Toll-like receptor 4

mammalian protein found in Mus musculus

Wikidata entity: Q14914104



P682 biological process ... Q184726 (phagocytosis) phagocytosis
P682 biological process ... Q828130 (signal transduction) signal transduction
P682 biological process ... Q428253 (innate immune response) innate immune response
P682 biological process ... Q14330834 (response to lipopolysaccharide) response to lipopolysaccharide
P682 biological process ... Q14331037 (positive regulation of peptidyl-tyrosine phosphorylation) positive regulation of peptidyl-tyrosine phosphorylation
P682 biological process ... Q14914100 (innate immune response-activating signal transduction) innate immune response-activating signal transduction
P682 biological process ... Q14916317 (immune system process) immune system process
P682 biological process ... Q14599315 (response to oxidative stress) response to oxidative stress
P682 biological process ... Q14633893 (positive regulation of gene expression) positive regulation of gene expression
P682 biological process ... Q14758937 (positive regulation of nitric oxide biosynthetic process) positive regulation of nitric oxide biosynthetic process
P682 biological process ... Q14761969 (positive regulation of NF-kappaB transcription factor activity) positive regulation of NF-kappaB transcription factor activity
P682 biological process ... Q14818063 (positive regulation of apoptotic process) positive regulation of apoptotic process
P682 biological process ... Q14818068 (positive regulation of transcription by RNA polymerase II) positive regulation of transcription by RNA polymerase II
P682 biological process ... Q14819790 (negative regulation of tumor necrosis factor production) negative regulation of tumor necrosis factor production
P682 biological process ... Q14819849 (inflammatory response) inflammatory response
P682 biological process ... Q21097313 (positive regulation of reactive oxygen species biosynthetic process) positive regulation of reactive oxygen species biosynthetic process
P682 biological process ... Q21103398 (positive regulation of cytokine production involved in inflammatory response) positive regulation of cytokine production involved in inflammatory response
P682 biological process ... Q21114592 (positive regulation of NLRP3 inflammasome complex assembly) positive regulation of NLRP3 inflammasome complex assembly
P682 biological process ... Q21173242 (regulation of dendritic cell cytokine production) regulation of dendritic cell cytokine production
P682 biological process ... Q22273352 (cellular response to amyloid-beta) cellular response to amyloid-beta
P682 biological process ... Q22304816 (positive regulation of cellular response to macrophage colony-stimulating factor stimulus) positive regulation of cellular response to macrophage colony-stimulating factor stimulus
P682 biological process ... Q22304824 (positive regulation of oxidative stress-induced neuron death) positive regulation of oxidative stress-induced neuron death
P682 biological process ... Q34301794 (cellular response to oxidised low-density lipoprotein particle stimulus) cellular response to oxidised low-density lipoprotein particle stimulus
P682 biological process ... Q54810623 (negative regulation of cold-induced thermogenesis) negative regulation of cold-induced thermogenesis
P682 biological process ... Q14819884 (response to ethanol) response to ethanol
P682 biological process ... Q14820900 (regulation of sensory perception of pain) regulation of sensory perception of pain
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14859605 (activation of NF-kappaB-inducing kinase activity) activation of NF-kappaB-inducing kinase activity
P682 biological process ... Q14859639 (positive regulation of inflammatory response) positive regulation of inflammatory response
P682 biological process ... Q14859645 (cellular response to mechanical stimulus) cellular response to mechanical stimulus
P682 biological process ... Q14860511 (positive regulation of interleukin-8 production) positive regulation of interleukin-8 production
P682 biological process ... Q14860518 (regulation of inflammatory response) regulation of inflammatory response
P682 biological process ... Q14860519 (detection of temperature stimulus involved in sensory perception of pain) detection of temperature stimulus involved in sensory perception of pain
P682 biological process ... Q14860864 (microglial cell activation) microglial cell activation
P682 biological process ... Q14863111 (cellular response to lipopolysaccharide) cellular response to lipopolysaccharide
P682 biological process ... Q14863401 (positive regulation of B cell proliferation) positive regulation of B cell proliferation
P682 biological process ... Q14863696 (positive regulation of DNA binding) positive regulation of DNA binding
