Abstract is: Belimumab, sold under the brand name Benlysta, is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). It is approved in the United States, Canada, and the European Union to treat systemic lupus erythematosus (SLE). The most common side effects include bacterial infections, such as bronchitis (infection in the lungs) and infection of the urinary tract (structures that produce or carry urine), diarrhea and nausea (feeling sick). Infections may be more likely in younger children.
P267 | ATC code | L04AA26 |
P231 | CAS Registry Number | 356547-88-1 |
P592 | ChEMBL ID | CHEMBL1789843 |
P715 | DrugBank ID | DB08879 |
P10565 | Encyclopedia of China (Third Edition) ID | 632926 |
P646 | Freebase ID | /m/027yjt9 |
P595 | Guide to Pharmacology Ligand ID | 6887 |
P8408 | KBpedia ID | Belimumab |
P665 | KEGG ID | D03068 |
P7830 | LiverTox ID | Belimumab |
P10245 | MedlinePlus drug identifier | a611027 |
P486 | MeSH descriptor ID | C511911 |
P6366 | Microsoft Academic ID | 2781205201 |
P2115 | NDF-RT ID | N0000182640 |
P10283 | OpenAlex ID | C2781205201 |
P4235 | PatientsLikeMe treatment ID | belimumab |
P3345 | RxNorm ID | 1092437 |
P652 | UNII | 73B0K5S26A |
P11143 | WikiProjectMed ID | Belimumab |
P3350 | World Health Organisation international non-proprietary name numeric ID | 8381 |
P3780 | active ingredient in | Benlysta | Q29004890 |
P4250 | defined daily dose | 25 | |
P1552 | has characteristic | biopharmaceutical | Q679692 |
P366 | has use | medication | Q12140 |
P8026 | LiverTox likelihood score | LiverTox toxicity likelihood category E | Q83284667 |
P2175 | medical condition treated | lupus nephritis | Q1621830 |
P129 | physically interacts with | TNF superfamily member 13b | Q409346 |
P3489 | pregnancy category | US pregnancy category C | Q28123617 |
P2868 | subject has role | immunosuppressive drug | Q249619 |
monoclonal antibody | Q422248 | ||
P2275 | World Health Organisation international non-proprietary name | belimumab |
Description: Space-filling model of the monoclonal antibody belimumab (Fab).
Style made to resemble the Protein Data Bank's "Molecule of the Month" series, illustrated by Dr. David S. Goodsell of the Scripps Research Institute. Created using QuteMol (http://qutemol.sourceforge.net) and GIMP. Optimized with OptiPNG.
Artist: Fvasconcellos (talk · contribs)
License: Public domain
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Q35761089 | Efficacy, pharmacokinetic and pharmacodynamic profile of belimumab for systemic lupus erythematosus |
Q98575505 | Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial |
Q36672666 | Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab |
Q90891574 | Established organ damage reduces belimumab efficacy in systemic lupus erythematosus |
Q89241748 | Evaluation of Use of Belimumab In Clinical Practice Settings (Observe Study) In Spain: Health Resource Utilization and Labour Absenteeism |
Q95537033 | Evaluation of a novel autoinjector for subcutaneous self-administration of belimumab in systemic lupus erythematosus |
Q98462463 | Evaluation of belimumab treatment in patients with systemic lupus erythematosus in a clinical practice setting: Results from a 24-month OBSErve study in Argentina |
Q96639346 | Exposure to Belimumab in the First Trimester of Pregnancy in a Young Woman With Systemic Lupus Erythematosus |
Q89182146 | Favorable pregnancy outcome in a patient with systemic lupus erythematosus treated with belimumab: A confirmation report |
Q30490276 | First Real-World Insights into Belimumab Use and Outcomes in Routine Clinical Care of Systemic Lupus Erythematosus in Germany: Results from the OBSErve Germany Study. |
Q28183674 | Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator |
Q34114253 | Health technology assessment of belimumab: a new monoclonal antibody for the treatment of systemic lupus erythematosus |
Q60913872 | Impact of belimumab on patient-reported outcomes in systemic lupus erythematosus: review of clinical studies |
Q37384403 | Impact of concomitant medication use on belimumab efficacy and safety in patients with systemic lupus erythematosus |
Q37715948 | Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials |
Q91554193 | Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus |
Q94472394 | Influenza vaccine in patients on biological therapy; also with belimumab |
Q59791466 | Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab |
Q48504730 | Long-Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus: A Continuation of a Seventy-Six-Week Phase III Parent Study in the United States |
Q96766194 | Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results |
Q57461365 | Long-term impact of belimumab on health-related quality of life and fatigue in patients with systemic lupus erythematosus: 6 years of treatment |
Q37121787 | Long-term organ damage accrual and safety in patients with SLE treated with belimumab plus standard of care |
Q91856866 | Long-term safety and limited organ damage in patients with systemic lupus erythematosus treated with belimumab: a Phase III study extension |
Q42652135 | Long-term safety profile of belimumab plus standard therapy in patients with systemic lupus erythematosus |
Q51738271 | Low disease activity-irrespective of serologic status at baseline-associated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: A real-life observational study. |
