Management of bleeding and coagulopathy following major trauma: an updated European guideline

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Management of bleeding and coagulopathy following major trauma: an updated European guideline is …
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P6179Dimensions Publication ID1046113313
P356DOI10.1186/CC12685
P3181OpenCitations bibliographic resource ID47722
P932PMC publication ID4056078
P698PubMed publication ID23601765
P5875ResearchGate publication ID236250473

P50authorEdmund NeugebauerQ1286682
Jean-Louis VincentQ3167023
Rolf RossaintQ59767472
Jacques DuranteauQ75512986
Daniela FilipescuQ50288400
P2093author name stringDonat R Spahn
Bertil Bouillon
Beverley J Hunt
Vladimir Cerny
Arthur Schultz
Enrique Fernández-Mondéjar
Giuseppe Nardi
Louis Riddez
Radko Komadina
Timothy J Coats
Yves Ozier
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Hemostatic resuscitation with plasma and platelets in trauma.Q38025621
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Emergency room management of patients with blunt major trauma: evaluation of the multislice computed tomography protocol exemplified by an urban trauma centerQ39792826
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Predicting intracranial lesions by antiplatelet agents in subjects with mild head injuryQ39855390
The prevalence of abnormal results of conventional coagulation tests on admission to a trauma centerQ39860149
Tourniquets revisitedQ39877184
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Sonographic assessment of blunt abdominal trauma: a 4-year prospective studyQ42042427
Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergenciesQ42046164
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Pelvic fracture classification: correlation with hemorrhageQ42079936
An analysis of in-hospital deaths at a modern combat support hospital.Q44533176
The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injuryQ44563085
Use of the "c-clamp" in the emergency treatment of unstable pelvic fracturesQ44592252
Aortic injuries in VietnamQ44601966
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The prognostic importance of trauma scoring systems in pediatric patientsQ44619354
Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trialQ44695998
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Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma).Q44818063
Impact of the duration of platelet storage in critically ill trauma patientsQ44843625
Correlation of serial blood lactate levels to organ failure and mortality after trauma.Q44851361
The utility of traditional prehospital interventions in maintaining thermostasisQ44860201
Delayed intracranial hemorrhage after blunt trauma: are patients on preinjury anticoagulants and prescription antiplatelet agents at risk?Q44885442
Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*.Q44919440
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Factor VIIa for correction of traumatic coagulopathyQ45130198
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Reduced platelet activity is associated with early clot growth and worse 3-month outcome after intracerebral hemorrhageQ45168826
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Abdominal Packing For Surgically Uncontrollable HemorrhageQ45277134
The natural history of trauma-related coagulopathy: implications for treatmentQ45369588
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Impact of plasma transfusion in trauma patients who do not require massive transfusionQ46055211
Prothrombin complex concentrate versus standard therapies for INR reversal in trauma patients receiving warfarinQ46080389
Reliable variables in the exsanguinated patient which indicate damage control and predict outcomeQ46100421
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Gelatin-thrombin-based hemostatic sealant for intraoperative bleeding in vascular surgeryQ46180325
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Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2.Q50549185
Effect of blood products transfusion on the development of postinjury multiple organ failure.Q50557639
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Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients.Q50631495
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Blood transfusion is an independent predictor of increased mortality in nonoperatively managed blunt hepatic and splenic injuries.Q50772580
Comparison of a new fibrin sealant with standard topical hemostatic agents.Q50781635
Ineffectiveness of on-site intravenous lines: is prehospital time the culprit?Q50926524
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Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography.Q51103642
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Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries.Q51591563
Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates.Q51598494
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Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy.Q51645772
Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortality.Q51790610
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Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity.Q53139741
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A prospective study of venous thromboembolism after major trauma.Q55065749
Transfusions in the Less Severely Injured: Does Age of Transfused Blood Affect Outcomes?Q56794868
