Abstract is: KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). It is called KRAS because it was first identified as a viral oncogene in the Kirsten RAt Sarcoma virus. The oncogene identified was derived from a cellular genome, so KRAS, when found in a cellular genome, is called a proto-oncogene. The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. To transmit signals, it must be turned on by attaching (binding) to a molecule of GTP. The K-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the nucleus. The gene product of KRAS, the K-Ras protein, was first found as a p21 GTPase. Like other members of the ras subfamily of GTPases, the K-Ras protein is an early player in many signal transduction pathways. K-Ras is usually tethered to cell membranes because of the presence of an isoprene group on its C-terminus. There are two protein products of the KRAS gene in mammalian cells that result from the use of alternative exon 4 (exon 4A and 4B respectively): K-Ras4A and K-Ras4B. These proteins have different structures in their C-terminal region and use different mechanisms to localize to cellular membranes, including the plasma membrane.
P11277 | CIViC gene ID | 30 |
P594 | Ensembl gene ID | ENSG00000133703 |
P704 | Ensembl transcript ID | ENST00000256078 |
ENST00000311936 | ||
ENST00000556131 | ||
ENST00000557334 | ||
ENST00000685328 | ||
ENST00000686877 | ||
ENST00000686969 | ||
ENST00000687356 | ||
ENST00000688228 | ||
ENST00000688940 | ||
ENST00000690406 | ||
ENST00000690804 | ||
ENST00000692768 | ||
ENST00000693229 | ||
P351 | Entrez Gene ID | 3845 |
P2888 | exact match | http://identifiers.org/ncbigene/3845 |
P646 | Freebase ID | /m/027wcx5 |
P353 | HGNC gene symbol | KRAS |
P354 | HGNC ID | 6407 |
P593 | HomoloGene ID | 37990 |
P6366 | Microsoft Academic ID | 2781187634 |
P492 | OMIM ID | 190070 |
190070 | ||
P10283 | OpenAlex ID | C2781187634 |
P639 | RefSeq RNA ID | NM_001369786 |
NM_001369787 | ||
NM_004985 | ||
NM_033360 | ||
XM_047428826 | ||
P2892 | UMLS CUI | C1537502 |
P1057 | chromosome | human chromosome 12 | Q847102 |
P4196 | cytogenetic location | 12p12.1 | |
P688 | encodes | KRAS proto-oncogene, GTPase | Q4042017 |
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b | Q21149631 | ||
P5572 | expressed in | trigeminal ganglion | Q776972 |
nipple | Q188641 | ||
pylorus | Q290248 | ||
cardia | Q1542842 | ||
endothelial cell | Q11394395 | ||
oral cavity | Q27042858 | ||
jejunal mucosa | Q30015772 | ||
tail of epididymis | Q66509454 | ||
mucosa of sigmoid colon | Q66511227 | ||
mucosa of pharynx | Q66544773 | ||
P703 | found in taxon | Homo sapiens | Q15978631 |
P2293 | genetic association | adenocarcinoma of the lung | Q843799 |
acute myeloid leukemia | Q264118 | ||
juvenile myelomonocytic leukemia | Q2578247 | ||
non-small-cell lung carcinoma | Q3658562 | ||
large intestine adenocarcinoma | Q18553556 | ||
Noonan syndrome 3 | Q26492791 | ||
P645 | genomic end | 25403870 | |
25250936 | |||
P644 | genomic start | 25205246 | |
25357723 | |||
P138 | named after | Werner H. Kirsten | Q91026610 |
P684 | ortholog | Kras | Q18251906 |
Kras | Q24408160 | ||
let-60 | Q29702110 | ||
Ras85D | Q29711768 | ||
kras | Q29783423 | ||
P2548 | strand orientation | reverse strand | Q22809711 |
FileName: PBB GE KRAS 204009 s at fs.png
