PDGFC

protein-coding gene in the species Homo sapiens

DBpedia resource is: http://dbpedia.org/resource/PDGFC

Abstract is: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.

PDGFC is …

gene

protein-coding gene

External links are

P594	Ensembl gene ID	ENSG00000145431
P704	Ensembl transcript ID	ENST00000274071
		ENST00000422544
		ENST00000502773
		ENST00000504672
		ENST00000506880
		ENST00000510982
		ENST00000511985
		ENST00000512711
		ENST00000513664
P351	Entrez Gene ID	56034
P2888	exact match	http://identifiers.org/ncbigene/56034
P646	Freebase ID	/m/03gyw1n
P353	HGNC gene symbol	PDGFC
P354	HGNC ID	8801
P593	HomoloGene ID	9423
P6366	Microsoft Academic ID	2775968144
P492	OMIM ID	608452
		608452
P639	RefSeq RNA ID	NM_016205
		NR_036641
		XM_011532124
		XM_017008455
		XM_017008456
P2892	UMLS CUI	C1418436

P1057	chromosome	human chromosome 4	Q836605
P4196	cytogenetic location	4q32.1
P688	encodes	Platelet derived growth factor C	Q21123252
		Platelet-derived growth factor C	Q21146829
P5572	expressed in	tibia	Q178366
		seminal vesicula	Q217259
		periodontal fiber	Q540092
		germinal epithelium	Q1635319
		parietal pleura	Q3508689
		kidney tubule	Q11465565
		parotid gland	Q691653
		metanephric glomerulus	Q30030409
		skin of hip	Q66535707
		stromal cell of endometrium	Q66592424
P703	found in taxon	Homo sapiens	Q15978631
P645	genomic end	156971799
		157892546
P644	genomic start	156760454
		157681606
P684	ortholog	Pdgfc	Q18258176
		Pdgfc	Q24406972
		pdgfc	Q29777860
P2548	strand orientation	reverse strand	Q22809711

Wikimedia Commons Images

P692: Gene Atlas image

FileName: PBB GE PDGFC 218718 at fs.png

Description: Gene expression pattern of the PDGFC gene.

Artist: AndrewGNF at English Wikipedia

Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.

P692: Gene Atlas image

FileName: PBB GE PDGFC gnf1h09218 s at fs.png

Description: Gene expression pattern of the PDGFC gene.

Artist: AndrewGNF at English Wikipedia

Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.

Reverse relations

regulates (molecular biology) (P128)

Q27594338	hsa-miR-124-3p
Q27592900	hsa-miR-29b-3p
Q27594255	hsa-miR-375
Q27593210	hsa-miR-615-3p
Q27593582	hsa-miR-7-5p

has part(s) (P527)

Q102733920	EGFR tyrosine kinase inhibitor resistance
Q30151288	Focal adhesion
Q30230865	Focal adhesion: PI3K-Akt-mTOR-signaling pathway
Q109861217	Malignant pleural mesothelioma
Q50400941	PI3K-Akt signaling pathway

ortholog (P684)

Q18258176	Pdgfc
Q24406972	Pdgfc
Q29777860	pdgfc

encoded by (P702)

Q21123252	Platelet derived growth factor C
Q21146829	Platelet-derived growth factor C