The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol

scientific article published in 2010

The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...512527S
P356DOI10.1371/JOURNAL.PONE.0012527
P932PMC publication ID2931709
P698PubMed publication ID20824145
P5875ResearchGate publication ID46170856

P50authorPia SteenslandQ37376678
P2093author name stringSelena E Bartlett
Jeffrey A Simms
Joan Holgate
Carsten K Nielsen
Jade J Bito-Onon
P2860cites workEvidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intakeQ24651508
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Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in ratsQ33893401
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brainQ33956242
Anti-emetic activity of the novel nonpeptide tachykinin NK1 receptor antagonist ezlopitant (CJ-11,974) against acute and delayed cisplatin-induced emesis in the ferretQ34153806
Food reward: brain substrates of wanting and likingQ34378340
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A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking ratsQ34822245
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Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitryQ35069558
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A Sucrose-Based Maintenance Diet Increases Sensitivity to Appetite Suppressant Effects of NaloxoneQ52192341
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Pharmacokinetics of ezlopitant, a novel non-peptidic neurokinin-1 receptor antagonist in preclinical species and metabolite kinetics of the pharmacologically active metabolitesQ74199918
Environmental Contributions to the Obesity EpidemicQ74594316
Randomized phase II study of the neurokinin 1 receptor antagonist CJ-11,974 in the control of cisplatin-induced emesisQ78160867
Nucleus accumbens AGS3 expression drives ethanol seeking through G betagammaQ36858644
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Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in ratsQ38326196
Incubation of sucrose craving: effects of reduced training and sucrose pre-loadingQ40876416
Food Cravings, Endogenous Opioid Peptides, and Food Intake: A ReviewQ41703427
Antidepressant-like effects of neurokinin receptor antagonists in the forced swim test in the rat.Q41950122
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variationQ42481345
Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat.Q42487651
Endogenous opioids and addiction to alcohol and other drugs of abuseQ43065501
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans ratsQ43146230
Voluminous sucrose consumption in female rats: increased "nippiness" during periods of sucrose removal and possible oestrus periodicityQ43920552
A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in ratsQ43921764
Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart AssociationQ44075655
Ventral tegmental lesions reduce overconsumption of normally preferred taste fluid in ratsQ44111411
Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptorsQ44278081
A dopamine-mu1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse.Q44350045
The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisstQ44393136
Oral sucrose stimulation increases accumbens dopamine in the rat.Q44559097
Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse.Q44580796
A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamineQ44641400
Opiate-like effects of sugar on gene expression in reward areas of the rat brainQ44890065
Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J miceQ45218696
Sucrose intake enhances behavioral sensitization produced by cocaineQ45223106
Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effectQ46374014
Daily bingeing on sugar repeatedly releases dopamine in the accumbens shellQ46574961
Enkephalinergic afferents of the centromedial amygdala in the rat.Q48574704
Leptin attenuates acute food deprivation-induced relapse to heroin seeking.Q48691260
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e12527
P577publication date2010-01-01
P1433published inPLOS OneQ564954
P1476titleThe neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol
P478volume5

Reverse relations

cites work (P2860)
Q37656920A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption.
Q37397620Emerging targets for addiction neuropharmacology: From mechanisms to therapeutics
Q43195621Evaluation of guanfacine as a potential medication for alcohol use disorder in long-term drinking rats: behavioral and electrophysiological findings.
Q34782251Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome
Q27014840Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders
Q36394976Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats.
Q89752603Neurokinin receptors in drug and alcohol addiction
Q37886661New drug targets for the treatment of obesity.
Q36398095Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
Q41449163Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice
Q35332004Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.
Q36390400Stress-related neuropeptides and addictive behaviors: beyond the usual suspects
Q52307485Substance P in the anterior thalamic paraventricular nucleus: promotion of ethanol drinking in response to orexin from the hypothalamus
Q37593097Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease
Q37172269Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats
Q26785438The pharmacology of neurokinin receptors in addiction: prospects for therapy
Q37514878The α5 neuronal nicotinic acetylcholine receptor subunit plays an important role in the sedative effects of ethanol but does not modulate consumption in mice
Q50448931Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration

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