tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9708296)

tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis is …
instance of (P31):
biological pathwayQ4915012
tRNA catabolic processQ21120472

External links are
P2888exact matchhttps://identifiers.org/reactome:R-HSA-9708296
P3937Reactome IDR-HSA-9708296

P2860cites workCharacterization of ribonucleolytic activity of angiogenin towards tRNAQ24339495
tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene ExpressionQ26771993
Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamilyQ28190531
Stress induces tRNA cleavage by angiogenin in mammalian cellsQ28305246
Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets.Q30409998
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs).Q30436133
Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAsQ33511934
Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assemblyQ33796328
Angiogenin-induced tRNA fragments inhibit translation initiationQ34209434
tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma.Q36567903
Angiogenin cleaves tRNA and promotes stress-induced translational repressionQ37237900
Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybridQ37406083
Rapid RNase L-Driven Arrest of Protein Synthesis in the dsRNA Response without Degradation of Translation Machinery.Q38624988
Biogenesis and Function of Transfer RNA-Related Fragments (tRFs).Q38855205
The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA PathwayQ40681550
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.Q52643909
tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent mannerQ56336234
DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAsQ58105960
tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease DevelopmentQ60915603
Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3-mediated gene silencingQ90466778
Role of tRNA-derived fragments in cancer: novel diagnostic and therapeutic targets tRFs in cancerQ90482867
Action mechanisms and research methods of tRNA-derived small RNAsQ96817077
Processing by RNase 1 forms tRNA halves and distinct Y RNA fragments in the extracellular environmentQ96837010
Noncanonical Roles of tRNAs: tRNA Fragments and BeyondQ98719506
tRNA-Derived Small RNAs: Novel Epigenetic RegulatorsQ100383011
P703found in taxonHomo sapiensQ15978631
P527has part(s)ANG cleaves tRNA to yield tRNA halvesQ106514568
DICER1 cleaves tRNAQ106514569
DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybridQ106514570
ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)Q106514571
P361part ofGene Silencing by RNAQ45316872

Reverse relations

part of (P361)
Q106514568ANG cleaves tRNA to yield tRNA halves
Q106514569DICER1 cleaves tRNA
Q106514570DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid
Q106514571ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)

Q45316872Gene Silencing by RNAhas part(s)P527

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