KEAP1-NFE2L2 pathway

instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9755511)

Wikidata entity: Q113000192



P2860 cites work ... Q49945078 (???) ???
P2860 cites work ... Q52673272 (???) ???
P2860 cites work ... Q90893987 (???) ???
P2860 cites work ... Q91873045 (???) ???
P2860 cites work ... Q96685720 (???) ???
P2860 cites work ... Q97521418 (???) ???
P2860 cites work ... Q97567946 (???) ???
P2888 exact match Url Reactome | KEAP1-NFE2L2 pathway ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q50290157 (PRDX1 overoxidizes) PRDX1 overoxidizes
P527 has part(s) ... Q106513210 (NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1) NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
P527 has part(s) ... Q106513212 (26S proteasome degrades Ub-NFE2L2) 26S proteasome degrades Ub-NFE2L2
P527 has part(s) ... Q106513214 (CK2 phosphorylates NFE2L2) CK2 phosphorylates NFE2L2
P527 has part(s) ... Q106513215 (PKC phosphorylates NFE2L2) PKC phosphorylates NFE2L2
P527 has part(s) ... Q106513216 (NFE2L2 translocates from cytosol to nucleoplasm) NFE2L2 translocates from cytosol to nucleoplasm
P527 has part(s) ... Q106513217 (NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2) NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
P527 has part(s) ... Q106519822 (Regulation of BACH1 activity) Regulation of BACH1 activity
P527 has part(s) ... Q112978003 (MAP1LC3B binds KEAP1 and SQSTM1) MAP1LC3B binds KEAP1 and SQSTM1
P527 has part(s) ... Q112978004 (SESN1,SESN1 bind SQSTM1 and KEAP1) SESN1,SESN1 bind SQSTM1 and KEAP1
P527 has part(s) ... Q112978005 (SRXN1 reduces hyperoxidized PRDX1 dimer) SRXN1 reduces hyperoxidized PRDX1 dimer
P527 has part(s) ... Q112978059 (KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer) KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
P527 has part(s) ... Q112978060 (SQSTM1 oligomer is phosphorylated) SQSTM1 oligomer is phosphorylated
P527 has part(s) ... Q112978061 (p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1) p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
P527 has part(s) ... Q112978062 (RBX1:CUL3 dissociates from forming autophagosome) RBX1:CUL3 dissociates from forming autophagosome
P527 has part(s) ... Q112978063 (UBXN7 binds VCP hexamer:UBF1:NPLOC4) UBXN7 binds VCP hexamer:UBF1:NPLOC4
P527 has part(s) ... Q112978065 (Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation) Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
P527 has part(s) ... Q112978066 (CUL3:RBX1 ubiquitinates KEAP1) CUL3:RBX1 ubiquitinates KEAP1
P527 has part(s) ... Q112978067 (SQSTM1 oligomerizes) SQSTM1 oligomerizes
P527 has part(s) ... Q112978068 (KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2) KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
P527 has part(s) ... Q112978069 (TRIM21 ubiquitinates SQSTM1) TRIM21 ubiquitinates SQSTM1
P527 has part(s) ... Q112978073 (UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex) UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
P527 has part(s) ... Q112978074 (HBV X protein binds SQSTM1 oligomer) HBV X protein binds SQSTM1 oligomer
P527 has part(s) ... Q112978076 (MUL1 ubiquitinates UBXN7) MUL1 ubiquitinates UBXN7
P527 has part(s) ... Q112978078 (ub UBXN7 is degraded by the 26S proteasome) ub UBXN7 is degraded by the 26S proteasome
P527 has part(s) ... Q113000191 (Nuclear events mediated by NFE2L2) Nuclear events mediated by NFE2L2
P31 instance of ... Q4915012 (biological pathway) biological pathway
P361 part of ... Q106519828 (Cellular response to chemical stress) Cellular response to chemical stress

External Ids
P3937Reactome IDR-HSA-9755511

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