belimumab

pharmaceutical drug

DBpedia resource is: http://dbpedia.org/resource/Belimumab

Abstract is: Belimumab, sold under the brand name Benlysta, is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). It is approved in the United States, Canada, and the European Union to treat systemic lupus erythematosus (SLE). The most common side effects include bacterial infections, such as bronchitis (infection in the lungs) and infection of the urinary tract (structures that produce or carry urine), diarrhea and nausea (feeling sick). Infections may be more likely in younger children.

Wikimedia Commons category is Belimumab

C₆₇₁₄H₁₀₄₂₈O₂₁₀₂S₅₂

belimumab is …
instance of (P31):
type of chemical entityQ113145171

sublass of (P279):
chemical compoundQ11173

External links are
P267ATC codeL04AA26
P231CAS Registry Number356547-88-1
P592ChEMBL IDCHEMBL1789843
P715DrugBank IDDB08879
P10565Encyclopedia of China (Third Edition) ID632926
P646Freebase ID/m/027yjt9
P595Guide to Pharmacology Ligand ID6887
P8408KBpedia IDBelimumab
P665KEGG IDD03068
P7830LiverTox IDBelimumab
P10245MedlinePlus drug identifiera611027
P486MeSH descriptor IDC511911
P6366Microsoft Academic ID2781205201
P2115NDF-RT IDN0000182640
P10283OpenAlex IDC2781205201
P4235PatientsLikeMe treatment IDbelimumab
P3345RxNorm ID1092437
P652UNII73B0K5S26A
P11143WikiProjectMed IDBelimumab
P3350World Health Organisation international non-proprietary name numeric ID8381

P3780active ingredient inBenlystaQ29004890
P4250defined daily dose25
P1552has characteristicbiopharmaceuticalQ679692
P366has usemedicationQ12140
P8026LiverTox likelihood scoreLiverTox toxicity likelihood category EQ83284667
P2175medical condition treatedlupus nephritisQ1621830
P129physically interacts withTNF superfamily member 13bQ409346
P3489pregnancy categoryUS pregnancy category CQ28123617
P2868subject has roleimmunosuppressive drugQ249619
monoclonal antibodyQ422248
P2275World Health Organisation international non-proprietary namebelimumab

Wikimedia Commons Images

P6802: related image


FileName: Belimumab 5Y9K.png

Description: Space-filling model of the monoclonal antibody belimumab (Fab).
Style made to resemble the Protein Data Bank's "Molecule of the Month" series, illustrated by Dr. David S. Goodsell of the Scripps Research Institute. Created using QuteMol (http://qutemol.sourceforge.net) and GIMP. Optimized with OptiPNG.

Artist: Fvasconcellos (talk · contribs)