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Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhageQ84752792
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Novel oral anticoagulants: new challenges for anesthesiologists in bleeding patientsQ85083465
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Early predictors of mortality in hemodynamically unstable pelvis fracturesQ36702715
Blood transfusion is an independent predictor of mortality after blunt trauma.Q36716976
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Packing for control of hemorrhage in major liver traumaQ36749933
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Role of anemia in traumatic brain injuryQ37250541
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Topical haemostatic agentsQ37258420
Local and systemic hemostatics in trauma: a review.Q37264348
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Early hypocalcemia in severe traumaQ81181442
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Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injuryQ81528136
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Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survivalQ81951543
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Packing for control of hepatic hemorrhageQ68802332
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Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patientQ69464615
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Serial lactate determinations during circulatory shockQ70433689
Lactate clearance and survival following injuryQ70508229
The role of packing and planned reoperation in severe hepatic traumaQ70623746
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Serum lactate is not predicted by anion gap or base excess after trauma resuscitationQ71093718
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Damage control surgeryQ74330512
Significance of the initial spun hematocrit in trauma patientsQ74363916
Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activityQ74593077
EXCESS LACTATE: AN INDEX OF REVERSIBILITY OF SHOCK IN HUMAN PATIENTSQ76689461
[Radiologic diagnosis of abdominal trauma]Q77361213
Surgeon-performed ultrasound for the assessment of truncal injuries: lessons learned from 1540 patientsQ77470238
Base deficit in the elderly: a marker of severe injury and deathQ77574428
Prevention of venous thromboembolism after injuryQ77853492
The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhageQ79333341
Guidelines on the management of massive blood lossQ79361874
Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhageQ79680727
Fibrinogen levels following Amicar in surgery for idiopathic scoliosisQ79702083
SSC International Collaborative Study to establish the first high fibrinogen plasma reference material for use with different fibrinogen assay techniquesQ80031634
[Possibilities and limitations of thrombelastometry/-graphy]Q80214023
[The role of whole body spiral CT in the primary work-up of polytrauma patients--comparison with conventional radiography and abdominal sonography]Q80523905
Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?Q80775991
Blunt trauma: feasibility and clinical utility of pelvic CT angiography performed with 64-detector row CT.Q33316927
Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysisQ33324731
Guidelines for the use of platelet transfusionsQ33348675
The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopeniaQ33387334
Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma AssociationQ33393028
Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagentsQ33395855
Prophylactic platelet administration during massive transfusion. A prospective, randomized, double-blind clinical studyQ33452902
Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysisQ33453304
Hemostasis in Massively Transfused Trauma PatientsQ33465463
PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trialQ33542800
Focused abdominal sonogram for trauma: the learning curve of nonradiologist clinicians in detecting hemoperitoneumQ33601751
Prior antiplatelet therapy, platelet infusion therapy, and outcome after intracerebral hemorrhage.Q33694337
Surgeon-performed ultrasound for the assessment of abdominal injuries.Q33779285
Management of haemophilia in patients with high-titre inhibitors: focus on the evolution of activated prothrombin complex concentrate AUTOPLEX T.Q33794083
Trauma-induced coagulopathy--a review of the systematic reviews: is there sufficient evidence to guide clinical transfusion practice?Q33837805
External fixation as a bridge to intramedullary nailing for patients with multiple injuries and with femur fractures: damage control orthopedicsQ33898695
Management of bleeding following major trauma: an updated European guidelineQ33919178
Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrateQ33919203
Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortalityQ33959509
Hypothermia, coagulopathy, and acidosisQ33969914
Bleeding and first-year mortality following hip fracture surgery and preoperative use of low-dose acetylsalicylic acid: an observational cohort studyQ34068661
Damage control: collective reviewQ34086936
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhageQ34137787
Damage control resuscitation: the new face of damage controlQ34142973
Systematic review and meta-analysis of emergency ultrasonography for blunt abdominal traumaQ34301645
Utility of platelet transfusion in adult patients with traumatic intracranial hemorrhage and preinjury antiplatelet use: a systematic review.Q34303300
Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuriesQ34324044
