The SARS-CoV-2 Entry Inhibition Mechanisms of Serine Protease Inhibitors, OM-85, Heparin and Soluble HS Might Be Linked to HS Attachment Sites

scientific article

The SARS-CoV-2 Entry Inhibition Mechanisms of Serine Protease Inhibitors, OM-85, Heparin and Soluble HS Might Be Linked to HS Attachment Sites is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/MOLECULES27061947
P932PMC publication ID8954261
P698PubMed publication ID35335311

P2093author name stringAntony Cheudjeu
P2860cites workTMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinQ24339582
Novel peptide inhibitors of angiotensin-converting enzyme 2.Q31133376
A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cellsQ33581409
Isolation and characterization of glycosaminoglycans in human plasmaQ34566026
Glycosaminoglycans in the human cornea: age-related changesQ35027316
Control of chondrogenesis in limb-bud cell cultures by bromodeoxyuridineQ35109400
Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cellsQ35129308
The glycosaminoglycans of normal and arthritic cartilageQ35572274
Coconut-derived D-xylose affects postprandial glucose and insulin responses in healthy individualsQ35675502
The glycosaminoglycans of the human artery and their changes in atherosclerosisQ35903544
Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations.Q36059429
D-Xylose as a sugar complement regulates blood glucose levels by suppressing phosphoenolpyruvate carboxylase (PEPCK) in streptozotocin-nicotinamide-induced diabetic rats and by enhancing glucose uptake in vitroQ36547028
Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover designQ36686857
Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes.Q36942072
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.Q37045970
Serine proteasesQ37175533
Anti-inflammatory activity of chondroitin sulfateQ37230656
The binding of heparin to the extracellular matrix of endothelial cells up-regulates the synthesis of an antithrombotic heparan sulfate proteoglycan.Q39973601
Chemical modifications of algal mannans and xylomannans: effects on antiviral activity.Q40306393
Involvement of glycosaminoglycans in the attachment of pneumococci to nasopharyngeal epithelial cells.Q40359764
Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparinQ42125176
Expression of externally-disposed heparin/heparan sulfate binding sites by uterine epithelial cellsQ42478823
Effects of cycloheximide, brefeldin A, suramin, heparin and primaquine on proteoglycan and glycosaminoglycan biosynthesis in human embryonic skin fibroblastsQ46447622
On the weight of the skin.Q47450230
Normal organ weights in men: part II-the brain, lungs, liver, spleen, and kidneysQ48766796
A Discussion on the Regulation of Blood Flow and PressureQ50234963
Streptococcus pneumoniae sheds syndecan-1 ectodomains through ZmpC, a metalloproteinase virulence factor.Q53584956
Effect of insulin and growth hormone on the synthesis of radiolabelled proteoglycans from cultured human arterial smooth-muscle cells.Q54119763
Heparan Sulfate Proteoglycans in InfectionQ57773159
Comparative effects of glucose and xylose on blood pressure, gastric emptying and incretin hormones in healthy older subjectsQ62479038
Regulation of chondroitin sulfate synthesis. Effect of beta-xylosides on synthesis of chondroitin sulfate proteoglycan, chondroitin sulfate chains, and core proteinQ67012919
Synthesis and secretion of an altered chondroitin sulfate proteoglycanQ67017960
Glycosylphosphatidylinositol-anchored and core protein-intercalated heparan sulfate proteoglycans in rat ovarian granulosa cells have distinct secretory, endocytotic, and intracellular degradative pathwaysQ68055528
Heparin stimulates the synthesis and modifies the sulfation pattern of heparan sulfate proteoglycan from endothelial cellsQ69652468
The distribution of the glycosaminoglycans in the anatomic components of the lung and the changes in concentration of these macromolecules during development and agingQ70394263
Decrease in the glycosaminoglycan content in the skin of diabetic rats. The role of IGF-I, IGF-binding proteins and proteolytic activityQ71284372
Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide compositionQ73098910
Anti-inflammatory activity of chondroitin sulfateQ77320493
Human venous and arterial glycosaminoglycans have similar affinity for plasma low-density lipoproteinsQ78067811
The action of insulin on the transport of glucose through the cell membraneQ78634586
Effect of insulin on D-xylose disappearance in diabetic patientsQ78836026
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease InhibitorQ88292103
Xylosyltransferase 1 and the GAG Attachment SiteQ89011214
ADAM17 inhibition may exert a protective effect on COVID-19Q91934668
Bacterial Lysates as Immunotherapies for Respiratory Infections: Methods of PreparationQ96687264
Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactionsQ97550549
Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19Q98730787
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2Q99707959
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin DerivativesQ101563850
Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2Q102075238
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage siteQ104739115
COVID-19 Vaccine Rollout: will it affect the Rates of Vaccine Hesitancy in Africa?Q105254138
Contribution of Syndecans to the Cellular Entry of SARS-CoV-2Q107098692
Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptorsQ107202129
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activityQ107272363
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cellsQ107338266
Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung CancerQ107376911
Cell entry by SARS-CoV-2Q107392240
Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV-2Q107466974
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infectionQ108396534
ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated HeparinQ110245632
Syndecan-4 Is a Key Facilitator of the SARS-CoV-2 Delta Variant's Superior TransmissionQ110734076
SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain SignalingQ110734107
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2Q110951933
Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetesQ111459829
Elastase and exacerbation of neutrophil innate immunity are involved in multi-visceral manifestations of COVID-19Q111459830
Access to Highly Purified Chondroitin Sulfate for Appropriate Treatment of Osteoarthritis: A ReviewQ111459831
In Vitro Analysis of the Anti-viral Potential of nasal spray constituents against SARS-CoV-2Q111459832
Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2Q111459833
Study of Volume, Weight and Size of Normal Pancreas, Spleen and Kidney in Adults AutopsiesQ111459834
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID‐19Q111459835
Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical TrialQ111459836
UDP-D-Xylose : Proteoglycan Core Protein β-D-Xylosyltransferase: A New Marker of Cartilage Destruction in Chronic Joint DiseasesQ111459860
OM-85 Broncho-Vaxom, a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial CellsQ111459863
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19Q111459864
Effectiveness of Covid-19 Vaccines over a 9-Month Period in North CarolinaQ111459865
SARS-CoV-2: ACE inhibitors, disastrous or desirable?Q111459866
STUDIES OF TISSUE PERMEABILITYQ111459867
Access to and equitable distribution of COVID-19 vaccine in low-income countriesQ111459868
Inflammatory arthritis in patients with COVID-19Q111459870
Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery processQ111459871
Antiviral strategies should focus on stimulating the biosynthesis of heparan sulfates, not their inhibitionQ111459872
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpharmaceutical scienceQ7180763
camostat mesylateQ23731028
nafamostat mesylateQ27252259
D-xyloseQ75082498
SARS-CoV-2Q82069695
spike glycoprotein [SARS-CoV-2]Q87917585
P304page(s)1947
P577publication date2022-03-17
P1433published inMoleculesQ151332
P1476titleThe SARS-CoV-2 Entry Inhibition Mechanisms of Serine Protease Inhibitors, OM-85, Heparin and Soluble HS Might Be Linked to HS Attachment Sites
P478volume27

Search more.