PYD and CARD domain containing

mammalian protein found in Homo sapiens

PYD and CARD domain containing is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDENSP00000247470
ENSP00000340441
ENSP00000455141
P638PDB structure ID1UCP
2KN6
3J63
5H8O
P637RefSeq protein IDNP_037390
NP_660183
P352UniProt protein IDQ9ULZ3

P682biological processproteolysisQ33123
innate immune responseQ428253
signal transductionQ828130
apoptotic processQ14599311
regulation of apoptotic processQ14633911
positive regulation of phagocytosisQ14633922
positive regulation of NF-kappaB transcription factor activityQ14761969
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorQ14818062
positive regulation of apoptotic processQ14818063
intrinsic apoptotic signaling pathway by p53 class mediatorQ14818086
positive regulation of release of cytochrome c from mitochondriaQ14818087
negative regulation of NF-kappaB transcription factor activityQ14819252
cellular response to interleukin-1Q14819490
inflammatory responseQ14819849
positive regulation of ERK1 and ERK2 cascadeQ14821388
intrinsic apoptotic signaling pathway in response to DNA damageQ14860450
regulation of inflammatory responseQ14860518
protein homooligomerizationQ14860815
activation of cysteine-type endopeptidase activity involved in apoptotic processQ14860870
positive regulation of actin filament polymerizationQ14863108
cellular response to lipopolysaccharideQ14863111
regulation of protein stabilityQ14863403
positive regulation of T cell migrationQ21095197
negative regulation of I-kappaB kinase/NF-kappaB signalingQ21095682
negative regulation of interferon-beta productionQ21100853
myeloid dendritic cell activation involved in immune responseQ21111822
macropinocytosisQ21111823
positive regulation of antigen processing and presentation of peptide antigen via MHC class IIQ21116452
myeloid dendritic cell activationQ22295776
regulation of intrinsic apoptotic signaling pathwayQ22303649
defense response to virusQ14863428
positive regulation of activated T cell proliferationQ14863695
tumor necrosis factor-mediated signaling pathwayQ14864211
regulation of autophagyQ14864247
positive regulation of DNA-binding transcription factor activityQ14864461
positive regulation of interferon-gamma productionQ14864505
positive regulation of interleukin-6 productionQ14864551
positive regulation of tumor necrosis factor productionQ14864552
positive regulation of T cell activationQ14864794
activation of innate immune responseQ14864910
positive regulation of JNK cascadeQ14864950
defense response to Gram-negative bacteriumQ14865229
regulation of cysteine-type endopeptidase activity involved in apoptotic processQ14873926
negative regulation of protein serine/threonine kinase activityQ14873995
cellular response to tumor necrosis factorQ14875882
positive regulation of cysteine-type endopeptidase activity involved in apoptotic processQ14877594
positive regulation of extrinsic apoptotic signaling pathwayQ14877596
positive regulation of adaptive immune responseQ14880375
positive regulation of cysteine-type endopeptidase activityQ14881863
response to bacteriumQ14885612
interleukin-1 beta productionQ14901961
positive regulation of interleukin-1 beta productionQ14903967
regulation of GTPase activityQ14906012
activation of cysteine-type endopeptidase activityQ14907136
negative regulation of cytokine production involved in inflammatory responseQ14910955
neutrophil degranulationQ14911651
regulation of tumor necrosis factor-mediated signaling pathwayQ14913821
positive regulation of defense response to virus by hostQ14916099
immune system processQ14916317
P681cell componentnucleolusQ30869
mitochondrionQ39572
endoplasmic reticulumQ79927
Golgi apparatusQ83181
cytoplasmQ79899
cytosolQ220599
nucleusQ40260
membraneQ14349455
Golgi membraneQ14598778
extracellular regionQ14645596
neuronal cell bodyQ14645696
secretory granule lumenQ14758893
azurophil granule lumenQ21101057
protein-containing complexQ22325163
NLRP1 inflammasome complexQ14901955
NLRP3 inflammasome complexQ14901956
AIM2 inflammasome complexQ14901957
IkappaB kinase complexQ14908207
P702encoded byPYCARDQ18039614
P703found in taxonHomo sapiensQ15978631
P680molecular functionprotein bindingQ167149
enzyme bindingQ14599289
protease bindingQ14758894
identical protein bindingQ14762994
protein homodimerization activityQ14762996
protein dimerization activityQ14861864
myosin I bindingQ21116453
Pyrin domain bindingQ21116454
cysteine-type endopeptidase activityQ14864228
interleukin-6 receptor bindingQ14865211
transmembrane transporter bindingQ14901685
cysteine-type endopeptidase activator activity involved in apoptotic processQ14901958
BMP receptor bindingQ14903105
tropomyosin bindingQ14906726
cysteine-type endopeptidase activity involved in apoptotic processQ14911967

Reverse relations

has part(s) (P527)
Q107515475AIM2 inflammasome
Q50292300ASC binds Caspase-8 complex
Q50262387Azurophil granule lumen proteins [azurophil granule lumen]
Q50262391Azurophil granule lumen proteins [extracellular region]
Q50262113MALT1 oligomers:active caspase-8:ASC [cytosol]
Q107515483NLRC4 inflammasome
Q107515458NLRP1 inflammasome
Q50261484NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol]
Q107515472NLRP3 inflammasome
Q50291982NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction
Q50291987Pyrin binds ASC
Q107515480Pyrin inflammasome
Q50261494Pyrin trimer:ASC [cytosol]
Q50262432Secretory granule lumen proteins [extracellular region]
Q50262429Secretory granule lumen proteins [secretory granule lumen]
Q50291999dsDNA:AIM2 clusters bind ASC
Q50261513dsDNA:AIM2 oligomer:ASC [cytosol]

main subject (P921)
Q24319765AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Q24319706AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Q24313497ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
Q24305337ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
Q24298063ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis
Q24319799An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Q24338908Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells
Q24303839Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways
Q24303046Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
Q45353531Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation
Q24302985IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
Q30668589Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly
Q24316478Mechanism and repertoire of ASC-mediated gene expression
Q24302312Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells
Q24317771NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
Q34409679PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion
Q24297724PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing
Q24318667Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation
Q24299627The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome
Q24337186The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
Q24298443The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation
Q28391800The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
Q24305136The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
Q24339219Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

Q18039614PYCARDencodesP688

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