License: Public domain

Reverse relations

research intervention (P4844)
Q64040335A Continuation Trial for Subjects With Lupus That Completed Protocol HGS1006-C1056 or HGS1006-C1057
Q64716858A Continuation Trial for Subjects With Lupus Who Completed Protocol HGS1006-C1056 in the United States
Q64726467A Continuation Trial for Subjects With Rheumatoid Arthritis That Have Completed Protocol LBRA01
Q64726490A Continuation Trial for Subjects With Systemic Lupus Erythematosus That Have Completed Protocol LBSL02
Q113917758A Model About the Response of Belimumab in SLE
Q65360076A Phase 2B Open-Label, Single-Arm, Repeat-Dose Study to Evaluate the Reliability of an Autoinjector
Q65367022A Pooled Analysis of the HGS1006-C1056 (BLISS-52) and HGS1006-C1057 (BLISS-76) Studies
Q66034274A Safety and Efficacy Study of LymphoStat-B™ (Monoclonal Anti-BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA)
Q113894288A Study Validating the Use of Candin as a Challenge Agent in Healthy Participants - Intervention Specific Appendix 2
Q65375007A Study of Belimumab Administered Subcutaneously in Subjects With Systemic Lupus Erythematosus (SLE)
Q64645092A Study of Belimumab in Idiopathic Membranous Glomerulonephropathy
Q65385430A Study of Belimumab in Subjects With Systemic Lupus Erythematosus
Q61921600A Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)
Q63832168A Study of Belimumab in Treating Symptomatic Waldenstroms Macroglobulinaemia
Q63320368A Study of Belimumab in the Prevention of Kidney Transplant Rejection
Q65363862A Study to Estimate the Relative Bioavailability, Tolerability and Safety of a Single Dose of Belimumab Self-Administered Subcutaneously (SC) by Healthy Subjects
Q63842121A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE)
Q63571342A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximab to Adult Subjects With Systemic Lupus Erythematosus (SLE) - BLISS-BELIEVE
Q63322522A Study to Investigate Belimumab for the Treatment of Chronic Immune Thrombocytopenia.
Q113915741Addition of Belimumab to B-cell Depletion in Relapsing-remitting Multiple Sclerosis
Q64184564BAFF and APRIL and RESPONSE TO BELIMUMAB in SLE
Q63842072BEL114333, a Continuation Study of BEL113750 in Subjects With Systemic Lupus Erythematosus (SLE) in Northeast Asia, and in Japan Subjects Completing the Open-label Extension of HGS1006-C1115
Q64806583BENLYSTA® Special Drug Use Investigation
Q63316482Belimumab (BENLYSTA®) Pregnancy Registry
Q64639607Belimumab Assessment of Safety in SLE
Q64189000Belimumab Impacting Transplant Eligibility
Q107508019Belimumab In Treatment of Early Systemic Lupus Erythematosus
Q66082454Belimumab Phase I Study in Chinese Subjects With Systemic Lupus Erythematosus
Q67134625Belimumab Treatment Holiday and Treatment Re-start Study in Lupus Patients
Q105493836Belimumab Treatment for IgG4-related Disease
Q66068751Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies
Q64122064Belimumab With Rituximab for Primary Membranous Nephropathy
Q64794549Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Q66071324Belimumab for Prevention of Chronic Graft-versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation
Q64641860Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Q67129668Belimumab in Idiopathic Inflammatory Myositis
Q113939437Belimumab in Patients With Chronic Lymphocytic Leukemia
Q63838526Belimumab in Remission of VASculitis
Q64122434CAMPath and BELimumab for Transplant Tolerance in Sensitized Kidney Transplant Recipients
Q66045302Compassionate Use for Subcutaneous (SC) Belimumab
Q64683947Desensitization With Belimumab in Sensitized Patients Awaiting Kidney Transplant
Q64621562Effectiveness of Belimumab Treatment in a Subpopulation of Systemic Lupus Erythematosus (SLE) Patients: a Pooled Analysis of BLISS-52 and BLISS-76
Q113943242Efficacy and Immunological Evaluation of Belimumab Plus Low Dose IL-2 in the Treatment of Systemic Lupus Erythematosus
Q61909747Efficacy and Safety Assessment of a Treatment Combining Rituximab and Belimumab in Adults With Persistent Immune Thrombocytopenia
Q63845088Efficacy and Safety Study of Intravenous Belimumab Versus Placebo in Subjects With Idiopathic Membranous Nephropathy
Q64643511Efficacy and Safety of Belimumab in Black Race Patients With Systemic Lupus Erythematosus (SLE)
Q113931297Efficacy and Safety of Belimumab in Neuromyelitis Optica Spectrum Disorders
Q64189304Efficacy and Safety of Belimumab in Patients With Active Lupus Nephritis
Q64660248Efficacy and Safety of Belimumab in Primary Sjögren's Syndrome
Q106637768Efficacy and Safety of Belimumab in SLE Patients
Q63834237Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome
Q64601423Evaluation of Belimumab Impact on a BLyS Activity Signature Test in the Absence of Confounding Polypharmacy
Q64673677Expanded Access Trial of Belimumab Antibody in RA Patients Who Were Previously Treated Under HGS Protocol LBRA99
Q63336423GSK1550188 A 52 Week Study of Belimumab Versus Placebo in the Treatment of Subjects With Systemic Lupus Erythematosus (SLE) Located in Northeast Asia
Q64645806Japanese phase1 Study of Belimumab (IV vs SC)
Q113895123Multicenter Randomized Double-blind Study Comparing the Efficacy and Safety of Belimumab in the Treatment of Non-infectious Active Cryoglobulinemia Vasculitis Compared to Placebo. TRIBECA STUDY (Treatment nd BElimumab in Cryoglobulinemia Associa
Q113918407Open-label Study of Belimumab Plus Standard Therapy in Chinese Pediatric Participants With Active Systemic Lupus Erythematosus (SLE)
Q63839145Pediatric Lupus Trial of Belimumab Plus Background Standard Therapy
Q64719576Phase 1 Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)
Q64717325Phase 2 Study of Belimumab Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus (SLE)
Q66065662Rituximab and Belimumab Combination Therapy in PR3 COMBIVAS
Q64601390Rituximab and Belimumab for Lupus Nephritis
Q64651252Safety and Effectiveness of Belimumab in Systemic Lupus Erythematosus Registry
Q66034353Safety and Efficacy Study of LymphoStat-B (Belimumab) in Subjects With Systemic Lupus Erythematosus (SLE)
Q66410491Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome
Q74283157Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)
Q97047839Sequential Belimumab and T-cell Based Therapy in SLE
Q74274327Single Dose Study to Investigate the Pharmacokinetics (PK) and Safety of Belimumab 200 Milligrams (mg) Intravenous and 200 mg Subcutaneous Via Auto-injector in Chinese Healthy Subjects
Q64644095Study of Belimumab Administered Subcutaneously to Healthy Subjects
Q76981423Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)
Q64614232Synergetic B-cell Immodulation in SLE
Q62034355Synergetic B-cell Immunomodulation in SLE - 2nd Study.
Q65375198The Evaluation of Belimumab in Myasthenia Gravis (MG)
Q104675545Transcriptional and Immine Parameters of Response to Belinumab
Q62810978Trial of Belimumab in Early Lupus

