Abstract is: SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells. Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids. Sox2 holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.
| protein | Q8054 |
| P705 | Ensembl protein ID | ENSP00000376786 |
| ENSP00000433527 | ||
| P638 | PDB structure ID | 1CQT |
| P637 | RefSeq protein ID | NP_006226 |
| XP_005271650 | ||
| XP_005271651 | ||
| XP_006718922 | ||
| XP_006718923 | ||
| XP_016873421 | ||
| P352 | UniProt protein ID | Q16633 |
| P682 | biological process | regulation of transcription, DNA-templated | Q14633883 |
| transcription, DNA-templated | Q14763010 | ||
| positive regulation of transcription by RNA polymerase II | Q14818068 | ||
| humoral immune response | Q14863386 | ||
| transcription by RNA polymerase II | Q14864650 | ||
| P681 | cell component | nucleus | Q40260 |
| RNA polymerase II transcription regulator complex | Q21095257 | ||
| P702 | encoded by | POU2AF1 | Q18030664 |
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P680 | molecular function | protein binding | Q167149 |
| DNA binding | Q14633858 | ||
| transcription coactivator activity | Q14860440 | ||
| RNA polymerase II core promoter sequence-specific DNA binding | Q14864805 | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Q14885806 | ||
| transcription coregulator activity | Q14908256 | ||
| P361 | part of | POU, class 2, associating factor 1 | Q24743631 |
| Q24597591 | Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface |
| Q28191274 | Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator |
| Q24313516 | OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins |
| Q28910331 | Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding |
| Q18030664 | POU2AF1 | encodes | P688 |
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