Abstract is: Potassium-chloride transporter member 5 (aka: KCC2 and SLC12A5) is a neuron-specific chloride potassium symporter responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations. It is a critical mediator of synaptic inhibition, cellular protection against excitotoxicity and may also act as a modulator of neuroplasticity. Potassium-chloride transporter member 5 is also known by the names: KCC2 (potassium chloride cotransporter 2) for its ionic substrates, and SLC12A5 for its genetic origin from the SLC12A5 gene in humans. Animals with reduced expression of this transporter exhibit severe motor deficits, epileptiform activity, and spasticity. KCC2 knockout animals, in which KCC2 is completely absent, die postnatally due to respiratory failure.
| P594 | Ensembl gene ID | ENSG00000124140 |
| P704 | Ensembl transcript ID | ENST00000243964 |
| ENST00000372315 | ||
| ENST00000413737 | ||
| ENST00000428198 | ||
| ENST00000454036 | ||
| ENST00000539566 | ||
| ENST00000608594 | ||
| ENST00000608944 | ||
| ENST00000616202 | ||
| ENST00000616933 | ||
| ENST00000622711 | ||
| ENST00000625683 | ||
| ENST00000626144 | ||
| ENST00000626695 | ||
| ENST00000626701 | ||
| ENST00000626937 | ||
| ENST00000627290 | ||
| ENST00000628272 | ||
| ENST00000628413 | ||
| ENST00000629054 | ||
| ENST00000636324 | ||
| ENST00000637437 | ||
| ENST00000637831 | ||
| ENST00000637863 | ||
| P351 | Entrez Gene ID | 57468 |
| P2888 | exact match | http://identifiers.org/ncbigene/57468 |
| P646 | Freebase ID | /m/03h00lg |
| P353 | HGNC gene symbol | SLC12A5 |
| P354 | HGNC ID | 13818 |
| P593 | HomoloGene ID | 10665 |
| P492 | OMIM ID | 606726 |
| 606726 | ||
| P639 | RefSeq RNA ID | NM_001134771 |
| NM_020708 | ||
| P2892 | UMLS CUI | C1422213 |
| P1057 | chromosome | human chromosome 20 | Q666752 |
| P4196 | cytogenetic location | 20q13.12 | |
| P688 | encodes | Solute carrier family 12 member 5 | Q21124433 |
| Solute carrier family 12 member 5 | Q21147141 | ||
| P5572 | expressed in | lateral nuclear group of thalamus | Q66558397 |
| right hemisphere of cerebellum | Q66590413 | ||
| orbitofrontal cortex | Q18717 | ||
| dorsolateral prefrontal cortex | Q72788 | ||
| superior frontal gyrus | Q3064113 | ||
| Brodmann area 10 | Q3621943 | ||
| Brodmann area 23 | Q4973067 | ||
| Brodmann area 9 | Q4973099 | ||
| frontal pole | Q11397859 | ||
| primary visual cortex | Q66531315 | ||
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P645 | genomic end | 44688784 | |
| 46060150 | |||
| P644 | genomic start | 44650356 | |
| 46021690 | |||
| P684 | ortholog | Slc12a5 | Q18258682 |
| Slc12a5 | Q24384249 | ||
| si:ch211-59d13.2 | Q29751455 | ||
| slc12a5b | Q29777251 | ||
| P2548 | strand orientation | forward strand | Q22809680 |
FileName: PBB GE SLC12A5 210040 at fs.png
Description: Gene expression pattern of the SLC12A5 gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
| Q27593104 | hsa-miR-1237-5p |
| Q27593498 | hsa-miR-203a-3p |
| Q27595338 | hsa-miR-224-5p |
| Q27594696 | hsa-miR-2277-3p |
| Q27594904 | hsa-miR-25-3p |
| Q27593618 | hsa-miR-3178 |
| Q27595127 | hsa-miR-32-5p |
| Q27593663 | hsa-miR-328-5p |
| Q27593804 | hsa-miR-3614-5p |
| Q27595278 | hsa-miR-363-3p |
| Q27594623 | hsa-miR-367-3p |
| Q27594917 | hsa-miR-4285 |
| Q27593569 | hsa-miR-4313 |
| Q27594323 | hsa-miR-4325 |
| Q27593409 | hsa-miR-433-5p |
| Q27594168 | hsa-miR-4433a-5p |
| Q27594165 | hsa-miR-4433b-5p |
| Q27594994 | hsa-miR-4469 |
| Q27595176 | hsa-miR-4479 |
| Q27593089 | hsa-miR-4488 |
| Q27594777 | hsa-miR-4646-3p |
| Q27595085 | hsa-miR-4667-3p |
| Q27593183 | hsa-miR-4697-5p |
| Q27593761 | hsa-miR-4726-3p |
| Q27594489 | hsa-miR-5193 |
| Q27595293 | hsa-miR-542-3p |
| Q27595020 | hsa-miR-548az-5p |
| Q27594872 | hsa-miR-548n |
| Q27594652 | hsa-miR-548t-5p |
| Q27594661 | hsa-miR-6075 |
| Q27592784 | hsa-miR-6500-3p |
| Q27593111 | hsa-miR-6749-3p |
| Q27594912 | hsa-miR-6840-3p |
| Q27593930 | hsa-miR-6885-5p |
| Q27593986 | hsa-miR-6887-3p |
| Q27593357 | hsa-miR-7703 |
| Q27593334 | hsa-miR-92a-3p |
| Q27592842 | hsa-miR-92b-3p |
| Q101404913 | human Purkinje neuron |
| Q101405067 | human immature neuron |
| Q101405035 | human interneuron |
| Q101405104 | human neuron |
| Q55784956 | epileptic encephalopathy, early infantile, 34; EIEE34 | genetic association | P2293 |
| Q87829374 | mBDNF and proBDNF regulation of GABA neurotransmission | has part(s) | P527 |