main subject (P921)
Q88883573A 6-month open-label extension study of the safety and efficacy of subcutaneous belimumab in patients with systemic lupus erythematosus
Q57243651A Randomized Controlled Trial of Belimumab for the Treatment of Active Systemic Lupus Erythematosus
Q40345289A Retrospective Administrative Claims Database Evaluation of the Utilization of Belimumab in US Managed Care Settings
Q38944472A Review of Clinical Trials of Belimumab in the Management of Systemic Lupus Erythematosus.
Q99710372A case of systemic lupus erythematosus/systemic sclerosis overlap syndrome successfully treated with belimumab
Q92656085A case with good response to belimumab for lupus nephritis complicated by IgG4-related disease
Q37378350A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
Q28254310A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus
Q49359821A pivotal phase III, randomised, placebo-controlled study of belimumab in patients with systemic lupus erythematosus located in China, Japan and South Korea
Q47116737A randomized, open-label study to investigate the effect of belimumab on pneumococcal vaccination in patients with active, autoantibody-positive systemic lupus erythematosus
Q34394509A rare case of prototheca algaemia in a patient with systemic lupus erythematosus and recent belimumab infusion
Q92727505A reverse translational study on the effect of rituximab, rituximab plus belimumab, or bortezomib on the humoral autoimmune response in SLE
Q43961548A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia.
Q91720943Achieving lupus low-disease activity and remission states under belimumab in refractory systemic lupus erythematosus: time and organ involvement matter
Q100386043Adding belimumab improves lupus nephritis
Q92559285Alopecia areata in patients with systemic lupus erythematosus treated with belimumab: a plausible association
Q53071532An indirect comparison of intravenous and subcutaneous belimumab efficacy in patients with SLE and high disease activity.
Q37850690An update on belimumab for the treatment of lupus
Q64045422Anticardiolipin and anti-beta 2 glycoprotein-I antibodies disappearance in patients with systemic lupus erythematosus and antiphospholipid syndrome while on belimumab
Q35816153Assessment of the Economic Impact of Belimumab for the Treatment of Systemic Lupus Erythematosus in the Italian Setting: A Cost-Effectiveness Analysis
Q64088568Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab
Q95304723Autoantibody and Cytokine Profiles during Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
Q90795990B cell alterations during BAFF inhibition with belimumab in SLE
Q102056363B-cell depletion or belimumab or voclosporin for lupus nephritis?
Q52639397BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus.
Q39132754BUDGET IMPACT ANALYSIS OF BELIMUMAB IN TREATING SYSTEMIC LUPUS ERYTHEMATOSUS.
Q30645037Baseline predictors of systemic lupus erythematosus flares: data from the combined placebo groups in the phase III belimumab trials
Q84324262Belimumab (Benlysta) for systemic lupus eruthematosus
Q35958642Belimumab (benlysta): a breakthrough therapy for systemic lupus erythematosus
Q93190907Belimumab Concentrations in Maternal Serum and Breast Milk During Breastfeeding and the Safety Assessment of the Infant: A Case Study
Q83857457Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline
Q95598742Belimumab Treatment for Adults with Systemic Lupus Erythematosus: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
Q92057326Belimumab after B cell depletion therapy in patients with systemic lupus erythematosus (BEAT Lupus) protocol: a prospective multicentre, double-blind, randomised, placebo-controlled, 52-week phase II clinical trial
Q57789612Belimumab after rituximab as maintenance therapy in lupus nephritis
Q92688703Belimumab alters transitional B-cell subset proportions in patients with stable systemic lupus erythematosus
Q97646117Belimumab and Rituximab in Systemic Lupus Erythematosus: A Tale of Two B Cell-Targeting Agents
Q50040141Belimumab and antipneumococcal vaccination in patients with systemic lupus erythematosus
Q54948758Belimumab and low-doses of mycophenolate mofetil as induction therapy of class IV lupus nephritis: case series and literature review.
Q34276645Belimumab and the clinical data
Q50936841Belimumab and the measurement of fatigue.
Q99554992Belimumab as Add-on Therapy in Lupus Nephritis
Q39744383Belimumab efficacy is 'mild' but market potential still great†: anticipating us approval of the first lupus drug since 1957.
Q56907327Belimumab en el lupus eritematoso sistémico: una guía para su uso en la práctica diaria
Q95314636Belimumab for refractory manifestations of cutaneous lupus: a multicenter, retrospective observational study of 16 patients
Q84388543Belimumab for systemic lupus erythematosus
Q24201547Belimumab for systemic lupus erythematosus
Q28289098Belimumab for systemic lupus erythematosus
Q95516530Belimumab for systemic lupus erythematosus
