Abstract is: 5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.
| P594 | Ensembl gene ID | ENSG00000131791 |
| P704 | Ensembl transcript ID | ENST00000254101 |
| ENST00000474939 | ||
| ENST00000496858 | ||
| P351 | Entrez Gene ID | 5565 |
| P2888 | exact match | http://identifiers.org/ncbigene/5565 |
| P646 | Freebase ID | /m/03gyvpm |
| P353 | HGNC gene symbol | PRKAB2 |
| P354 | HGNC ID | 9379 |
| P593 | HomoloGene ID | 38046 |
| P492 | OMIM ID | 602741 |
| 602741 | ||
| P639 | RefSeq RNA ID | NM_005399 |
| NR_103870 | ||
| NR_103871 | ||
| XM_011509729 | ||
| XM_047424538 | ||
| XM_047424539 | ||
| XM_047424544 | ||
| P2892 | UMLS CUI | C1418900 |
| P1057 | chromosome | human chromosome 1 | Q430258 |
| P4196 | cytogenetic location | 1q21.1 | |
| P688 | encodes | Protein kinase AMP-activated non-catalytic subunit beta 2 | Q21115150 |
| P5572 | expressed in | biceps brachii | Q201363 |
| gastrocnemius muscle | Q943203 | ||
| tibial arteries | Q7800442 | ||
| jejunal mucosa | Q30015772 | ||
| saphenous vein | Q30015816 | ||
| muscle of thigh | Q66514508 | ||
| body of tongue | Q66544432 | ||
| Skeletal muscle tissue of rectus abdominis | Q66601955 | ||
| Skeletal muscle tissue of biceps brachii | Q66601980 | ||
| buccal mucosa cell | Q116529247 | ||
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P645 | genomic end | 146644129 | |
| 147172550 | |||
| P644 | genomic start | 146626685 | |
| 147155106 | |||
| P684 | ortholog | aakb-1 | Q29695139 |
| aakb-2 | Q29706268 | ||
| prkab2 | Q29752756 | ||
| Prkab2 | Q18272894 | ||
| Prkab2 | Q24383775 | ||
| SIP2 | Q27542893 | ||
| P2548 | strand orientation | reverse strand | Q22809711 |
FileName: PBB GE PRKAB2 214474 at fs.png
Description: Gene expression pattern of the PRKAB2 gene.
Artist: AndrewGNF at English Wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
| Q27594287 | hsa-miR-103a-3p |
| Q27594284 | hsa-miR-1292-5p |
| Q27594733 | hsa-miR-146a-3p |
| Q27593305 | hsa-miR-16-5p |
| Q27592804 | hsa-miR-186-5p |
| Q27594161 | hsa-miR-216b-5p |
| Q27592899 | hsa-miR-29c-3p |
| Q27593812 | hsa-miR-301a-5p |
| Q27594389 | hsa-miR-301b-5p |
| Q27592771 | hsa-miR-30c-5p |
| Q27594835 | hsa-miR-3668 |
| Q27594515 | hsa-miR-3921 |
| Q27592714 | hsa-miR-4251 |
| Q27595263 | hsa-miR-4329 |
| Q27595012 | hsa-miR-4471 |
| Q27595290 | hsa-miR-450a-1-3p |
| Q27594915 | hsa-miR-4653-5p |
| Q27594687 | hsa-miR-4803 |
| Q27594046 | hsa-miR-515-5p |
| Q27594048 | hsa-miR-519e-5p |
| Q27595014 | hsa-miR-5680 |
| Q27594683 | hsa-miR-5687 |
| Q27594673 | hsa-miR-580-3p |
| Q27594965 | hsa-miR-597-3p |
| Q27593210 | hsa-miR-615-3p |
| Q27593263 | hsa-miR-6761-5p |
| Q27593803 | hsa-miR-8059 |
| Q102742988 | 1q21.1 copy number variation syndrome |
| Q30102296 | AMP-activated protein kinase (AMPK) signaling |
| Q30225526 | Angiopoietin-like protein 8 regulatory pathway |
| Q94664472 | Autophagy |
| Q50400559 | Caloric restriction and aging |
| Q54990710 | Genotoxicity pathway |
| Q62060067 | Hippo signaling regulation pathways |
| Q44011216 | Lipid metabolism pathway |
| Q109861217 | Malignant pleural mesothelioma |
| Q74069909 | Nonalcoholic fatty liver disease |
| Q30225458 | Sterol regulatory element-binding proteins (SREBP) signaling |
| Q62059922 | Synaptic signaling pathways associated with autism spectrum disorder |
| Q30225369 | Target of rapamycin (TOR) signaling |
| Q61996231 | Thermogenesis |
| Q30225378 | energy metabolism |
| Q102748172 | p53 transcriptional gene network |
| Q21115150 | Protein kinase AMP-activated non-catalytic subunit beta 2 | encoded by | P702 |
| cy | PRKAB2 | wikipedia |
| PRKAB2 | wikipedia | |
| Tatar language (tt / Q25285) | PRKAB2 | wikipedia |
| PRKAB2 | wikipedia |
Search more.