Description: Gene expression pattern of the KRAS gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE KRAS 204010 s at fs.png
Description: Gene expression pattern of the KRAS gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
FileName: PBB GE KRAS 214352 s at fs.png
Description: Gene expression pattern of the KRAS gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
Q27593175 | hsa-let-7a-5p |
Q27594354 | hsa-let-7c-3p |
Q27594496 | hsa-let-7g-5p |
Q27594337 | hsa-miR-124-5p |
Q27595172 | hsa-miR-126-3p |
Q27593468 | hsa-miR-134-5p |
Q27594720 | hsa-miR-143-3p |
Q27593795 | hsa-miR-152-3p |
Q27594358 | hsa-miR-155-5p |
Q27593305 | hsa-miR-16-5p |
Q27592886 | hsa-miR-181a-5p |
Q27593968 | hsa-miR-181c-5p |
Q27594930 | hsa-miR-183-5p |
Q27593326 | hsa-miR-18a-3p |
Q27593751 | hsa-miR-193a-3p |
Q27593625 | hsa-miR-193b-3p |
Q27115065 | hsa-miR-200b-3p |
Q27593187 | hsa-miR-200c-3p |
Q27595098 | hsa-miR-204-3p |
Q27594811 | hsa-miR-206 |
Q27594161 | hsa-miR-216b-5p |
Q27594158 | hsa-miR-217 |
Q27595338 | hsa-miR-224-5p |
Q27593964 | hsa-miR-27a-3p |
Q27594817 | hsa-miR-30a-3p |
Q27595039 | hsa-miR-30d-3p |
Q27592770 | hsa-miR-30e-3p |
Q27594141 | hsa-miR-3125 |
Q27594989 | hsa-miR-3148 |
Q27594292 | hsa-miR-3192-5p |
Q27593142 | hsa-miR-326 |
Q27594002 | hsa-miR-330-5p |
Q27594749 | hsa-miR-340-5p |
Q27594234 | hsa-miR-3606-3p |
Q27593626 | hsa-miR-365a-3p |
Q27592937 | hsa-miR-3916 |
Q27592707 | hsa-miR-429 |
Q27593712 | hsa-miR-4314 |
Q27595253 | hsa-miR-4328 |
Q27593408 | hsa-miR-433-3p |
Q27595340 | hsa-miR-452-5p |
Q27594776 | hsa-miR-4646-5p |
Q27595195 | hsa-miR-4666b |
Q27593197 | hsa-miR-4698 |
Q27593455 | hsa-miR-487b-3p |
Q27593779 | hsa-miR-5010-3p |
Q27595318 | hsa-miR-513a-3p |
Q27595314 | hsa-miR-513c-3p |
Q27595334 | hsa-miR-514a-5p |
Q27594227 | hsa-miR-548ae-3p |
Q27594610 | hsa-miR-548ah-3p |
Q27594831 | hsa-miR-548aj-3p |
Q27595189 | hsa-miR-548am-3p |
Q27594566 | hsa-miR-548aq-3p |
Q27594398 | hsa-miR-548j-3p |
Q27593317 | hsa-miR-548x-3p |
Q27593078 | hsa-miR-5582-3p |
Q27593259 | hsa-miR-619-5p |
Q27593322 | hsa-miR-622 |
Q27594004 | hsa-miR-642a-5p |
Q27594007 | hsa-miR-642b-5p |
Q27593637 | hsa-miR-6506-5p |
Q27594947 | hsa-miR-671-5p |
Q27593167 | hsa-miR-6716-5p |
Q27115052 | hsa-miR-6859-5p |
Q27593770 | hsa-miR-6866-5p |
Q27595080 | hsa-miR-873-5p |
Q27594768 | hsa-miR-877-5p |
Q27595309 | hsa-miR-892b |
Q27594928 | hsa-miR-96-5p |
Q26492791 | Noonan syndrome 3 |
Q18217139 | RAS-associated autoimmune leukoproliferative disorder |
Q264118 | acute myeloid leukemia |
Q843799 | adenocarcinoma of the lung |
Q1097490 | cardiofaciocutaneous syndrome |
Q2578247 | juvenile myelomonocytic leukemia |
Q18553556 | large intestine adenocarcinoma |
Q3658562 | non-small-cell lung carcinoma |
Q107522015 | KRAS A11_G12insGA |
Q88412581 | KRAS A146 |
Q29938360 | KRAS A146P |
Q29938362 | KRAS A146T |
Q28371275 | KRAS A146V |
Q32964894 | KRAS A59T |
Q28445165 | KRAS Amplification |
Q27908371 | KRAS Exon 2 Mutation |
Q107522014 | KRAS G10_A11insG |
Q27917107 | KRAS G12 |
Q28371010 | KRAS G12/G13 |
Q28371066 | KRAS G12A |
Q28371011 | KRAS G12C |
Q28371012 | KRAS G12D |
Q28371486 | KRAS G12R |
Q29938370 | KRAS G12S |
Q28371388 | KRAS G12V |
Q28371013 | KRAS G13 |
Q32948338 | KRAS G13C |
Q28371015 | KRAS G13D |