Q46364779Belimumab for systemic lupus erythematosus: a practice-based view
Q48121915Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial
Q89241712Belimumab for the Treatment of Systemic Lupus Erythematosus (Sle) In Greece: A Cost-Effectiveness and Cost-Utility Analysis
Q38014539Belimumab for the management of systemic lupus erythematosus
Q89282338Belimumab for the treatment of corticosteroid-dependent systemic lupus erythematosus: from clinical trials to real-life experience after 1 year of use in 48 Brazilian patients
Q50933068Belimumab for the treatment of recalcitrant cutaneous lupus.
Q86088602Belimumab for the treatment of refractory systemic lupus erythematosus: real-life experience in the first year of use in 18 Italian patients
Q34455827Belimumab for the treatment of systemic lupus erythematosus
Q102319654Belimumab in Lupus Nephritis: New Trial Results Arrive During an Exciting Time for Therapeutics
Q37268312Belimumab in Systemic Lupus Erythematosus
Q92147284Belimumab in kidney transplantation
Q95409371Belimumab in kidney transplantation
Q92147291Belimumab in kidney transplantation - Authors' reply
Q89129026Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial
Q100465177Belimumab in lupus nephritis
Q33437342Belimumab in primary antiphospholipid syndrome
Q92307444Belimumab in refractory organizing pneumonia associated with systemic lupus erythematosus: a case report
Q26778277Belimumab in systemic lupus erythematosus
Q37698526Belimumab in systemic lupus erythematosus (SLE): evidence-to-date and clinical usefulness
Q87218028Belimumab in systemic lupus erythematosus -- what can be learned from longterm observational studies?
Q88100363Belimumab in systemic lupus erythematosus: Experience in clinical practice settings in a regional hospital
Q26796486Belimumab in systemic lupus erythematosus: a perspective review
Q36443781Belimumab in systemic lupus erythematosus: an update for clinicians
Q38810737Belimumab in the management of systemic lupus erythematosus - an update
Q101165735Belimumab in the treatment of Portuguese Systemic Lupus Erythematosus patients: a real-life multicenter study
Q36094045Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response
Q47815135Belimumab in the treatment of systemic lupus erythematous: An evidence based review of its place in therapy
Q97639512Belimumab is Able to Induce a Significant Improvement of Joint Activity Status in Patients Diagnosed with Systemic Lupus Erythematosus: Results From a 12-Month Longitudinal Study
Q97529168Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis
Q38005641Belimumab is approved by the FDA: what more do we need to know to optimize decision making?
Q89460143Belimumab may decrease flare rate and allow glucocorticoid withdrawal in lupus nephritis (including dialysis and transplanted patient)
Q87579928Belimumab may not prevent lupus nephritis in serologically active patients with ongoing non-renal disease activity
Q58760729Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients
Q91031158Belimumab reduces antiphospholipid antibodies in SLE patients independently of hydroxychloroquine treatment
Q96339082Belimumab reduces antiphospholipid antibodies in primary triple-positive antiphospholipid syndrome
Q35954719Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus
Q91286268Belimumab restores Treg/Th17 balance in patients with refractory systemic lupus erythematosus
Q91361736Belimumab slows organ damage progression
Q38097328Belimumab therapy in systemic lupus erythematosus
Q92496705Belimumab treatment in rhupus: A case report with severe skin involvement
Q33695128Belimumab use, clinical outcomes and glucocorticoid reduction in patients with systemic lupus erythematosus receiving belimumab in clinical practice settings: results from the OBSErve Canada Study
Q37876752Belimumab, a BLyS-specific inhibitor for the treatment of systemic lupus erythematosus
Q98513236Belimumab, a useful alternative therapy in systemic lupus erythematosus serositis
Q94707047Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases
Q49355618Belimumab: A Review in Systemic Lupus Erythematosus
Q38781470Belimumab: First targeted biological treatment for systemic lupus erythematosus
Q37809939Belimumab: a BLyS-specific inhibitor for systemic lupus erythematosus
Q37963178Belimumab: a BLyS-specific inhibitor for the treatment of systemic lupus erythematosus
Q83687622Belimumab: a guide to its use in systemic lupus erythematosus
Q28676968Belimumab: a technological advance for systemic lupus erythematosus patients? Report of a systematic review and meta-analysis
Q81217517Belimumab: anti-BLyS human monoclonal antibody, anti-BLyS monoclonal antibody, BmAb, human monoclonal antibody to B-lymphocyte stimulator
Q84323277Belimumab: anti-BLyS monoclonal antibody; Benlysta; BmAb; LymphoStat-B
Q37964706Belimumab: in systemic lupus erythematosus
Q34215264Belimumab: review of use in systemic lupus erythematosus
Q38084687Belimumab: targeted therapy for lupus.