P682 biological process ... Q14863711 (negative regulation of ERK1 and ERK2 cascade) negative regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14864035 (positive regulation of I-kappaB kinase/NF-kappaB signaling) positive regulation of I-kappaB kinase/NF-kappaB signaling
P682 biological process ... Q14864136 (positive regulation of stress-activated MAPK cascade) positive regulation of stress-activated MAPK cascade
P682 biological process ... Q14864447 (negative regulation of interferon-gamma production) negative regulation of interferon-gamma production
P682 biological process ... Q14864450 (negative regulation of interleukin-6 production) negative regulation of interleukin-6 production
P682 biological process ... Q14864458 (positive regulation of MHC class II biosynthetic process) positive regulation of MHC class II biosynthetic process
P682 biological process ... Q14864461 (positive regulation of DNA-binding transcription factor activity) positive regulation of DNA-binding transcription factor activity
P682 biological process ... Q14864505 (positive regulation of interferon-gamma production) positive regulation of interferon-gamma production
P682 biological process ... Q14864542 (toll-like receptor signaling pathway) toll-like receptor signaling pathway
P682 biological process ... Q14864543 (MyD88-dependent toll-like receptor signaling pathway) MyD88-dependent toll-like receptor signaling pathway
P682 biological process ... Q14864550 (positive regulation of interleukin-12 production) positive regulation of interleukin-12 production
P682 biological process ... Q14864551 (positive regulation of interleukin-6 production) positive regulation of interleukin-6 production
P682 biological process ... Q14864552 (positive regulation of tumor necrosis factor production) positive regulation of tumor necrosis factor production
P682 biological process ... Q14864554 (toll-like receptor 4 signaling pathway) toll-like receptor 4 signaling pathway
P682 biological process ... Q14864567 (positive regulation of macrophage cytokine production) positive regulation of macrophage cytokine production
P682 biological process ... Q14864569 (cellular response to lipoteichoic acid) cellular response to lipoteichoic acid
P682 biological process ... Q14864861 (astrocyte development) astrocyte development
P682 biological process ... Q14864910 (activation of innate immune response) activation of innate immune response
P682 biological process ... Q14864950 (positive regulation of JNK cascade) positive regulation of JNK cascade
P682 biological process ... Q14864986 (positive regulation of interferon-alpha production) positive regulation of interferon-alpha production
P682 biological process ... Q14864987 (positive regulation of interleukin-10 production) positive regulation of interleukin-10 production
P682 biological process ... Q14864990 (positive regulation of macrophage activation) positive regulation of macrophage activation
P682 biological process ... Q14865219 (positive regulation of chemokine production) positive regulation of chemokine production
P682 biological process ... Q14865229 (defense response to Gram-negative bacterium) defense response to Gram-negative bacterium
P682 biological process ... Q14865489 (macrophage activation) macrophage activation
P682 biological process ... Q14866208 (I-kappaB phosphorylation) I-kappaB phosphorylation
P682 biological process ... Q14866212 (positive regulation of interferon-beta production) positive regulation of interferon-beta production
P682 biological process ... Q14866218 (TRIF-dependent toll-like receptor signaling pathway) TRIF-dependent toll-like receptor signaling pathway
P682 biological process ... Q14876566 (positive regulation of nitric-oxide synthase biosynthetic process) positive regulation of nitric-oxide synthase biosynthetic process
P682 biological process ... Q14881070 (positive regulation of platelet activation) positive regulation of platelet activation
P682 biological process ... Q14881238 (negative regulation of interleukin-17 production) negative regulation of interleukin-17 production
P682 biological process ... Q14885612 (response to bacterium) response to bacterium
P682 biological process ... Q14885627 (lipopolysaccharide-mediated signaling pathway) lipopolysaccharide-mediated signaling pathway
P682 biological process ... Q14885640 (cellular response to interferon-gamma) cellular response to interferon-gamma
P682 biological process ... Q14889541 (leukotriene metabolic process) leukotriene metabolic process
P682 biological process ... Q14897688 (detection of mechanical stimulus involved in sensory perception of pain) detection of mechanical stimulus involved in sensory perception of pain
P682 biological process ... Q14905686 (positive regulation of NIK/NF-kappaB signaling) positive regulation of NIK/NF-kappaB signaling
P682 biological process ... Q14905920 (positive regulation of lymphocyte proliferation) positive regulation of lymphocyte proliferation