Q32964797 | KRAS G13R |
Q32964802 | KRAS G13S |
Q32964984 | KRAS G13V |
Q32948857 | KRAS K117N |
Q28445037 | KRAS Mutation |
Q28381659 | KRAS Q22* |
Q28531489 | KRAS Q61 |
Q29938644 | KRAS Q61E |
Q29938645 | KRAS Q61FS |
Q29938363 | KRAS Q61H |
Q29938368 | KRAS Q61K |
Q29938364 | KRAS Q61L |
Q29938641 | KRAS Q61P |
Q29938366 | KRAS Q61R |
Q106942558 | KRAS R164Q |
Q28420832 | KRAS RS61764370 |
Q99542858 | KRAS Wildtype |
Q109861301 | Alzheimer's disease |
Q29892262 | Alzheimer's disease and miRNA effects |
Q30225516 | Aryl hydrocarbon receptor Netpath |
Q30225415 | BDNF-TrkB signaling |
Q30230812 | Bladder cancer |
Q54991093 | Breast cancer pathway |
Q30225529 | Chemokine signaling pathway |
Q50400050 | Chromosomal and microsatellite instability in colorectal cancer |
Q30231006 | DNA damage response (only ATM dependent) |
Q30225560 | EGF/EGFR signaling pathway |
Q102733920 | EGFR tyrosine kinase inhibitor resistance |
Q63153177 | Envelope proteins and their potential roles in EDMD physiopathology |
Q54989421 | Epithelial to mesenchymal transition in colorectal cancer |
Q30230897 | ErbB signaling pathway |
Q30230820 | Extracellular vesicle-mediated signaling in recipient cells |
Q30230865 | Focal adhesion: PI3K-Akt-mTOR-signaling pathway |
Q109861037 | Fragile X syndrome |
Q30230927 | G protein signaling pathways |
Q72082709 | Gastrin signaling pathway |
Q29892275 | Glioblastoma signaling pathways |
Q75747823 | Head and neck squamous cell carcinoma |
Q67131122 | Hepatitis B infection |
Q62059966 | Hippo-Merlin signaling dysregulation |
Q30225358 | IL-5 signaling pathway |
Q54990016 | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
Q30231034 | Integrated breast cancer pathway |
Q102732586 | Kisspeptin/kisspeptin receptor system in the ovary |
Q30225554 | MAPK cascade |
Q109860945 | MAPK pathway in congenital thyroid cancer |
Q29891990 | MAPK signaling pathway |
Q50400632 | MET in type 1 papillary renal cell carcinoma |
Q78271851 | Melanoma |
Q59693704 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
Q54989956 | Non-small cell lung cancer |
Q30225494 | Oncostatin M signaling pathway |
Q30225421 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
Q50400941 | PI3K-Akt signaling pathway |
Q54990258 | Pancreatic adenocarcinoma pathway |
Q30225450 | RAC1/PAK1/p38/MMP2 pathway |
Q30230784 | RalA downstream regulated genes |
Q54989898 | Ras signaling |
Q30225571 | Regulation of actin cytoskeleton |
Q75740366 | Relationship between inflammation, COX-2 and EGFR |
Q30230906 | Serotonin receptor 2 and ELK-SRF/GATA4 signaling |
Q62059922 | Synaptic signaling pathways associated with autism spectrum disorder |
Q30225482 | TNF-alpha signaling pathway |
Q61996231 | Thermogenesis |
Q44013044 | endometrial cancer |
Q44017754 | miRNA regulation of prostate cancer signaling pathways |
Q49243022 | Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output | main subject | P921 |
Arabic (ar / Q13955) | كيراس | wikipedia |
Egyptian Arabic (arz / Q29919) | كيراس | wikipedia |
KRAS | wikipedia | |
cy | KRAS | wikipedia |
KRAS | wikipedia | |
Persian (fa / Q9168) | KRAS | wikipedia |
KRAS | wikipedia | |
KRAS | wikipedia | |
KRAS | wikipedia | |
KRAS | wikipedia | |
KRAS | wikipedia | |
KRAS | wikipedia |
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