Q39816043Bioavailability, Pharmacokinetics, and Safety of Belimumab Administered Subcutaneously in Healthy Subjects
Q100303794Biologic Sequencing in Systemic Lupus Erythematosus: After Secondary Non-response to Rituximab, Switching to Humanised Anti-CD20 Agent Is More Effective Than Belimumab
Q36993242Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus
Q38006643Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development?
Q38095862Breaking the ice in systemic lupus erythematosus: belimumab, a promising new therapy
Q91866358Budget Impact Analysis Of Subcutaneous Belimumab In Patients With Systemic Lupus Erythematosus In Spain
Q53752806Budget Impact Analysis of Belimumab In the Treatment of Patients With Systemic Lupus Erythematosus In Russian Federation.
Q98207784CALIBRATE: A Phase 2 Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis
Q49087015Case report: successful treatment of membranous lupus nephritis with belimumab in an African female immigrant
Q82732869Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects
Q96346733Clinical Efficacy of Routinely Administered Belimumab on Proteinuria and Neuropsychiatric Lupus
Q92249194Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland
Q47946068Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. Results of a large, multicentric, nationwide study
Q46792375Clinical response to belimumab in academic clinical practices
Q34478853Clinical, laboratory and health-related quality of life correlates of Systemic Lupus Erythematosus Responder Index response: a post hoc analysis of the phase 3 belimumab trials
Q88758022Comment on: New onset of lupus nephritis in two patients with SLE shortly after initiation of treatment with belimumab
Q100533241Comparative analysis of long-term organ damage in patients with systemic lupus erythematosus using belimumab versus standard therapy: a post hoc longitudinal study
Q88259378Comparative efficacy and safety of intravenous or subcutaneous belimumab in combination with standard therapy in patients with active systemic lupus erythematosus: a Bayesian network meta-analysis of randomized controlled trials
Q39855585Comparison of intravenous and subcutaneous exposure supporting dose selection of subcutaneous belimumab systemic lupus erythematosus Phase 3 program
Q83107271Connective tissue diseases: Belimumab for systemic lupus erythematosus: breaking through?
Q58709711Correction to: Effectiveness, Tolerability, and Safety of Belimumab in Patients with Refractory SLE: a Review of Observational Clinical-Practice-Based Studies
Q104572682Corticosteroid dosing and opioid use are high in patients with SLE and remain elevated after belimumab initiation: a retrospective claims database analysis
Q89241688Cost-Effectiveness Analysis of Belimumab In the Treatment of Adult Systemic Lupus Erythematosus (Sle) Patients With Positive Biomarkers In Spain
Q37456307Cumulative Corticosteroid Dose Over Fifty-Two Weeks in Patients With Systemic Lupus Erythematosus: Pooled Analyses From the Phase III Belimumab Trials
Q34960458Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents
Q104505750De novo lupus nephritis during treatment with belimumab
Q51929640Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator.
Q45237648Disease control and safety of belimumab plus standard therapy over 7 years in patients with systemic lupus erythematosus
Q91801674Early disease and low baseline damage predict response to belimumab in patients with systemic lupus erythematosus
Q93054164Effect of belimumab on proteinuria and anti-phospholipase A2 receptor autoantibody in primary membranous nephropathy
Q50950431Effect of belimumab on vaccine antigen antibodies to influenza, pneumococcal, and tetanus vaccines in patients with systemic lupus erythematosus in the BLISS-76 trial.
Q91233537Effect of belimumab treatment on antiphospholipid antibody levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus
Q46769274Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE.
Q33803763Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study
Q91542323Effectiveness and safety of belimumab in patients with systemic lupus erythematosus in a real-world setting
Q87984753Effectiveness, Tolerability, and Safety of Belimumab in Patients with Refractory SLE: a Review of Observational Clinical-Practice-Based Studies
Q51655536Effects of Belimumab on Flare Rate and Expected Damage Progression in Patients With Active Systemic Lupus Erythematosus.
Q36302240Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials
Q94597729Efficacity of a sequential treatment by anti-CD 20 monoclonal antibody and belimumab in type II cryoglobulinaemia associated with primary Sjögren syndrome refractory to rituximab alone
Q38791770Efficacy and Safety of Belimumab Plus Standard Therapy in Patients With Systemic Lupus Erythematosus: A Meta-analysis
Q91151840Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Study