Pelvic ring disruptions: effective classification system and treatment protocolsQ34354160
'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury.Q34354386
Blood product ratio in acute traumatic coagulopathy--effect on mortality in a Scandinavian level 1 trauma centreQ34418999
Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic reviewQ34455124
Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trialQ34462765
Staged physiologic restoration and damage control surgeryQ34482323
Guidelines on oral anticoagulation (warfarin): third edition--2005 updateQ34484090
The coagulopathy of trauma: a review of mechanismsQ37292306
Predictors of mortality in trauma patients with intracranial hemorrhage on preinjury aspirin or clopidogrelQ37292319
Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma.Q37292331
Direct retroperitoneal pelvic packing versus pelvic angiography: A comparison of two management protocols for haemodynamically unstable pelvic fracturesQ37337586
Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventionsQ37390810
Diagnostic peritoneal lavage: a review of indications, technique, and interpretationQ37408385
Management of prehospital antiplatelet and anticoagulant therapy in traumatic head injury: a reviewQ37412009
Comparative results of trauma scoring systems in fatal outcomes.Q37481176
Early evaluation of acute traumatic coagulopathy by thrombelastographyQ37518734
Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation.Q37615642
Hemostatic resuscitation for massive bleeding: the paradigm of plasma and platelets--a review of the current literatureQ37636304
A retrospective review of patients with head injury with coexistent anticoagulant and antiplatelet use admitted from a UK emergency departmentQ37637640
Impact of mobile angiography in the emergency department for controlling pelvic fracture hemorrhage with hemodynamic instability.Q37672157
Antiplatelet and anticoagulation therapies do not increase mortality in the absence of traumatic brain injury.Q37672201
Does prehospital ultrasound improve treatment of the trauma patient? A systematic reviewQ37685943
Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastographyQ37707866
The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysisQ37719659
Trauma induced coagulopathyQ37732173
Should we increase the ratio of plasma/platelets to red blood cells in massive transfusion: what is the evidence?Q37740011
The use of clopidogrel (Plavix) in patients undergoing nonelective orthopaedic surgeryQ37760734
Comparison of emergency department point-of-care international normalised ratio (INR) testing with laboratory-based testingQ37761613
Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review.Q37774722
Incidence and Predictors of Intracranial Hemorrhage After Minor Head Trauma in Patients Taking Anticoagulant and Antiplatelet MedicationQ37778726
Novel oral anticoagulants: implications in the perioperative settingQ37779223
What is the utility of the Focused Assessment with Sonography in Trauma (FAST) exam in penetrating torso trauma?Q37779374
Standardization of thromboelastography: values and challengesQ37803380
The role of rotation thromboelastometry in early prediction of massive transfusionQ37819896
Antiplatelet drugs: a review of their pharmacology and management in the perioperative periodQ37826579
Update on the comparative safety of colloids: a systematic review of clinical studiesQ37827039
Coagulation management in multiple trauma: a systematic review.Q37841228
Survival of trauma patients after massive red blood cell transfusion using a high or low red blood cell to plasma transfusion ratioQ37845107
Damage control resuscitation: from emergency department to the operating room.Q37845341
The prognostic value of thrombelastography in identifying neurosurgical patients with worse prognosis.Q37862024
The effects of protocolized use of recombinant factor VIIa within a massive transfusion protocol in a civilian level I trauma center.Q46637436
The utility of base deficit and arterial lactate in differentiating major from minor injury in trauma patients with normal vital signs.Q46681795
Dose-response relationship between plasma ionized calcium concentration and thrombelastographyQ46682811
Control of bone bleeding at the sternum and iliac crest donor sites using a collagen-based composite combined with autologous plasma: results of a randomized controlled trialQ46692806
Impact of plasma transfusion in massively transfused trauma patientsQ46722289
Effect of crystalloid infusion on hematocrit in nonbleeding patients, with applications to clinical traumatologyQ46785234
Platelet activation and function after traumaQ46796249
Early use of vasopressors after injury: caution before constriction.Q46813452
Emergency reversal of clopidogrel in the setting of spontaneous intracerebral hemorrhageQ46827302
Whole-body MSCT of patients after polytrauma: abdominal injuriesQ46839984
Early coagulopathy in trauma patients: an on-scene and hospital admission study.Q46912713
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort studyQ46939952
Damage control management of experimental grade 5 renal injuries: further evaluation of FloSeal gelatin matrixQ46969382
New local hemostatic treatment for postpartum hemorrhage caused by placenta previa at cesarean sectionQ46983062
Improved survival after resuscitation with norepinephrine in a murine model of uncontrolled hemorrhagic shockQ46983469
"Low-dose" recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhageQ47256942
Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy.Q47322914
A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major traumaQ47324879
Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in traumaQ47438195
Tourniquet use in combat trauma: UK military experienceQ47581243
Packing and planned reexploration for hepatic and retroperitoneal hemorrhage: critical refinements of a useful techniqueQ47640153
Staged management and outcome of combined pelvic and liver trauma. An international experience of the deadly duo.Q47652265
Underuse of lung protective ventilation: analysis of potential factors to explain physician behaviorQ47653201
The role of acute blood transfusion in the development of acute respiratory distress syndrome in patients with severe trauma.Q47672539
Transfusions result in pulmonary morbidity and death after a moderate degree of injuryQ47747213
Early coagulopathy predicts mortality in traumaQ47766285
Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patientsQ47807515
The use of recombinant activated factor VIIa in coagulopathic traumatic brain injuries requiring emergent craniotomy: is it beneficial?Q47853018
Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating traumaQ47885477
Complications associated with prolonged tourniquet application on the battlefieldQ47933332
Purification, identification, and characterization of elastase on erythrocyte membrane as factor IX-activating enzymeQ47994639
Can RapidTEG accelerate the search for coagulopathies in the patient with multiple injuries?Q48023551
Induced hypothermia in traumatic brain injury: effective if properly employedQ48099878
High tidal volume is associated with the development of acute lung injury after severe brain injury: an international observational studyQ48136618
Reproducibility of thrombelastometry (ROTEM®): point-of-care versus hospital laboratory performanceQ48152762
Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.Q48217958
Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT studyQ48233664
Low-dose desmopressin improves hypothermia-induced impairment of primary haemostasis in healthy volunteersQ48234432
Patients with severe aortic valve stenosis and impaired platelet function benefit from preoperative desmopressin infusionQ48276514
Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrateQ48392324
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injuryQ48533116
Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary studyQ48588303
Severity of head injury is associated with increased risk of coagulopathy in combat casualtiesQ48619051
Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctorQ48635789
Outcome of resuscitative thoracotomy and descending aortic occlusion performed in the operating roomQ48673175
Transfusion improves cerebral oxygenation . . . but not alwaysQ48729383
Assessment of platelet transfusion for reversal of aspirin after traumatic brain injuryQ48839410
Packed red blood cell transfusion increases local cerebral oxygenationQ48887613
Emergency thoracotomy in thoracic trauma-a review.Q34484190
Transfusion of erythrocyte concentrates produces a variable increment on cerebral oxygenation in patients with severe traumatic brain injury: a preliminary study.Q34571528
Recombinant factor VIIa is associated with an improved 24-hour survival without an improvement in inpatient survival in massively transfused civilian trauma patientsQ34604004
Emergency reversal of anticoagulation with a three-factor prothrombin complex concentrate in patients with intracranial haemorrhageQ34626482
Mechanisms of thrombus formationQ34815800
A surgical safety checklist to reduce morbidity and mortality in a global populationQ34921953
Grading quality of evidence and strength of recommendations in clinical practice guidelines: Part 2 of 3. The GRADE approach to grading quality of evidence about diagnostic tests and strategiesQ34984432
Resuscitation in the pediatric trauma population: admission base deficit remains an important prognostic indicatorQ34999894
Mitochondria and ischemic reperfusion damage in the adult and in the developing brainQ35120759
Diagnosis and monitoring of hemorrhagic shock during the initial resuscitation of multiple trauma patients: a reviewQ35126791
The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction scoreQ35161940
Viscoelastic clot strength predicts coagulation-related mortality within 15 minutesQ35192620
Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysisQ35198491
A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patientsQ35219610
Abdominal vascular trauma: a review of 106 injuriesQ35446191
Emergency department ventilation effects outcome in severe traumatic brain injuryQ80776017
Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients)Q80838811
Ante- and postnatal risk factors of venous thrombosis: a hospital-based case-control studyQ80947501
Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injuryQ80988772
[Current concepts of polytrauma management: from ATLS to "damage control"]Q80998973
Definitive control of mortality from severe pelvic fractureQ44520473
Is it more dangerous to perform inadequate packing?Q42114943
Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trialQ42170476
A meta-analysis to determine the effect on survival of platelet transfusions in patients with either spontaneous or traumatic antiplatelet medication-associated intracranial haemorrhageQ42545904
A novel collagen-based composite offers effective hemostasis for multiple surgical indications: Results of a randomized controlled trialQ42646517