P682 biological process ... Q14907443 (response to fatty acid) response to fatty acid
P682 biological process ... Q14908212 (mast cell activation) mast cell activation
P682 biological process ... Q14914088 (B cell proliferation involved in immune response) B cell proliferation involved in immune response
P682 biological process ... Q14914089 (nitric oxide production involved in inflammatory response) nitric oxide production involved in inflammatory response
P682 biological process ... Q14914091 (detection of lipopolysaccharide) detection of lipopolysaccharide
P682 biological process ... Q14914092 (negative regulation of interleukin-23 production) negative regulation of interleukin-23 production
P682 biological process ... Q14914093 (positive regulation of interleukin-1 production) positive regulation of interleukin-1 production
P682 biological process ... Q14914095 (intestinal epithelial structure maintenance) intestinal epithelial structure maintenance
P682 biological process ... Q14914096 (positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway) positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
P682 biological process ... Q14914097 (positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q189094 (cell surface) cell surface
P681 cell component ... Q824237 (endosome) endosome
P681 cell component ... Q424178 (membrane raft) membrane raft
P681 cell component ... Q3824358 (intracellular anatomical structure) intracellular anatomical structure
P681 cell component ... Q14327652 (integral component of membrane) integral component of membrane
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q14633850 (external side of plasma membrane) external side of plasma membrane
P681 cell component ... Q15325702 (phagocytic cup) phagocytic cup
P681 cell component ... Q21095104 (intrinsic component of plasma membrane) intrinsic component of plasma membrane
P681 cell component ... Q14859540 (integral component of plasma membrane) integral component of plasma membrane
P681 cell component ... Q14860538 (early endosome) early endosome
P681 cell component ... Q14864978 (lipopolysaccharide receptor complex) lipopolysaccharide receptor complex
P681 cell component ... Q14877465 (receptor complex) receptor complex
P702 encoded by ... Q14914099 (Tlr4) Tlr4
P2888 exact match Url UniProt ???
P2888 exact match Url UniProt ???
P2888 exact match Url None ???
P703 found in taxon ... Q83310 (house mouse) house mouse
P527 has part(s) ... Q24739837 (Leucine-rich repeat) Leucine-rich repeat
P527 has part(s) ... Q24780090 (Toll/interleukin-1 receptor homology (TIR) domain) Toll/interleukin-1 receptor homology (TIR) domain
P527 has part(s) ... Q24782645 (cysteine-rich flanking region, C-terminal) cysteine-rich flanking region, C-terminal
P527 has part(s) ... Q24783125 (leucine-rich repeat, typical subtype) leucine-rich repeat, typical subtype
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P680 molecular function ... Q14762999 (protein heterodimerization activity) protein heterodimerization activity
P680 molecular function ... Q14819233 (signaling receptor binding) signaling receptor binding
P680 molecular function ... Q14863345 (phosphatidylinositol 3-kinase binding) phosphatidylinositol 3-kinase binding
P680 molecular function ... Q14864356 (transmembrane signaling receptor activity) transmembrane signaling receptor activity
P680 molecular function ... Q14864979 (lipopolysaccharide binding) lipopolysaccharide binding
P680 molecular function ... Q14907423 (lipopolysaccharide immune receptor activity) lipopolysaccharide immune receptor activity
P361 part of ... Q423042 (membrane protein) membrane protein
P361 part of ... Q935326 (Leucine-rich repeat, protein family) Leucine-rich repeat, protein family
P361 part of ... Q24781235 (Leucine-rich repeat domain superfamily) Leucine-rich repeat domain superfamily
P361 part of ... Q41797047 (Toll/interleukin-1 receptor homology (TIR) domain superfamily) Toll/interleukin-1 receptor homology (TIR) domain superfamily
P361 part of ... Q83147204 (Toll/interleukin-1 receptor homology (TIR) domain, protein family) Toll/interleukin-1 receptor homology (TIR) domain, protein family
P361 part of ... Q83163261 (Cysteine-rich flanking region, C-terminal domain, protein family) Cysteine-rich flanking region, C-terminal domain, protein family
P361 part of ... Q95352444 (Leucine-rich repeat, typical subtype, protein family) Leucine-rich repeat, typical subtype, protein family
P129 physically interacts with ... Q423762 (paclitaxel) paclitaxel

External Ids
P705Ensembl protein IDENSMUSP00000045770
P705Ensembl protein IDENSMUSP00000102988
P638PDB structure ID5IJC
P638PDB structure ID3VQ1
P638PDB structure ID3VQ2
P638PDB structure ID5IJD
P638PDB structure ID2Z64
P638PDB structure ID5IJB
P637RefSeq protein IDNP_067272
P637RefSeq protein IDXP_036019857
P352UniProt protein IDQ9QUK6

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