Q88405056Efficacy and Safety of Subcutaneous Belimumab in Anti-Double-Stranded DNA-Positive, Hypocomplementemic Patients With Systemic Lupus Erythematosus
Q33698040Efficacy and Safety of Subcutaneous Belimumab in Systemic Lupus Erythematosus: A Fifty-Two-Week Randomized, Double-Blind, Placebo-Controlled Study
Q34369628Efficacy and safety data of belimumab in patients with systemic lupus erythematosus
Q41514433Efficacy and safety of belimumab given for 12 months in primary Sjögren's syndrome: the BELISS open-label phase II study
Q28304807Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
Q38453674Efficacy and safety of belimumab in patients with rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled, dose-ranging Study
Q39292745Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study
Q88787500Efficacy and safety of intravenous belimumab in Japanese patients with systemic lupus erythematosus: A subgroup analysis of a phase 3 randomized placebo-controlled trial
Q57807541Efficacy of Belimumab for active lupus nephritis in a young Hispanic woman intolerant to standard treatment: a case report
Q95830647Efficacy of Belimumab in Primary Sjögren's Syndrome: A Systematic Review
Q99345897Efficacy of a sequential treatment by belimumab in monogenic systemic lupus erythematosus
Q50929875Efficacy of belimumab and targeting of rheumatoid factor-positive B-cell expansion in Sjögren's syndrome: follow-up after the end of the phase II open-label BELISS study.
Q95375348Efficacy of belimumab for the long-term maintenance therapy of thrombocytopenia in systemic lupus erythematosus
Q38986342Efficacy of belimumab on renal outcomes in patients with systemic lupus erythematosus: A systematic review
Q35568194Efficacy of novel monoclonal antibody belimumab in the treatment of lupus nephritis
Q35761089Efficacy, pharmacokinetic and pharmacodynamic profile of belimumab for systemic lupus erythematosus
Q98575505Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial
Q36672666Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab
Q90891574Established organ damage reduces belimumab efficacy in systemic lupus erythematosus
Q89241748Evaluation of Use of Belimumab In Clinical Practice Settings (Observe Study) In Spain: Health Resource Utilization and Labour Absenteeism
Q95537033Evaluation of a novel autoinjector for subcutaneous self-administration of belimumab in systemic lupus erythematosus
Q98462463Evaluation of belimumab treatment in patients with systemic lupus erythematosus in a clinical practice setting: Results from a 24-month OBSErve study in Argentina
Q96639346Exposure to Belimumab in the First Trimester of Pregnancy in a Young Woman With Systemic Lupus Erythematosus
Q89182146Favorable pregnancy outcome in a patient with systemic lupus erythematosus treated with belimumab: A confirmation report
Q30490276First Real-World Insights into Belimumab Use and Outcomes in Routine Clinical Care of Systemic Lupus Erythematosus in Germany: Results from the OBSErve Germany Study.
Q28183674Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator
Q34114253Health technology assessment of belimumab: a new monoclonal antibody for the treatment of systemic lupus erythematosus
Q60913872Impact of belimumab on patient-reported outcomes in systemic lupus erythematosus: review of clinical studies
Q37384403Impact of concomitant medication use on belimumab efficacy and safety in patients with systemic lupus erythematosus
Q37715948Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials
Q91554193Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus
Q94472394Influenza vaccine in patients on biological therapy; also with belimumab
Q59791466Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab
Q48504730Long-Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus: A Continuation of a Seventy-Six-Week Phase III Parent Study in the United States
Q96766194Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results
Q57461365Long-term impact of belimumab on health-related quality of life and fatigue in patients with systemic lupus erythematosus: 6 years of treatment
Q37121787Long-term organ damage accrual and safety in patients with SLE treated with belimumab plus standard of care
Q91856866Long-term safety and limited organ damage in patients with systemic lupus erythematosus treated with belimumab: a Phase III study extension
Q42652135Long-term safety profile of belimumab plus standard therapy in patients with systemic lupus erythematosus
Q51738271Low disease activity-irrespective of serologic status at baseline-associated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: A real-life observational study.
Q36027561Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjögren's syndrome: results of the BELISS study
Q91209271Lupus Low Disease Activity State (LLDAS) discriminates responders in the BLISS-52 and BLISS-76 phase III trials of belimumab in systemic lupus erythematosus
Q50118147Lupus erythematosus treatment with belimumab in daily practice: Retrospective study of 15 patients