Evolution in damage control for exsanguinating penetrating abdominal injuryQ42656444
The impact of antiplatelet therapy on pelvic fracture outcomesQ42736172
Platelet Aggregation Inhibitors, Platelet Function Testing, and Blood Loss in Hip Fracture SurgeryQ42822385
Impact of platelet transfusion on hematoma expansion in patients receiving antiplatelet agents before intracerebral hemorrhageQ42916660
Antiplatelet agents, warfarin, and epidemic intracranial hemorrhageQ42930865
High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intakeQ42972705
Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding--a European perspectiveQ43055091
A comparison of Ringer's lactate and acetate solutions and resuscitative effects on splanchnic dysoxia in patients with extensive burnsQ43059764
Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry*.Q43061511
A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgeryQ43204646
Does platelet administration affect mortality in elderly head-injured patients taking antiplatelet medications?Q43238256
ROTEM®-guided coagulation factor concentrate therapy in trauma: 2-year experience in Venice, ItalyQ43241205
Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathyQ43254027
Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversalQ43269909
Simulation of survivorship bias in observational studies on plasma to red blood cell ratios in massive transfusion for trauma.Q43417609
Survival with emergency tourniquet use to stop bleeding in major limb trauma.Q43423147
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.Q43428425
The role of thoracic aortic occlusion for massive hemoperitoneum.Q43495913
The association between anemia and the mortality of severe traumatic brain injury in emergency departmentQ43565867
Test characteristics of focused assessment of sonography for trauma for clinically significant abdominal free fluid in pediatric blunt abdominal traumaQ43631966
Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study.Q43672752
Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood lossQ43700338
Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgery.Q43721237
Improved survival after hemostatic resuscitation: does the emperor have no clothes?Q43731626
Control of severe hemorrhage using C-clamp and pelvic packing in multiply injured patients with pelvic ring disruptionQ43768125
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?Q43777037
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusionQ43808177
Increasing hematocrit above 28% during early resuscitative phase is not associated with decreased mortality following severe traumatic brain injuryQ43842133
Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study'.Q43867973
Does tranexamic acid reduce desmopressin-induced hyperfibrinolysis?Q43908464
Accuracy and clinical utility of a portable coagulometer in an emergency setting.Q43941517
Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patientsQ43961306
Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma centerQ44002445
Activation of factor IX by erythrocyte membranes causes intrinsic coagulationQ44111899
Extraperitoneal pelvic packing: a salvage procedure to control massive traumatic pelvic hemorrhageQ44225500
Increased platelet:RBC ratios are associated with improved survival after massive transfusionQ44241574
Predictors of Death in Patients with Life-Threatening Pelvic Hemorrhage after Successful Transcatheter Arterial EmbolizationQ44241944
Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications.Q44253763
Coagulopathy and outcome in patients with chronic subdural haematomaQ44311438
The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injuryQ44360389
Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infectionQ44398924
Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion.Q44423540
Blood transfusion, independent of shock severity, is associated with worse outcome in traumaQ44460486
Recombinant activated factor VII for adjunctive hemorrhage control in traumaQ44472174
Massive hemorrhage in facial fracture patients: definition, incidence, and managementQ44477555
Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?Q44491498
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdisease managementQ883708
blood coagulation diseaseQ890200
polytraumaQ2103168
P304page(s)R76
P577publication date2013-04-19
P1433published inCritical CareQ5186602
P1476titleManagement of bleeding and coagulopathy following major trauma: an updated European guideline
P478volume17

Reverse relations

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Q37366934Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/- fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study
Q37186526Importance of fibrinogen in dilutional coagulopathy after neurosurgical procedures: A descriptive study
Q34416325In vitro combinations of red blood cell, plasma and platelet components evaluated by thromboelastography
Q36584522Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal
Q61448465Increased urokinase and consumption of α -antiplasmin as an explanation for the loss of benefit of tranexamic acid after treatment delay
Q47271338Influence of cryoprecipitate, Factor XIII, and fibrinogen concentrate on hyperfibrinolysis
Q38389488Infrastructure and clinical practice for the detection and management of trauma-associated haemorrhage and coagulopathy
Q91686808Initial Results of Empirical Cryoprecipitate Transfusion in the Treatment of Isolated Severe Traumatic Brain Injury: Use of In-house-produced Cryoprecipitate
Q35681126Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study.
