Abstract is: The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6. It is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.
| P594 | Ensembl gene ID | ENSG00000112164 |
| P704 | Ensembl transcript ID | ENST00000373256 |
| P351 | Entrez Gene ID | 2740 |
| P2888 | exact match | http://identifiers.org/ncbigene/2740 |
| P646 | Freebase ID | /m/02pqwzw |
| P353 | HGNC gene symbol | GLP1R |
| P354 | HGNC ID | 4324 |
| P593 | HomoloGene ID | 1558 |
| P6366 | Microsoft Academic ID | 185280430 |
| P492 | OMIM ID | 138032 |
| 138032 | ||
| P10283 | OpenAlex ID | C185280430 |
| P639 | RefSeq RNA ID | NM_002062 |
| NR_136562 | ||
| NR_136563 | ||
| P2892 | UMLS CUI | C1415105 |
| P1057 | chromosome | human chromosome 6 | Q540857 |
| P4196 | cytogenetic location | 6p21.2 | |
| P688 | encodes | Glucagon like peptide 1 receptor | Q5572289 |
| P5572 | expressed in | medulla oblongata | Q189033 |
| pons | Q192570 | ||
| vena cava | Q372409 | ||
| periodontal fiber | Q540092 | ||
| sperm | Q17145 | ||
| cardia | Q1542842 | ||
| oocyte | Q3246226 | ||
| body of pancreas | Q4936946 | ||
| islet of Langerhans | Q728309 | ||
| secondary oocyte | Q66509944 | ||
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P645 | genomic end | 39055519 | |
| 39091303 | |||
| P644 | genomic start | 39016574 | |
| 39048781 | |||
| P684 | ortholog | Glp1r | Q14909916 |
| Glp1r | Q24370076 | ||
| P2548 | strand orientation | forward strand | Q22809680 |
FileName: PBB GE GLP1R 208390 s at fs.png
Description: Gene expression pattern of the GLP1R gene.
Artist: AndrewGNF at English Wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE GLP1R 208391 s at fs.png
Description: Gene expression pattern of the GLP1R gene.
Artist: AndrewGNF at English Wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE GLP1R 208401 s at fs.png
Description: Gene expression pattern of the GLP1R gene.
Artist: AndrewGNF at English Wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
| Q27595097 | hsa-miR-204-5p |
| Q27593520 | hsa-miR-211-5p |
| Q27593265 | hsa-miR-3657 |
| Q27594445 | hsa-miR-3667-3p |
| Q27595175 | hsa-miR-4292 |
| Q27593369 | hsa-miR-4308 |
| Q27594165 | hsa-miR-4433b-5p |
| Q27594777 | hsa-miR-4646-3p |
| Q27595160 | hsa-miR-4669 |
| Q27594297 | hsa-miR-4755-5p |
| Q27594183 | hsa-miR-4780 |
| Q27593301 | hsa-miR-5006-3p |
| Q27594021 | hsa-miR-5088-3p |
| Q27594599 | hsa-miR-574-5p |
| Q27593339 | hsa-miR-623 |
| Q27592776 | hsa-miR-6734-3p |
| Q27594807 | hsa-miR-6780b-3p |
| Q27593936 | hsa-miR-6791-5p |
| Q27593772 | hsa-miR-6867-5p |
| Q27593840 | hsa-miR-6868-3p |
| Q30230828 | GPCRs, Class B Secretin-like | has part(s) | P527 |
| Q5572289 | Glucagon like peptide 1 receptor | encoded by | P702 |
| cy | GLP1R | wikipedia |
| Glucagon-like peptide-1 receptor | wikipedia | |
| Persian (fa / Q9168) | گیرنده پپتید شبهگلوکاگون ۱ | wikipedia |
| Récepteur du glucagon-like peptide-1 | wikipedia | |
| Serbo-Croatian (sh / Q9301) | Receptor glukagonu sličnog peptida 1 | wikipedia |
| Receptor glukagonu sličnog peptida 1 | wikipedia | |
| Tatar language (tt / Q25285) | GLP1R | wikipedia |
| GLP1R | wikipedia |
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