Abstract is: Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene. This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition. Furthermore, norbin protein expression is altered in the schizophrenia brain. Norbin also plays a role in regulating antimicrobial responses in neutrophils. Neurochondrin proteins induce hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain.
P594 | Ensembl gene ID | ENSG00000020129 |
P704 | Ensembl transcript ID | ENST00000356090 |
ENST00000373243 | ||
ENST00000373253 | ||
ENST00000423723 | ||
ENST00000437806 | ||
ENST00000459931 | ||
P351 | Entrez Gene ID | 23154 |
P2888 | exact match | http://identifiers.org/ncbigene/23154 |
P646 | Freebase ID | /m/04085yn |
P353 | HGNC gene symbol | NCDN |
P354 | HGNC ID | 17597 |
P593 | HomoloGene ID | 8064 |
P492 | OMIM ID | 608458 |
608458 | ||
P639 | RefSeq RNA ID | NM_001014839 |
NM_001014841 | ||
NM_014284 | ||
P2892 | UMLS CUI | C1538048 |
P1057 | chromosome | human chromosome 1 | Q430258 |
P4196 | cytogenetic location | 1p34.3 | |
P688 | encodes | Neurochondrin | Q22680286 |
P5572 | expressed in | putamen | Q550934 |
cingulate gyrus | Q1892702 | ||
middle frontal gyrus | Q3063753 | ||
superior frontal gyrus | Q3064113 | ||
Brodmann area 10 | Q3621943 | ||
postcentral gyrus | Q956517 | ||
caudate nucleus | Q1132309 | ||
nucleus accumbens | Q1476178 | ||
right frontal lobe | Q66570450 | ||
right hemisphere of cerebellum | Q66590413 | ||
P703 | found in taxon | Homo sapiens | Q15978631 |
P645 | genomic end | 35567274 | |
36032875 | |||
P644 | genomic start | 35557473 | |
36023074 | |||
P684 | ortholog | Neurochondrin | Q29728133 |
ncdn | Q29749046 | ||
Ncdn | Q18255803 | ||
Ncdn | Q24425442 | ||
P2548 | strand orientation | forward strand | Q22809680 |
FileName: PBB GE NCDN 209556 at fs.png
Description: Gene expression pattern of the NCDN gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE NCDN 209557 s at fs.png
Description: Gene expression pattern of the NCDN gene.
Artist: AndrewGNF at English Wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.