E2F transcription factor 8

mammalian protein found in Homo sapiens

E2F transcription factor 8 is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDENSP00000250024
ENSP00000434199
ENSP00000437326
ENSP00000481103
P638PDB structure ID4YO2
P637RefSeq protein IDNP_001243300
NP_001243301
NP_078956
XP_011518669
P352UniProt protein IDA0AVK6

P682biological processplacenta developmentQ1114520
negative regulation of transcription by RNA polymerase IIQ14633878
chorionic trophoblast cell differentiationQ21103356
negative regulation of cytokinesisQ21105850
positive regulation of DNA endoreduplicationQ21105852
cell cycle comprising mitosis without cytokinesisQ21112257
cell cycleQ188941
cell population proliferationQ189101
regulation of cell cycleQ14818129
trophoblast giant cell differentiationQ14878788
sprouting angiogenesisQ14906343
hepatocyte differentiationQ14908220
regulation of transcription, DNA-templatedQ14633883
transcription, DNA-templatedQ14763010
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestQ14818020
positive regulation of transcription by RNA polymerase IIQ14818068
P681cell componentnucleusQ40260
nucleolusQ30869
cytosolQ220599
RNA polymerase II transcription regulator complexQ21095257
transcription regulator complexQ14818102
nucleoplasmQ14817956
P702encoded byE2F8Q18046307
P703found in taxonHomo sapiensQ15978631
P527has part(s)E2F/DP family, winged-helix DNA-binding domainQ24773372
P680molecular functionDNA bindingQ14633858
protein bindingQ167149
DNA-binding transcription repressor activity, RNA polymerase II-specificQ21097436
sequence-specific DNA bindingQ14818107
DNA-binding transcription factor activity, RNA polymerase II-specificQ14864645
transcription corepressor activityQ14864664
RNA polymerase II cis-regulatory region sequence-specific DNA bindingQ14885806
cis-regulatory region sequence-specific DNA bindingQ14888097
identical protein bindingQ14762994
protein homodimerization activityQ14762996
DNA-binding transcription activator activity, RNA polymerase II-specificQ14817973
DNA-binding transcription factor activityQ14817979
transcription factor bindingQ14817982
P361part ofE2F familyQ24771933
Winged helix-like DNA-binding domain superfamilyQ41797502
winged helix DNA-binding domain superfamilyQ41797505
E2F/DP family, winged-helix DNA-binding domain, protein familyQ83141032

Reverse relations

has part(s) (P527)
Q50290264E2F7 binds E2F8
Q50258059E2F7:E2F8 [nucleoplasm]
Q50290265E2F8 forms homodimers
Q50258060E2F8 homodimer [nucleoplasm]

main subject (P921)
Q24336562Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription
Q24296966E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1

Q18046307E2F8encodesP688