fms related receptor tyrosine kinase 4

mammalian protein found in Homo sapiens

Wikidata entity: Q21118353



P682 biological process ... Q210861 (cell differentiation) cell differentiation
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q539568 (angiogenesis) angiogenesis
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q6708231 (lymphangiogenesis) lymphangiogenesis
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14330982 (positive regulation of phosphatidylinositol 3-kinase signaling) positive regulation of phosphatidylinositol 3-kinase signaling
P682 biological process ... Q14330986 (peptidyl-tyrosine phosphorylation) peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14633891 (positive regulation of cell population proliferation) positive regulation of cell population proliferation
P682 biological process ... Q14758936 (positive regulation of MAPK cascade) positive regulation of MAPK cascade
P682 biological process ... Q14905259 (cellular response to vascular endothelial growth factor stimulus) cellular response to vascular endothelial growth factor stimulus
P682 biological process ... Q14905608 (lymph vessel development) lymph vessel development
P682 biological process ... Q14906343 (sprouting angiogenesis) sprouting angiogenesis
P682 biological process ... Q14912397 (vascular endothelial growth factor signaling pathway) vascular endothelial growth factor signaling pathway
P682 biological process ... Q15330596 (regulation of blood vessel remodeling) regulation of blood vessel remodeling
P682 biological process ... Q14819846 (positive regulation of protein phosphorylation) positive regulation of protein phosphorylation
P682 biological process ... Q14820063 (lung alveolus development) lung alveolus development
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14859610 (positive regulation of endothelial cell migration) positive regulation of endothelial cell migration
P682 biological process ... Q14860122 (vasculature development) vasculature development
P682 biological process ... Q14863362 (transmembrane receptor protein tyrosine kinase signaling pathway) transmembrane receptor protein tyrosine kinase signaling pathway
P682 biological process ... Q14864089 (respiratory gaseous exchange by respiratory system) respiratory gaseous exchange by respiratory system
P682 biological process ... Q14864950 (positive regulation of JNK cascade) positive regulation of JNK cascade
P682 biological process ... Q14864951 (blood vessel morphogenesis) blood vessel morphogenesis
P682 biological process ... Q14865064 (positive regulation of endothelial cell proliferation) positive regulation of endothelial cell proliferation
P682 biological process ... Q14874313 (positive regulation of vascular endothelial growth factor production) positive regulation of vascular endothelial growth factor production
P682 biological process ... Q14885636 (vascular endothelial growth factor receptor signaling pathway) vascular endothelial growth factor receptor signaling pathway
P682 biological process ... Q14905137 (negative regulation of signal transduction) negative regulation of signal transduction
P682 biological process ... Q21101610 (respiratory system process) respiratory system process
P682 biological process ... Q21113807 (positive regulation of protein kinase C signaling) positive regulation of protein kinase C signaling
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q14327652 (integral component of membrane) integral component of membrane
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14645596 (extracellular region) extracellular region
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q14859540 (integral component of plasma membrane) integral component of plasma membrane
P681 cell component ... Q14877465 (receptor complex) receptor complex
P702 encoded by ... Q17928864 (FLT4) FLT4
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24719835 (tyrosine-protein kinase, catalytic domain) tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24738472 (tyrosine-protein kinase, active site) tyrosine-protein kinase, active site
P527 has part(s) ... Q24740842 (serine-threonine/tyrosine-protein kinase, catalytic domain) serine-threonine/tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24771265 (tyrosine-protein kinase, receptor class III, conserved site) tyrosine-protein kinase, receptor class III, conserved site
P527 has part(s) ... Q24772334 (immunoglobulin I-set) immunoglobulin I-set
P527 has part(s) ... Q24774513 (immunoglobulin subtype 2) immunoglobulin subtype 2
P527 has part(s) ... Q24783253 (immunoglobulin-like domain) immunoglobulin-like domain
