Abstract is: Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein that in humans is encoded by the ZFPM2 and in mice by the Zfpm2 gene. The zinc finger-containing protein encoded by this gene is a widely expressed member of the FOG family of regulators of transcription factors. The family consists of the ZFPM1 and ZFPM2 genes in humans and Zfpm1 and Zfpm2 genes in mice. Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors. That is, the ZFPM2 protein appears able to interact directly with and thereby either enhance or repress the ability of GATA transcription factors to stimulate the expression of their target genes; the direction of ZFPM2's actions depends on the contexts of the promoter sections of the various GATA target genes. The ZFPM2 protein interacts primarily with the GATA4 but also with GATA2, GATA5, and GATA6 transcription factors. ZFPM2 protein's interaction with GATA4 is notable for controlling the embryonic development of various tissues, particularly the heart, diaphragm, and gonads. Correspondingly, ZFPM2 mutations are responsible for certain forms of congenital heart defects, congenital diaphragmatic hernias, and ambiguous genitalia in mice as well as humans.
P594 | Ensembl gene ID | ENSG00000169946 |
P704 | Ensembl transcript ID | ENST00000407775 |
ENST00000511341 | ||
ENST00000517361 | ||
ENST00000518180 | ||
ENST00000520027 | ||
ENST00000520492 | ||
ENST00000521923 | ||
ENST00000522160 | ||
ENST00000522296 | ||
ENST00000524235 | ||
P351 | Entrez Gene ID | 23414 |
P2888 | exact match | http://identifiers.org/ncbigene/23414 |
P646 | Freebase ID | /m/03h04kv |
P353 | HGNC gene symbol | ZFPM2 |
P354 | HGNC ID | 16700 |
P593 | HomoloGene ID | 8008 |
P492 | OMIM ID | 603693 |
603693 | ||
P639 | RefSeq RNA ID | NM_001362836 |
NM_001362837 | ||
NM_012082 | ||
XM_011516947 | ||
P10376 | ScienceDirect topic ID | biochemistry-genetics-and-molecular-biology/zfpm2 |
P2892 | UMLS CUI | C1424490 |
P1057 | chromosome | human chromosome 8 | Q572848 |
P4196 | cytogenetic location | 8q23.1 | |
P688 | encodes | Zinc finger protein, FOG family member 2 | Q21107368 |
P5572 | expressed in | triceps brachii muscle | Q83379 |
pons | Q192570 | ||
vastus lateralis muscle | Q975459 | ||
germinal epithelium | Q1635319 | ||
glutes | Q2478147 | ||
parietal pleura | Q3508689 | ||
cardiac muscle tissue of right atrium | Q66502871 | ||
myocardium of left ventricle | Q66504996 | ||
cartilage tissue | Q66526729 | ||
Skeletal muscle tissue of biceps brachii | Q66601980 | ||
P703 | found in taxon | Homo sapiens | Q15978631 |
P2293 | genetic association | tuberculosis | Q12204 |
coronary artery disease | Q844935 | ||
tetralogy of Fallot | Q1126831 | ||
P645 | genomic end | 105804539 | |
106816760 | |||
P644 | genomic start | 104590733 | |
106330920 | |||
P684 | ortholog | Zfpm2 | Q18255477 |
Zfpm2 | Q24372495 | ||
zfpm2a | Q29778414 | ||
P2548 | strand orientation | forward strand | Q22809680 |
FileName: PBB GE ZFPM2 219778 at fs.png
Description: Gene expression pattern of the ZFPM2 gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE ZFPM2 219778 at tn.png
Description: Gene expression pattern of the ZFPM2 gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
Q21107368 | Zinc finger protein, FOG family member 2 | encoded by | P702 |
Q101405077 | human cardiomyocyte | has marker | P8872 |