Q36543599Interventional Algorithms for the Control of Coagulopathic Bleeding in Surgical, Trauma, and Postpartum Settings: Recommendations From the Share Network Group
Q37460935Intracranial hemorrhage and platelet transfusion after administration of anti-platelets agents: Fukushima Prefecture
Q39108165Is the shock index based classification of hypovolemic shock applicable in multiple injured patients with severe traumatic brain injury?-an analysis of the TraumaRegister DGU®.
Q37494761Is viscoelastic coagulation monitoring with ROTEM or TEG validated?
Q47722443Limitations of component therapy for massive haemorrhage: is whole blood the whole solution?
Q86077819Lumbar artery injury from which the Adamkiewicz artery originated associated with lumbar spine injury: successfully treated by transcatheter arterial embolization
Q40695425Management of bleeding following major trauma: is a target haemoglobin of 7 to 9 g/dl high enough?
Q26861537Management of postpartum haemorrhage
Q40148423Management of the anticoagulated trauma patient in the emergency department: a survey of current practice in England and Wales.
Q38273794Management of traumatic haemorrhage--the European perspective
Q30152076Mass casualty events: blood transfusion emergency preparedness across the continuum of care
Q34677761Massive bleeding following severe blunt trauma: the first minutes that can change everything
Q59802036Massive transfusion triggers in severe trauma: Scoping review
Q35831597Maxillofacial and neck trauma: a damage control approach
Q91711690Metabolic response to maxillofacial trauma revisited: A retrospective study
Q27316249Microcirculatory perfusion shows wide inter-individual variation and is important in determining shock reversal during resuscitation in a porcine experimental model of complex traumatic hemorrhagic shock
Q38712960Modern resuscitation of hemorrhagic shock: what is on the horizon?
Q57544005Monitoring the coagulation status of trauma patients with viscoelastic devices
Q33998905Mortality in severely injured children: experiences of a German level 1 trauma center (2002 - 2011).
Q38679908Necessity of Defining Different Transfusion Protocols for Different Kinds of Trauma Injuries
Q38203298New oral anticoagulants: clinical indications, monitoring and treatment of acute bleeding complications
Q48127422Non operative management of blunt splenic trauma: a prospective evaluation of a standardized treatment protocol
Q36670484Observational study of the effects of traumatic injury, haemorrhagic shock and resuscitation on the microcirculation: a protocol for the MICROSHOCK study.
Q45865634Off-label use of recombinant activated factor VII in surgical and non-surgical patients at 16 Canadian hospitals from 2007 to 2010 (Canadian Registry Report).
Q26744411Patient Blood Management Bundles to Facilitate Implementation
Q58768687Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma
Q48188617Performance of functional fibrinogen thromboelastography in children undergoing congenital heart surgery
Q50312912Perioperative management of the bleeding patient
Q35566697Perioperatively acquired disorders of coagulation.
Q52803485Peripartum Haemorrhage, Diagnosis and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No. 015/063, March 2016).
Q36949376Pharmacological adjuncts to stop bleeding: options and effectiveness.
Q37106075Pilot Randomized trial of Fibrinogen in Trauma Haemorrhage (PRooF-iTH): study protocol for a randomized controlled trial
Q27010188Point of care and factor concentrate-based coagulation algorithms
Q35972734Point of care coagulometry in prehospital emergency care: an observational study
Q33594504Point-of-care testing in the acute management of traumatic brain injury: Identifying the coagulopathic patient
Q36696328Polygeline in hypovolemia due to traumatic injury: Results of an open label study in Indian population
Q47313093Postauthorization safety study of Clottafact® , a triply secured fibrinogen concentrate in acquired fibrinogen deficiency: a prospective observational study
Q41911491Practical understanding of hemostasis and approach to the bleeding patient in the OR
Q38384814Practice management of acute trauma haemorrhage and haemostatic disorders across German trauma centres
Q64248084Pre-hospital plasma in haemorrhagic shock management: current opinion and meta-analysis of randomized trials
Q35642006Prediction of Post-Weaning Fibrinogen Status during Cardiopulmonary Bypass: An Observational Study in 110 Patients
Q36131647Preferential effects of low volume versus high volume replacement with crystalloid fluid in a hemorrhagic shock model in pigs
Q55283712Prehospital Index provides prognosis for hospitalized patients with acute trauma.
