Abstract is: Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3). Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.
| P594 | Ensembl gene ID | ENSG00000137265 |
| P704 | Ensembl transcript ID | ENST00000380956 |
| ENST00000468485 | ||
| ENST00000469834 | ||
| ENST00000493114 | ||
| ENST00000495137 | ||
| ENST00000696871 | ||
| ENST00000696872 | ||
| ENST00000696873 | ||
| P351 | Entrez Gene ID | 3662 |
| P2888 | exact match | http://identifiers.org/ncbigene/3662 |
| P646 | Freebase ID | /m/03gx1b1 |
| P353 | HGNC gene symbol | IRF4 |
| P354 | HGNC ID | 6119 |
| P593 | HomoloGene ID | 1842 |
| P6366 | Microsoft Academic ID | 12652872 |
| P492 | OMIM ID | 601900 |
| 601900 | ||
| P10283 | OpenAlex ID | C12652872 |
| P639 | RefSeq RNA ID | NM_001195286 |
| NM_002460 | ||
| NR_036585 | ||
| NR_046000 | ||
| XM_006715090 | ||
| XM_047418730 | ||
| P2892 | UMLS CUI | C0812314 |
| P1057 | chromosome | human chromosome 6 | Q540857 |
| P4196 | cytogenetic location | 6p25.3 | |
| P688 | encodes | Interferon regulatory factor 4 | Q21156369 |
| P5572 | expressed in | spleen | Q9371 |
| rectum | Q158716 | ||
| appendix | Q9656 | ||
| superficial temporal artery | Q494694 | ||
| lymph node | Q170758 | ||
| canal of the cervix | Q785307 | ||
| bone marrow cells | Q66004840 | ||
| cartilage tissue | Q66526729 | ||
| ectocervix | Q66592418 | ||
| epithelium of colon | Q66714209 | ||
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P2293 | genetic association | progressive supranuclear palsy | Q945930 |
| chronic lymphocytic leukemia | Q1088156 | ||
| skin carcinoma | Q18555943 | ||
| P645 | genomic end | 411447 | |
| 411443 | |||
| P644 | genomic start | 391739 | |
| P684 | ortholog | Irf4 | Q24391110 |
| irf4a | Q29782472 | ||
| Irf4 | Q18251683 | ||
| P2548 | strand orientation | forward strand | Q22809680 |
FileName: PBB GE IRF4 216986 s at fs.png
Description: Gene expression pattern of the IRF4 gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE IRF4 216987 at fs.png
Description: Gene expression pattern of the IRF4 gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
| Q27593972 | hsa-miR-1199-5p |
| Q27593603 | hsa-miR-1225-3p |
| Q27593522 | hsa-miR-1233-3p |
| Q27594036 | hsa-miR-125a-5p |
| Q27593173 | hsa-miR-125b-5p |
| Q27594508 | hsa-miR-1324 |
| Q27593307 | hsa-miR-15a-5p |
| Q27594548 | hsa-miR-15b-5p |
| Q27593305 | hsa-miR-16-5p |
| Q27593706 | hsa-miR-195-5p |
| Q27593222 | hsa-miR-26a-5p |
| Q27593245 | hsa-miR-331-5p |
| Q27594874 | hsa-miR-3943 |
| Q27593569 | hsa-miR-4313 |
| Q27593893 | hsa-miR-4319 |
| Q27593362 | hsa-miR-4503 |
| Q27592985 | hsa-miR-4678 |
| Q27593709 | hsa-miR-497-3p |
| Q27594600 | hsa-miR-574-3p |
| Q27593115 | hsa-miR-6751-3p |
| Q27593938 | hsa-miR-6792-5p |
| Q27595052 | hsa-miR-6847-3p |
| Q1088156 | chronic lymphocytic leukemia |
| Q105566932 | hair greying |
| Q945930 | progressive supranuclear palsy |
| Q18555943 | skin carcinoma |
| Q29892216 | Apoptosis |
| Q30225495 | B cell receptor signaling pathway |
| Q30230860 | Development of pulmonary dendritic cells and macrophage subsets |
| Q30225453 | Pre-implantation embryo |
| Q44017827 | Prion disease pathway |
| Q30230990 | T-cell receptor (TCR) signaling pathway |
| Q30230986 | Type II interferon signaling (IFNG) |
| Q44016322 | Vitamin D receptor pathway |
| Q30230877 | White fat cell differentiation |
| Q50399961 | White fat cell differentiation |
| Q21156369 | Interferon regulatory factor 4 | encoded by | P702 |
| cy | IRF4 | wikipedia |
| Interferon-regulierender Faktor 4 | wikipedia | |
| IRF4 | wikipedia | |
| IRF4 | wikipedia | |
| Persian (fa / Q9168) | IRF4 | wikipedia |
| IRF4 | wikipedia | |
| IRF4 | wikipedia | |
| Tatar language (tt / Q25285) | IRF4 | wikipedia |
| IRF4 | wikipedia |
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