Q98472136Lupus low disease activity (SLE) in patients treated with belimumab: a single-center real-life experience (2016-2019)
Q98179037Lupus-associated protein losing enteropathy (LUPLE) complicated by a hypercoagulable state and successfully treated with belimumab
Q88204200Lymphocyte changes and vaccination response in a child exposed to belimumab during pregnancy
Q96952828Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab
Q35566828Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis.
Q99725012Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia
Q84068974New drugs. Azilsartan medoxomil, belimumab, and lurasidone hydrochloride
Q57789397OP0302 Significant reductions of pathogenic autoantibodies by synergetic rituximab and belimumab treatment effectively inhibits neutrophil extracellular traps in severe, refractory sle - the synbiose study
Q64229203Organ damage in patients treated with belimumab versus standard of care: a propensity score-matched comparative analysis
Q92745817Organ system improvements in Japanese patients with systemic lupus erythematosus treated with belimumab: A subgroup analysis from a phase 3 randomized placebo-controlled trial
Q47624115Patient Evaluation of Satisfaction and Outcomes with an Autoinjector for Self-Administration of Subcutaneous Belimumab in Patients with Systemic Lupus Erythematosus
Q91736978Patient Satisfaction And Disease Control In Patients With Systemic Lupus Erythematosus Is Not Affected By Switching From Intravenous Belimumab To Subcutaneous Injections
Q91782881Pharmacogenetic analysis of belimumab fails to identify robust genetic predictors of efficacy in lupus
Q103017434Pharmacokinetics of Belimumab in Children With Systemic Lupus Erythematosus
Q92742184Pharmacokinetics, Pharmacodynamics and Safety of Belimumab in Chinese Patients with Systemic Lupus Erythematosus: A Phase I, Open-Label Study
Q64069128Phase III, multicentre, randomised, double-blind, placebo-controlled, 104-week study of subcutaneous belimumab administered in combination with rituximab in adults with systemic lupus erythematosus (SLE): BLISS-BELIEVE study protocol
Q48010137Population Pharmacokinetic and Pharmacodynamic Analysis of Belimumab Administered Subcutaneously in Healthy Volunteers and Patients with Systemic Lupus Erythematosus
Q43529181Population pharmacokinetics of belimumab following intravenous administration in patients with systemic lupus erythematosus
Q38230701Post-marketing experiences with belimumab in the treatment of SLE patients
Q92485957Predictors of low disease activity and clinical remission following belimumab treatment in systemic lupus erythematosus
Q48302795Progressive multifocal leukoencephalopathy associated with belimumab in a patient with systemic lupus erythematosus
Q55267717Randomized study of adjunctive belimumab in participants with generalized myasthenia gravis.
Q39953054Real life experience on the effect of Belimumab in patients with active systemic lupus
Q102147270Real-World Effectiveness of Belimumab in the Treatment of Systemic Lupus Erythematosus: Pooled Analysis of Multi-Country Data from the OBSErve Studies
Q93271975Real-world treatment patterns, healthcare resource utilisation and costs in patients with systemic lupus erythematosus treated with belimumab: a retrospective analysis of claims data in the USA
Q56907345Recomendaciones sobre el uso de belimumab en el lupus eritematoso sistémico. Guía de Práctica Clínica GEAS-SEMI
Q45122982Recommendation for use of belimumab for systemic lupus erythematosus
Q85275853Refractory subacute cutaneous lupus erythematous responding to a single course of belimumab: a new anti-BLyS human monoclonal antibody
Q37337375Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects
Q36472640Response to belimumab among patients with systemic lupus erythematosus in clinical practice settings: 24-month results from the OBSErve study in the USA.
Q91720949Response to: 'Achieving lupus low disease activity and remission states under belimumab in refractory systemic lupuserythematosus: time and organ involvement matter' by Sbeih et al
Q102069135Rituximab Followed by Belimumab Controls Severe Lupus Nephritis and Bullous Pemphigoid in Systemic Lupus Erythematosus Refractory to Several Combination Therapies
Q103041670Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study
Q95552844Rituximab-refractory lupus nephritis successfully treated with belimumab
Q57789401SAT0258 Synergetic b-cell immunomodulation with rituximab and belimumab is clinically effective in severe and refractory systemic lupus erythematosus – the synbiose proof-of-concept study
Q91640209Safety and Efficacy of Belimumab Plus Standard Therapy for Up to Thirteen Years in Patients With Systemic Lupus Erythematosus
Q37272264Safety and Efficacy of Belimumab to Treat Systemic Lupus Erythematosus in Academic Clinical Practices
Q97546502Safety and efficacy of belimumab after B cell depletion therapy in systemic LUPUS erythematosus (BEAT-LUPUS) trial: statistical analysis plan