Q36898573Prehospital administration of tranexamic acid in trauma patients
Q34788925Prehospital identification of trauma patients with early acute coagulopathy and massive bleeding: results of a prospective non-interventional clinical trial evaluating the Trauma Induced Coagulopathy Clinical Score (TICCS).
Q88686949Prehospital tranexamic acid: what is the current evidence?
Q36769313Prehospital volume resuscitation--Did evidence defeat the crystalloid dogma? An analysis of the TraumaRegister DGU® 2002-2012.
Q33751742Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study.
Q35234231Preventable and potentially preventable deaths in severely injured elderly patients: a single-center retrospective data analysis of a German trauma center
Q38882039Preventable and potentially preventable deaths in severely injured patients: a retrospective analysis including patterns of errors
Q33430766Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting
Q53094595Prothrombin complex concentrate facilitates emergency spinal surgery in anticoagulated patients.
Q40765852Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model
Q42316665Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies
Q38663991Protocols for massive blood transfusion: when and why, and potential complications.
Q35896010Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England
Q36956183Rapid measurement of fibrinogen concentration in whole blood using a steel ball coagulometer
Q99203763Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins, and clotting factors for transfusion support in patients with hematologic disease
Q35807333Recombinant Activated Factor VII Significantly Reduces Transfusion Requirements in Cardiothoracic Surgery.
Q35670503Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia
Q36515685Recommendations for the implementation of a Patient Blood Management programme. Application to elective major orthopaedic surgery in adults.
Q40068086Recurring septic shock in a patient with blunt abdominal and pelvic trauma: how mandatory is source control surgery?: a case report
Q36726826Relationship between Obesity and Massive Transfusion Needs in Trauma Patients, and Validation of TASH Score in Obese Population: A Retrospective Study on 910 Trauma Patients.
Q35970337Resuscitation of Polytrauma Patients: The Management of Massive Skeletal Bleeding.
Q35545242Resuscitation strategies with different arterial pressure targets after surgical management of traumatic shock
Q38269290Reversal of anticoagulant effects in patients with intracerebral hemorrhage.
Q38831682Reversal of dabigatran by idarucizumab: when and how?
Q38543288Reversal of oral factor Xa inhibitors by prothrombin complex concentrates: a re-appraisal
Q38605790Rotational thromboelastometry significantly optimizes transfusion practices for damage control resuscitation in combat casualties
Q35039052Ruptured subcapsular hematoma of the liver complicating acute fatty liver of pregnancy
Q37352419Safety of a Four-factor Prothrombin Complex Concentrate Versus Plasma for Vitamin K Antagonist Reversal: An Integrated Analysis of Two Phase IIIb Clinical Trials
Q48294802Silk fibroin based carrier system for delivery of fibrinogen and thrombin as coagulant supplements.
Q55264101Standardised data reporting from pre-hospital advanced airway management - a nominal group technique update of the Utstein-style airway template.
Q35908338Surgical management of AAST grades III-V hepatic trauma by Damage control surgery with perihepatic packing and Definitive hepatic repair-single centre experience
Q35858739Synthetic Strategies for Engineering Intravenous Hemostats
Q37044657Systolic Blood Pressure Lower than Heart Rate upon Arrival at and Departure from the Emergency Department Indicates a Poor Outcome for Adult Trauma Patients
Q35091879TEG®- or ROTEM®-based individualized goal-directed coagulation algorithms: don't wait--act now!
Q37731832Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy
Q38400745Thawed and liquid plasma--what do we know?
Q49560572The British Rhinological Society multidisciplinary consensus recommendations on the hospital management of epistaxis
Q88666442The Double Hazard of Bleeding and Thrombosis in Hemostasis From a Clinical Point of View: A Global Assessment by Rotational Thromboelastometry (ROTEM)
Q64111058The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition
Q27339343The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition
Q50200375The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing
Q37193864The Quality of Pre-hospital Circulatory Management in Patients With Multiple Trauma Referred to the Trauma Center of Shahid Beheshti Hospital in Kashan, Iran, in the First Six Months of 2013
Q36902862The STOP the Bleeding Campaign
Q38213013The challenge in management of hemorrhagic shock in trauma
Q53060218The coagulopathy of trauma.