Q36027561 | Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjögren's syndrome: results of the BELISS study |
Q91209271 | Lupus Low Disease Activity State (LLDAS) discriminates responders in the BLISS-52 and BLISS-76 phase III trials of belimumab in systemic lupus erythematosus |
Q50118147 | Lupus erythematosus treatment with belimumab in daily practice: Retrospective study of 15 patients |
Q98472136 | Lupus low disease activity (SLE) in patients treated with belimumab: a single-center real-life experience (2016-2019) |
Q98179037 | Lupus-associated protein losing enteropathy (LUPLE) complicated by a hypercoagulable state and successfully treated with belimumab |
Q88204200 | Lymphocyte changes and vaccination response in a child exposed to belimumab during pregnancy |
Q96952828 | Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab |
Q35566828 | Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis. |
Q99725012 | Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia |
Q84068974 | New drugs. Azilsartan medoxomil, belimumab, and lurasidone hydrochloride |
Q57789397 | OP0302 Significant reductions of pathogenic autoantibodies by synergetic rituximab and belimumab treatment effectively inhibits neutrophil extracellular traps in severe, refractory sle - the synbiose study |
Q64229203 | Organ damage in patients treated with belimumab versus standard of care: a propensity score-matched comparative analysis |
Q92745817 | Organ system improvements in Japanese patients with systemic lupus erythematosus treated with belimumab: A subgroup analysis from a phase 3 randomized placebo-controlled trial |
Q47624115 | Patient Evaluation of Satisfaction and Outcomes with an Autoinjector for Self-Administration of Subcutaneous Belimumab in Patients with Systemic Lupus Erythematosus |
Q91736978 | Patient Satisfaction And Disease Control In Patients With Systemic Lupus Erythematosus Is Not Affected By Switching From Intravenous Belimumab To Subcutaneous Injections |
Q91782881 | Pharmacogenetic analysis of belimumab fails to identify robust genetic predictors of efficacy in lupus |
Q103017434 | Pharmacokinetics of Belimumab in Children With Systemic Lupus Erythematosus |
Q92742184 | Pharmacokinetics, Pharmacodynamics and Safety of Belimumab in Chinese Patients with Systemic Lupus Erythematosus: A Phase I, Open-Label Study |
Q64069128 | Phase III, multicentre, randomised, double-blind, placebo-controlled, 104-week study of subcutaneous belimumab administered in combination with rituximab in adults with systemic lupus erythematosus (SLE): BLISS-BELIEVE study protocol |
Q48010137 | Population Pharmacokinetic and Pharmacodynamic Analysis of Belimumab Administered Subcutaneously in Healthy Volunteers and Patients with Systemic Lupus Erythematosus |
Q43529181 | Population pharmacokinetics of belimumab following intravenous administration in patients with systemic lupus erythematosus |
Q38230701 | Post-marketing experiences with belimumab in the treatment of SLE patients |
Q92485957 | Predictors of low disease activity and clinical remission following belimumab treatment in systemic lupus erythematosus |
Q48302795 | Progressive multifocal leukoencephalopathy associated with belimumab in a patient with systemic lupus erythematosus |
Q55267717 | Randomized study of adjunctive belimumab in participants with generalized myasthenia gravis. |
Q39953054 | Real life experience on the effect of Belimumab in patients with active systemic lupus |
Q102147270 | Real-World Effectiveness of Belimumab in the Treatment of Systemic Lupus Erythematosus: Pooled Analysis of Multi-Country Data from the OBSErve Studies |
Q93271975 | Real-world treatment patterns, healthcare resource utilisation and costs in patients with systemic lupus erythematosus treated with belimumab: a retrospective analysis of claims data in the USA |
Q56907345 | Recomendaciones sobre el uso de belimumab en el lupus eritematoso sistémico. Guía de Práctica Clínica GEAS-SEMI |
Q45122982 | Recommendation for use of belimumab for systemic lupus erythematosus |
Q85275853 | Refractory subacute cutaneous lupus erythematous responding to a single course of belimumab: a new anti-BLyS human monoclonal antibody |
Q37337375 | Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects |
Q36472640 | Response to belimumab among patients with systemic lupus erythematosus in clinical practice settings: 24-month results from the OBSErve study in the USA. |
Q91720949 | Response to: 'Achieving lupus low disease activity and remission states under belimumab in refractory systemic lupuserythematosus: time and organ involvement matter' by Sbeih et al |
Q102069135 | Rituximab Followed by Belimumab Controls Severe Lupus Nephritis and Bullous Pemphigoid in Systemic Lupus Erythematosus Refractory to Several Combination Therapies |
Q103041670 | Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study |
Q95552844 | Rituximab-refractory lupus nephritis successfully treated with belimumab |
Q57789401 | SAT0258 Synergetic b-cell immunomodulation with rituximab and belimumab is clinically effective in severe and refractory systemic lupus erythematosus – the synbiose proof-of-concept study |
Q91640209 | Safety and Efficacy of Belimumab Plus Standard Therapy for Up to Thirteen Years in Patients With Systemic Lupus Erythematosus |
