanin-like immunoreactivity within the primate basal forebrain: differential staining patterns between humans and monkeysQ42465412
Study on the effect of peripheral kisspeptin administration on basal and glucose-induced insulin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta).Q42480848
Galanin receptor 3--a potential target for acute pancreatitis therapy.Q42483685
Distribution of galanin-like immunoreactivity in the human brainQ42490902
Microinjection of galanin into the medial preoptic nucleus facilitates copulatory behavior in the male rat.Q42673473
Effects of kisspeptin-13 on the hypothalamic-pituitary-adrenal axis, thermoregulation, anxiety and locomotor activity in ratsQ42679935
Centrally injected kisspeptin reduces food intake by increasing meal intervals in miceQ42703132
Escitalopram affects spexin expression in the rat hypothalamus, hippocampus and striatumQ48486228
Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutritionQ48486408
Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male ratsQ48491856
Obesity on a high-fat diet: role of hypothalamic galanin in neurons of the anterior paraventricular nucleus projecting to the median eminence.Q48493273
Antinociceptive effects of galanin in the nucleus accumbens of ratsQ48507087
Distribution of kisspeptin neurones in the adult female mouse brainQ48577946
Galanin-like peptide stimulates food intake in the rat.Q48628623
Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum.Q48851655
What are neuropeptides?Q48895350
Stimulation of feeding by galanin: Anatomical localization and behavioral specificity of this peptide's effects in the brainQ48913557
Galanin-like peptide (GALP) is expressed in rat hypothalamus and pituitary, but not in DRG.Q49153311
Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male miceQ49196823
Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic ratsQ49731249
Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neuronsQ50082095
Relationship of circulating spexin with markers of cardiovascular disease: a pilot study in adolescents with obesityQ50088377
Effect of Oxyntomodulin, Glucagon, GLP-1, and Combined Glucagon +GLP-1 Infusion on Food Intake, Appetite, and Resting Energy Expenditure.Q51295926
Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes.Q51299485
Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty.Q51494490
Galanin in the hypothalamus of fed and fasted lean and obese Zucker ratsQ51599023
Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat.Q51683976
Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala.Q51737576
Functional circuit architecture underlying parental behaviour.Q52593079
Progesterone modulates pro-inflammatory cytokine expression profile after spinal cord injury: Implications for neuropathic pain.Q53158844
Circulating Spexin Levels Negatively Correlate With Age, BMI, Fasting Glucose, and Triglycerides in Healthy Adult Women.Q55284075
Intrinsic links among sex, emotion, and reproduction.Q55388869
Inactivating KISS1 mutation and hypogonadotropic hypogonadismQ55671569
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptorQ57118375
Kisspeptin and the control of emotions, mood and reproductive behaviourQ57298973
On the effects of human galanin in manQ58169440
Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functionsQ58599420
Inhibition of GALR1 in PFC Alleviates Depressive-Like Behaviors in Postpartum Depression Rat Model by Upregulating CREB-BNDF and 5-HT LevelsQ59328950
Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the ratQ60050258
Gangliocytes in Neuroblastic Tumors Express Alarin, a Novel Peptide Derived by Differential Splicing of the Galanin-Like Peptide GeneQ60162973
Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite ControlQ60948729
Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNSQ64063714
Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body WeightQ64102423
Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice.Q64882784
Galanin inhibits sexual behavior in male ratsQ67541044
Galanin of the homologous species inhibits insulin secretion in the rat and in the pigQ67676195
Presence of galanin in human pancreatic nerves and inhibition of insulin secretion from isolated human isletsQ67698313
Galanin: effects on basal and stimulated insulin and glucagon secretion in the mouseQ68993054
Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious ratsQ68999116
Effects of neuropeptide Y, NPY analog (norleucine4-NPY), galanin and neuropeptide K on LH release in ovariectomized (ovx) and ovx estrogen, progesterone-treated ratsQ69017159
High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humansQ69094555
Galanin microinjected into the medial preoptic nucleus facilitates female- and male-typical sexual behaviors in the female ratQ71340391
Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the ratQ71606534
P577publication date2020-12-03
P1433published inNature Reviews EndocrinologyQ2079257
P1476titleFunctions of galanin, spexin and kisspeptin in metabolism, mood and behaviour