P527 has part(s) ... Q24786036 (immunoglobulin subtype) immunoglobulin subtype
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q420511 (receptor tyrosine kinase) receptor tyrosine kinase
P680 molecular function ... Q14762996 (protein homodimerization activity) protein homodimerization activity
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14912386 (vascular endothelial growth factor-activated receptor activity) vascular endothelial growth factor-activated receptor activity
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14863060 (protein phosphatase binding) protein phosphatase binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14863338 (protein tyrosine kinase activity) protein tyrosine kinase activity
P680 molecular function ... Q14863358 (transmembrane receptor protein tyrosine kinase activity) transmembrane receptor protein tyrosine kinase activity
P680 molecular function ... Q14864356 (transmembrane signaling receptor activity) transmembrane signaling receptor activity
P680 molecular function ... Q14877469 (growth factor binding) growth factor binding
P680 molecular function ... Q21102505 (vascular endothelial growth factor binding) vascular endothelial growth factor binding
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q24769887 (vascular endothelial growth factor receptor 3 (VEGFR3)) vascular endothelial growth factor receptor 3 (VEGFR3)
P361 part of ... Q24787648 (Immunoglobulin-like fold) Immunoglobulin-like fold
P361 part of ... Q41797304 (Immunoglobulin-like domain superfamily) Immunoglobulin-like domain superfamily
P361 part of ... Q83130430 (Tyrosine-protein kinase, catalytic domain, protein family) Tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83137014 (Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family) Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q83141582 (Immunoglobulin subtype 2, protein family) Immunoglobulin subtype 2, protein family
P361 part of ... Q83145952 (Immunoglobulin I-set, protein family) Immunoglobulin I-set, protein family
P361 part of ... Q83163490 (immunoglobulin-like domain, protein family) immunoglobulin-like domain, protein family
P361 part of ... Q83165367 (immunoglobulin subtype, protein family) immunoglobulin subtype, protein family
P361 part of ... Q95352117 (Tyrosine-protein kinase, receptor class III, conserved site, protein family) Tyrosine-protein kinase, receptor class III, conserved site, protein family
P361 part of ... Q95352684 (Tyrosine-protein kinase, active site, protein family) Tyrosine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P129 physically interacts with ... Q417542 (sunitinib) sunitinib
P129 physically interacts with ... Q5057052 (cediranib) cediranib
P129 physically interacts with ... Q6523413 (lenvatinib) lenvatinib
P129 physically interacts with ... Q6554172 (linifanib) linifanib
P129 physically interacts with ... Q6917202 (motesanib) motesanib
P129 physically interacts with ... Q7157043 (pazopanib) pazopanib
P129 physically interacts with ... Q7810457 (tivozanib) tivozanib
P129 physically interacts with ... Q7917084 (vatalanib) vatalanib
P129 physically interacts with ... Q15149723 (nintedanib) nintedanib
P129 physically interacts with ... Q27075363 (bms-690514) bms-690514
P129 physically interacts with ... Q27075503 (brivanib) brivanib
P129 physically interacts with ... Q27075849 (cep-11981) cep-11981
P129 physically interacts with ... Q27077275 (famitinib) famitinib
P129 physically interacts with ... Q27082198 (lucitanib) lucitanib
P129 physically interacts with ... Q27089134 (VEGF receptor tyrosine kinase inhibitor III) VEGF receptor tyrosine kinase inhibitor III

External Ids
P705Ensembl protein IDENSP00000481134
P705Ensembl protein IDENSP00000426057
P705Ensembl protein IDENSP00000377016
P705Ensembl protein IDENSP00000421535
P705Ensembl protein IDENSP00000261937
P486MeSH descriptor IDD040321
P672MeSH tree codeD08.811.913.696.620.682.725.400.950.300
P672MeSH tree codeD12.776.476.568.400.950.300
P672MeSH tree codeD12.776.543.750.630.750.300
P672MeSH tree codeD12.776.543.750.750.400.910.300
P638PDB structure ID4BSK
P638PDB structure ID4BSJ
P637RefSeq protein IDNP_001341918
P637RefSeq protein IDNP_002011
P637RefSeq protein IDNP_891555
P637RefSeq protein IDXP_011532780
P637RefSeq protein IDXP_011532786
P637RefSeq protein IDXP_016864752
P637RefSeq protein IDXP_016864753
P637RefSeq protein IDXP_016864754
P637RefSeq protein IDXP_016864755
P637RefSeq protein IDXP_016864756
P637RefSeq protein IDXP_016864757
P2892UMLS CUIC0169539
P352UniProt protein IDP35916

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