Q97652337Safety and efficacy of intravenous belimumab in children with systemic lupus erythematosus: results from a randomised, placebo-controlled trial
Q30580226Safety profile of belimumab: pooled data from placebo-controlled phase 2 and 3 studies in patients with systemic lupus erythematosus
Q37077223Safety, tolerability, pharmacokinetics and pharmacodynamics of belimumab in Japanese patients with mild-to-moderate systemic lupus erythematosus
Q95358443Sequential therapy with belimumab followed by rituximab in Sjögren's syndrome associated with B-cell lymphoproliferation and overexpression of BAFF: evidence for long-term efficacy
Q39143034Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus
Q89351208Smoking reduces the efficacy of belimumab in mucocutaneous lupus
Q38605480Subcutaneous and intravenous belimumab in the treatment of systemic lupus erythematosus: a review of data on subcutaneous and intravenous administration
Q90935648Subcutaneous belimumab in the treatment of systemic lupus erythematosus
Q59789656Subcutaneous formulation of belimumab in treatment of systemic lupus erythematosus: a critical review with focus on safety and satisfaction
Q51164426Successful application of belimumab in two patients with systemic lupus erythematosus experiencing a flare during tocilizumab treatment.
Q52658159Successful sequential therapy with rituximab and belimumab in patients with active systemic lupus erythematosus: a case series.
Q44050390Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman
Q89309517Successful treatment of refractory lupus nephritis by the sequential use of rituximab and belimumab
Q51152275Successful treatment of refractory systemic lupus erythematosus using proteasome inhibitor bortezomib followed by belimumab: description of two cases.
Q92308423Successful treatment of systemic lupus erythematosus pleuropericarditis with belimumab
Q104582839Systematic review of safety and efficacy of belimumab in treating immune-mediated disorders
Q38948425Systemic lupus erythematosus exacerbation following cessation of belimumab treatment
Q51104713Systemic lupus erythematous exacerbation following cessation of belimumab treatment: comments on the article by Furer et al.
Q90585211The Impact of Belimumab and Rituximab on Health-Related Quality of Life in Patients With Systemic Lupus Erythematosus
Q52595520The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus.
Q35691272The discovery and development of belimumab: the anti-BLyS-lupus connection
Q42622871The pharmacokinetics and safety profiles of belimumab after single subcutaneous and intravenous doses in healthy Japanese volunteers
Q40232762The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales
Q40183925The potential overlapping populations for treatment with belimumab and rituximab using current NHS England and National Institute for Health and Care Excellence Guidelines in England and Wales.
Q94517994The role of baseline BLyS levels and type 1 interferon-inducible gene signature status in determining belimumab response in systemic lupus erythematosus: a post hoc meta-analysis
Q90969407The safety of belimumab for the treatment of systemic lupus erythematosus
Q40246614Treatment with belimumab in systemic lupus erythematosus does not impair antibody response to 13-valent pneumococcal conjugate vaccine
Q50748403Treatment with belimumab restores B cell subsets and their expression of B cell activating factor receptor in patients with primary Sjogren's syndrome.
Q99554983Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis
Q50851171Type I interferon signature may influence the effect of belimumab on immunoglobulin levels, including rheumatoid factor in Sjögren's syndrome.
Q38258871Update on belimumab for the management of systemic lupus erythematosus
Q38344444Use of B lymphocyte stimulator inhibitor belimumab may be associated with a decrease in the serum concentration of epidermal growth factor in patients with primary Sjögren's syndrome
Q50231398Use of Belimumab throughout 2 Consecutive Pregnancies in a Patient with Systemic Lupus Erythematosus.
Q38227435Use of belimumab throughout pregnancy to treat active systemic lupus erythematosus: a case report
Q54113599When to use belimumab in SLE.
Q95809611[Belimumab in systemic lupus erythematosus: a guide for its use in the daily practice]
Q53493843[Cost-effectiveness analysis of Belimumab in patients with systemic lupus erythematosus in Spain].
Q80644952[Human monoclonal antibody to B-lymphocyte stimulator (belimumab) and humanized anti-LFA-1 monoclonal antibodies (efalizumab)]
Q92929406[Resistant and progressive cutaneous lupus erythematosus treated with belimumab: A retrospective monocentric study]

Q409346TNF superfamily member 13bphysically interacts withP129
Q1621830lupus nephritisdrug or therapy used for treatmentP2176
Q29004890Benlystahas active ingredientP3781

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