Abstract is: Oral rehydration therapy (ORT) is a type of fluid replacement used to prevent and treat dehydration, especially due to diarrhea. It involves drinking water with modest amounts of sugar and salts, specifically sodium and potassium. Oral rehydration therapy can also be given by a nasogastric tube. Therapy should routinely include the use of zinc supplements. Use of oral rehydration therapy has been estimated to decrease the risk of death from diarrhea by up to 93%. Side effects may include vomiting, high blood sodium, or high blood potassium. If vomiting occurs, it is recommended that use be paused for 10 minutes and then gradually restarted. The recommended formulation includes sodium chloride, sodium citrate, potassium chloride, and glucose. Glucose may be replaced by sucrose and sodium citrate may be replaced by sodium bicarbonate, if not available. It works as glucose increases the uptake of sodium and thus water by the intestines. A number of other formulations are also available including versions that can be made at home. However, the use of homemade solutions has not been well studied. Oral therapy was developed in the 1940s using electrolyte solutions with or without glucose on an empirical basis chiefly for mild or convalescent patients, but did not come into common use for rehydration and maintenance therapy until after the discovery that glucose promoted sodium and water absorption during cholera in the 1960s. It is on the World Health Organization's List of Essential Medicines. Globally, as of 2015, oral rehydration therapy is used by 41% of children with diarrhea. This use has played an important role in reducing the number of deaths in children under the age of five.
| medical treatment | Q179661 |
| fluid replacement | Q4529664 |
| management of dehydration | Q17156403 |
| hydration | Q25394518 |
| P673 | eMedicine ID | 906999-treatment |
| P1417 | Encyclopædia Britannica Online ID | topic/oral-rehydration-salts |
| P646 | Freebase ID | /m/05b8j1 |
| P3827 | JSTOR topic ID (archived) | oral-rehydration |
| P6366 | Microsoft Academic ID | 2777717012 |
| P10283 | OpenAlex ID | C2777717012 |
| P2892 | UMLS CUI | C0029168 |
| C0086904 | ||
| P11143 | WikiProjectMed ID | Oral rehydration therapy |
| P2283 | uses | oral rehydration solution | Q29898848 |
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| Q53873469 | Zinc therapy for diarrhoea increased the use of oral rehydration therapy and reduced the use of antibiotics in Bangladeshi children. |
| Q39671628 | Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial |
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| Q68523778 | [Evaluation of the efficacy of oral rehydration therapy in food toxinfections] |
| Q70894295 | [Experience with the implementation of oral rehydration therapy of the State Secretariat of Health of Sergipe] |
| Q74791337 | [Maternal practices in infantile diarrheic disease and oral rehydration therapy] |
| Q91573359 | [Oral Rehydration Therapy in Thoracic Surgery] |
| Q84619019 | [Oral rehydration therapy before surgery in elderly patients] |
| Q72023391 | [Oral rehydration therapy for acute diarrhea in a region of northeastern Brazil, 1986-1989] |
| Q70570995 | [Oral rehydration therapy in Europe] |
| Q70746938 | [Oral rehydration therapy in Europe] |
| Q69568241 | [Oral rehydration therapy in acute diarrheal syndrome. A critical analysis of various aspects] |
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| Q83517012 | [Oral rehydration therapy with OS-1 for advanced and recurrent gastrointestinal cancer patients] |
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| Q70700444 | [Oral rehydration therapy] |
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| Q67955072 | [Patterns in the household acceptance of oral rehydration therapy in a cohort of rural mothers] |
| Q84349480 | [Preoperative fluid and electrolyte management by oral rehydration therapy] |
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| Q51372686 | [Safety of preoperative oral rehydration therapy]. |
| Q51370150 | [Significance of preoperative oral rehydration therapy]. |
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| Q51296374 | [Use and Safety of Preoperative Oral Rehydration Therapy Using a Jelly Type Oral Rehydration Solution]. |
| Q40878 | diarrhea | drug or therapy used for treatment | P2176 |
| Q29898848 | oral rehydration solution | has use | P366 |
| Q37155 | World Health Organization Model List of Essential Medicines | has part(s) | P527 |
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