Q37272264 | Safety and Efficacy of Belimumab to Treat Systemic Lupus Erythematosus in Academic Clinical Practices |
Q97546502 | Safety and efficacy of belimumab after B cell depletion therapy in systemic LUPUS erythematosus (BEAT-LUPUS) trial: statistical analysis plan |
Q97652337 | Safety and efficacy of intravenous belimumab in children with systemic lupus erythematosus: results from a randomised, placebo-controlled trial |
Q30580226 | Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus |
Q37077223 | Safety, tolerability, pharmacokinetics and pharmacodynamics of belimumab in Japanese patients with mild-to-moderate systemic lupus erythematosus |
Q95358443 | Sequential therapy with belimumab followed by rituximab in Sjögren's syndrome associated with B-cell lymphoproliferation and overexpression of BAFF: evidence for long-term efficacy |
Q39143034 | Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus |
Q89351208 | Smoking reduces the efficacy of belimumab in mucocutaneous lupus |
Q38605480 | Subcutaneous and intravenous belimumab in the treatment of systemic lupus erythematosus: a review of data on subcutaneous and intravenous administration |
Q90935648 | Subcutaneous belimumab in the treatment of systemic lupus erythematosus |
Q59789656 | Subcutaneous formulation of belimumab in treatment of systemic lupus erythematosus: a critical review with focus on safety and satisfaction |
Q51164426 | Successful application of belimumab in two patients with systemic lupus erythematosus experiencing a flare during tocilizumab treatment. |
Q52658159 | Successful sequential therapy with rituximab and belimumab in patients with active systemic lupus erythematosus: a case series. |
Q44050390 | Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman |
Q89309517 | Successful treatment of refractory lupus nephritis by the sequential use of rituximab and belimumab |
Q51152275 | Successful treatment of refractory systemic lupus erythematosus using proteasome inhibitor bortezomib followed by belimumab: description of two cases. |
Q92308423 | Successful treatment of systemic lupus erythematosus pleuropericarditis with belimumab |
Q104582839 | Systematic review of safety and efficacy of belimumab in treating immune-mediated disorders |
Q38948425 | Systemic lupus erythematosus exacerbation following cessation of belimumab treatment |
Q51104713 | Systemic lupus erythematous exacerbation following cessation of belimumab treatment: comments on the article by Furer et al. |
Q90585211 | The Impact of Belimumab and Rituximab on Health-Related Quality of Life in Patients With Systemic Lupus Erythematosus |
Q52595520 | The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus. |
Q35691272 | The discovery and development of belimumab: the anti-BLyS-lupus connection |
Q42622871 | The pharmacokinetics and safety profiles of belimumab after single subcutaneous and intravenous doses in healthy Japanese volunteers |
Q40232762 | The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales |
Q40183925 | The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales. |
Q94517994 | The role of baseline BLyS levels and type 1 interferon-inducible gene signature status in determining belimumab response in systemic lupus erythematosus: a post hoc meta-analysis |
Q90969407 | The safety of belimumab for the treatment of systemic lupus erythematosus |
Q40246614 | Treatment with belimumab in systemic lupus erythematosus does not impair antibody response to 13-valent pneumococcal conjugate vaccine |
Q50748403 | Treatment with belimumab restores B cell subsets and their expression of B cell activating factor receptor in patients with primary Sjogren's syndrome. |
Q99554983 | Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis |
Q50851171 | Type I interferon signature may influence the effect of belimumab on immunoglobulin levels, including rheumatoid factor in Sjögren's syndrome. |
Q38258871 | Update on belimumab for the management of systemic lupus erythematosus |
Q38344444 | Use of B lymphocyte stimulator inhibitor belimumab may be associated with a decrease in the serum concentration of epidermal growth factor in patients with primary Sjögren's syndrome |
Q50231398 | Use of Belimumab throughout 2 Consecutive Pregnancies in a Patient with Systemic Lupus Erythematosus. |
Q38227435 | Use of belimumab throughout pregnancy to treat active systemic lupus erythematosus: a case report |
Q54113599 | When to use belimumab in SLE. |
Q95809611 | [Belimumab in systemic lupus erythematosus: a guide for its use in the daily practice] |
Q53493843 | [Cost-effectiveness analysis of Belimumab in patients with systemic lupus erythematosus in Spain]. |
Q80644952 | [Human monoclonal antibody to B-lymphocyte stimulator (belimumab) and humanized anti-LFA-1 monoclonal antibodies (efalizumab)] |
Q92929406 | [Resistant and progressive cutaneous lupus erythematosus treated with belimumab: A retrospective monocentric study] |
Q409346 | TNF superfamily member 13b | physically interacts with | P129 |
Q1621830 | lupus nephritis | drug or therapy used for treatment | P2176 |
Q29004890 | Benlysta | has active ingredient | P3781 |
Category:Belimumab | wikimedia | |
Arabic (ar / Q13955) | بيليموماب | wikipedia |
azb | بلیموماب | wikipedia |
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