Johan H. van Es

researcher

Johan H. van Es is …
instance of (P31):
humanQ5

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P496ORCID iD0000-0002-1338-7078
P2038ResearchGate profile IDJohan-Es

P106occupationresearcherQ1650915

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author (P50)
Q47308901A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche
Q42152874A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal
Q24338902A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta
Q46832278A20 controls intestinal homeostasis through cell-specific activities
Q50593562An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.
Q36155098An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking
Q35762264Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
Q89831611Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells
Q95933360Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
Q38710117Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
Q45847463Canonical Wnt signaling negatively modulates regulatory T cell function.
Q34237942Controlled gene expression in primary Lgr5 organoid cultures
Q39751765Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition
Q28304418Crypt stem cells as the cells-of-origin of intestinal cancer
Q33742017DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus
Q31110759De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
Q47961996De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
Q28506643Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand
Q28300176Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
Q34637873Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
Q37211856Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
Q36675173Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.
Q92023561Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion
Q90427601Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
Q57066409Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
Q38914917Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations
Q37369513Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research
Q28593397HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
Q91321638Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping
Q28131701Identification of stem cells in small intestine and colon by marker gene Lgr5
Q36791239In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Q34522818Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition
Q29619410Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
Q42739535Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.
Q53447869Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Q34301244Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Q63406949Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Q34291885Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
Q89998661Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
Q63406947Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Q36528951Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
Q34332458Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele
Q40071670Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
Q37633867Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
Q88721108Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche
Q91750889Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
Q91824416Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
Q91202976Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling
Q34425223Paneth cells
Q29616197Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Q35764241Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia
Q92304607Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids
Q60911613Profiling proliferative cells and their progeny in damaged murine hearts
Q50614489Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Q50788436Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
Q37264185Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
Q38797646Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
Q35018668Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium
Q42915923Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus
Q28586813SOX9 is required for the differentiation of paneth cells in the intestinal epithelium
Q28239639Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Q35799683Single-molecule transcript counting of stem-cell markers in the mouse intestine
Q36029963T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine
Q34122210TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling
Q41698268Targeting development of incretin-producing cells increases insulin secretion
Q21135289The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis
Q34280882The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
Q28507783Transcription factor achaete scute-like 2 controls intestinal stem cell fate
Q47661472Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Q24296595Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
Q28298678Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Q28593773Wnt signalling induces maturation of Paneth cells in intestinal crypts
Q35062431You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

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