Q41471994The effect of preinjury warfarin use on mortality rates in trauma patients: a European multicentre study
Q40193621The haematological features and transfusion management of women who required massive transfusion for major obstetric haemorrhage in the UK: a population based study
Q91994221The impact of early administration of vasopressor agents for the resuscitation of severe hemorrhagic shock following blunt trauma
Q60920824The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review
Q38273793The pathogenesis of traumatic coagulopathy
Q35650554The pathophysiology, diagnosis and treatment of the acute coagulopathy of trauma and shock: a literature review
Q37326282The pre-hospital administration of tranexamic acid to patients with multiple injuries and its effects on rotational thrombelastometry: a prospective observational study in pre-hospital emergency medicine.
Q36509516The systemic immune response to trauma: an overview of pathophysiology and treatment
Q33852515The use of fibrinogen concentrate for the management of trauma-related bleeding: a systematic review and meta-analysis
Q42153351Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate
Q33429614Therapy with blood products
Q33419425Thromboelastometric Monitoring of the Hemostatic Effect of Platelet Concentrates Transfusion in Thrombocytopenic Children Undergoing Chemotherapy
Q34900934Tissue ischemia microdialysis assessments following severe traumatic haemorrhagic shock: lactate/pyruvate ratio as a new resuscitation end point?
Q35219638Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial
Q38427221Transfusion therapy in paediatric trauma patients: a review of the literature
Q34889509Trauma-Induced Coagulopathy
Q35248569Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs.
Q36841569Using the Reverse Shock Index at the Injury Scene and in the Emergency Department to Identify High-Risk Patients: A Cross-Sectional Retrospective Study
Q35631421Utilisation of Blood Components in Trauma Surgery: A Single-Centre, Retrospective Analysis before and after the Implementation of an Educative PBM Initiative
Q27026819Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials
Q33610825Vasopressor use following traumatic injury - A single center retrospective study
Q37681321Vasopressor use following traumatic injury: protocol for a systematic review
Q39245246Vasopressors: Do they have any role in hemorrhagic shock?
Q43830575Verifying the performance characteristics of the TEG5000 thromboelastogram in the clinical laboratory
Q26781050Viscoelastic Methods of Blood Clotting Assessment - A Multidisciplinary Review
Q26799203Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis
Q38227031What's new in management of traumatic coagulopathy?
Q33437019Wide variations in blood product transfusion practices among providers who care for patients with acute leukemia in the United States
Q87422024[Anesthesiological approach to postpartum hemorrhage]
Q30313497[Care for severely injured persons : Update of the 2016 S3 guideline for the treatment of polytrauma and the severely injured].
Q87203854[Coagulation therapy in multiple trauma without point-of-care testing]
Q88011652[Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey]
Q85283153[Fluid resuscitation in hemorrhage]
Q85635183[Individualized coagulation therapy: Wish or already reality?]
Q50634248[Interdisciplinary management of trauma patients : Update 3 years after implementation of the S3 guidelines on treatment of patients with severe and multiple injuries].
Q54127394[Oral anticoagulant-associated intracerebral haemorrhage].
Q87203851[Perioperative coagulation management in multiple trauma patients based on viscoelastic test results]
Q87203849[Point-of-care diagnostics compared to standard coagulation tests in multiple trauma. Pros and cons]
Q87060441[Prehospital assessment of injury type and severity in severely injured patients by emergency physicians : An analysis of the TraumaRegister DGU®]
Q87193864[Prehospital resuscitation of patients with multiple injuries]
Q53062878[Rotational thromboelastometry for the diagnosis of coagulation disorders].
Q52841804[Tranexamic acid in the German emergency medical service : A national survey].
Q86939566[Traumatic brain injury in anticoagulated patients : Hemostatic therapy for the treatment of intracranial hemorrhage]
Q88311054[Use of thrombelastography to guide posttraumatic hemostatic therapy: More coagulation factor concentrates and less allogenic blood transfusion?]

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