| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Estelle Sontag | |
| Jean-Marie Sontag | |||
| P2860 | cites work | Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. | Q54591455 |
| Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit | Q68244966 | ||
| Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex | Q74315843 | ||
| S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. | Q50974734 | ||
| Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. | Q51981069 | ||
| Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. | Q52206922 | ||
| S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. | Q52677310 | ||
| Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. | Q53265449 | ||
| Spatial control of protein phosphatase 2A (de)methylation. | Q53530037 | ||
| A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A | Q22009542 | ||
| Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue | Q22010935 | ||
| The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | Q24312201 | ||
| Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells | Q24338461 | ||
| Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Q24595802 | ||
| Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit | Q24598698 | ||
| A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain | Q24607382 | ||
| Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease | Q24627125 | ||
| Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet | Q24644293 | ||
| The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity | Q26824764 | ||
| PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1 | Q26830813 | ||
| Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling | Q27315944 | ||
| Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity | Q27642733 | ||
| Structural mechanism of demethylation and inactivation of protein phosphatase 2A | Q27650263 | ||
| Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation | Q27652517 | ||
| Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions | Q27930953 | ||
| Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits | Q28265452 | ||
| Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein | Q28344418 | ||
| An NMDA receptor signaling complex with protein phosphatase 2A | Q28568587 | ||
| Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations | Q28577828 | ||
| Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation | Q28638545 | ||
| Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities | Q28943531 | ||
| Tau and src family tyrosine kinases | Q30160372 | ||
| Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination | Q30432991 | ||
| Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease | Q30444790 | ||
| Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta | Q30473576 | ||
| Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation | Q30520621 | ||
| Age-specific epigenetic drift in late-onset Alzheimer's disease | Q33351991 | ||
| Molecular mechanisms of neurodegeneration in Alzheimer's disease | Q33871297 | ||
| PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus | Q33938971 | ||
| Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. | Q33952539 | ||
| Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models | Q34068459 | ||
| Protein phosphatase 2A: the Trojan Horse of cellular signaling | Q34189302 | ||
| Association between the MTHFR gene and Alzheimer's disease: a meta-analysis | Q34191574 | ||
| Phosphoprotein phosphatase activities in Alzheimer disease brain | Q34356873 | ||
| Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis | Q34379154 | ||
| Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling | Q34411340 | ||
| Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease | Q35083891 | ||
| Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? | Q35175404 | ||
| The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment | Q35588860 | ||
| Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit | Q35669844 | ||
| Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice | Q35791948 | ||
| The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. | Q35922428 | ||
| Homocysteine: overview of biochemistry, molecular biology, and role in disease processes | Q36208923 | ||
| A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle | Q36235418 | ||
| Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse | Q36698092 | ||
| The role of B vitamins in preventing and treating cognitive impairment and decline | Q36828684 | ||
| Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction | Q37019493 | ||
| PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). | Q37091364 | ||
| Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells | Q37189534 | ||
| Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology | Q37296372 | ||
| From promiscuity to precision: protein phosphatases get a makeover | Q37414833 | ||
| Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41. | Q37428610 | ||
| PR65A phosphorylation regulates PP2A complex signaling | Q37499214 | ||
| Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam | Q37519695 | ||
| B vitamins and the aging brain | Q37811078 | ||
| Post-translational modifications of tau protein: implications for Alzheimer's disease. | Q37826875 | ||
| One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? | Q37869578 | ||
| Folate, vitamin B₁₂, and S-adenosylmethionine | Q38093959 | ||
| Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes | Q38101982 | ||
| New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease. | Q38149943 | ||
| A gene expression profile of Alzheimer's disease | Q38293042 | ||
| Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. | Q39297592 | ||
| Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1. | Q39325433 | ||
| Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells | Q39636788 | ||
| B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A. | Q39739197 | ||
| Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation | Q39920851 | ||
| Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms | Q40145927 | ||
| Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules | Q40152410 | ||
| Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. | Q40158925 | ||
| Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites | Q41115192 | ||
| Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. | Q41147532 | ||
| Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain | Q41873844 | ||
| Protein phosphatase 2A is associated in an inactive state with microtubules through 2A1-specific interaction with tubulin | Q42158516 | ||
| Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons | Q42473195 | ||
| Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse | Q43664665 | ||
| Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease | Q43674700 | ||
| Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. | Q43687951 | ||
| Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. | Q43906989 | ||
| Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats | Q44154662 | ||
| Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls | Q44239000 | ||
| Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype. | Q44995624 | ||
| Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology | Q46041847 | ||
| PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. | Q46575385 | ||
| Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation | Q46785508 | ||
| Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels | Q46975024 | ||
| Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. | Q47730911 | ||
| I1PP2A and I2PP2A. Two potent protein phosphatase 2A-specific inhibitor proteins | Q47844649 | ||
| Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies | Q48125013 | ||
| Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus | Q48151986 | ||
| Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats | Q48317438 | ||
| Phosphorylation of tau, Abeta-formation, and apoptosis after in vivo inhibition of PP-1 and PP-2A. | Q48482683 | ||
| Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine | Q48485065 | ||
| The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation | Q48486318 | ||
| Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice | Q48597411 | ||
| Protein phosphatase inhibitors induce modification of synapse structure and tau hyperphosphorylation in cultured rat hippocampal neurons. | Q48697482 | ||
| Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. | Q50928336 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 16 | |
| P577 | publication date | 2014-01-01 | |
| P1433 | published in | Frontiers in Molecular Neuroscience | Q27721913 |
| P1476 | title | Protein phosphatase 2A dysfunction in Alzheimer's disease | |
| P478 | volume | 7 |
| Q38720656 | A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation |
| Q34363475 | A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype |
| Q34077890 | Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice |
| Q54722624 | Alzheimer's Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons. |
| Q39136356 | Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model. |
| Q47334563 | An Approach to Incorporate Multi-Enzyme Digestion into C-TAILS for C-Terminomics Studies |
| Q52594209 | An Overview on the Clinical Development of Tau-Based Therapeutics. |
| Q91841076 | Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation |
| Q58607655 | Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model |
| Q47552746 | Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum |
| Q34283467 | Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. |
| Q52319923 | Degradation or aggregation: the ramifications of post-translational modifications on tau. |
| Q37307494 | Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies |
| Q47279111 | Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid |
| Q64060653 | Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease |
| Q48114156 | Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells |
| Q40506203 | Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats. |
| Q57454966 | Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease |
| Q83231233 | Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons |
| Q33624894 | Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice |
| Q48389456 | Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons |
| Q35077291 | Fragile X mental retardation protein: from autism to neurodegenerative disease. |
| Q38659874 | Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology |
| Q38826441 | GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner |
| Q92659770 | In vitro Anti-cholinesterase and Anti-oxidant Activity of Three Standardised Polyherbal Products Used for Memory Enhancing in Ethnomedicine of South-East Nigeria |
| Q38542520 | Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System |
| Q52649855 | Integrative Computational Network Analysis Reveals Site-Specific Mediators of Inflammation in Alzheimer's Disease. |
| Q38263698 | Invited review: Drug development for tauopathies |
| Q50190181 | Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells. |
| Q99596103 | Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models |
| Q39387270 | Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease |
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| Q35755974 | Pathway Analysis Based on a Genome-Wide Association Study of Polycystic Ovary Syndrome |
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| Q26860395 | Physiological and pathological phosphorylation of tau by Cdk5 |
| Q39673659 | Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. |
| Q47252033 | Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease |
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| Q38700387 | Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition |
| Q92399660 | Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome |
| Q26864804 | Rodent models of neuroinflammation for Alzheimer's disease |
| Q38991133 | Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model. |
| Q38734515 | Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. |
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