Proteasome 20S subunit alpha 8

mammalian protein found in Homo sapiens

Wikidata entity: Q21124971



P682 biological process ... Q33123 (proteolysis) proteolysis
P682 biological process ... Q898362 (post-translational protein modification) post-translational protein modification
P682 biological process ... Q14633881 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent) antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
P682 biological process ... Q14758900 (MAPK cascade) MAPK cascade
P682 biological process ... Q14758906 (regulation of cellular amino acid metabolic process) regulation of cellular amino acid metabolic process
P682 biological process ... Q14820680 (transmembrane transport) transmembrane transport
P682 biological process ... Q14852022 (regulation of transcription from RNA polymerase II promoter in response to hypoxia) regulation of transcription from RNA polymerase II promoter in response to hypoxia
P682 biological process ... Q14860027 (negative regulation of canonical Wnt signaling pathway) negative regulation of canonical Wnt signaling pathway
P682 biological process ... Q14860483 (positive regulation of canonical Wnt signaling pathway) positive regulation of canonical Wnt signaling pathway
P682 biological process ... Q14863376 (protein polyubiquitination) protein polyubiquitination
P682 biological process ... Q14863970 (T cell receptor signaling pathway) T cell receptor signaling pathway
P682 biological process ... Q14864211 (tumor necrosis factor-mediated signaling pathway) tumor necrosis factor-mediated signaling pathway
P682 biological process ... Q14864233 (ubiquitin-dependent protein catabolic process) ubiquitin-dependent protein catabolic process
P682 biological process ... Q14864234 (protein deubiquitination) protein deubiquitination
P682 biological process ... Q14864810 (interleukin-1-mediated signaling pathway) interleukin-1-mediated signaling pathway
P682 biological process ... Q14874299 (Fc-epsilon receptor signaling pathway) Fc-epsilon receptor signaling pathway
P682 biological process ... Q14897651 (Wnt signaling pathway, planar cell polarity pathway) Wnt signaling pathway, planar cell polarity pathway
P682 biological process ... Q14905468 (proteasomal protein catabolic process) proteasomal protein catabolic process
P682 biological process ... Q14905689 (regulation of hematopoietic stem cell differentiation) regulation of hematopoietic stem cell differentiation
P682 biological process ... Q14905702 (anaphase-promoting complex-dependent catabolic process) anaphase-promoting complex-dependent catabolic process
P682 biological process ... Q14907360 (regulation of mRNA stability) regulation of mRNA stability
P682 biological process ... Q14911964 (proteolysis involved in cellular protein catabolic process) proteolysis involved in cellular protein catabolic process
P682 biological process ... Q15323465 (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
P682 biological process ... Q15323482 (proteasome-mediated ubiquitin-dependent protein catabolic process) proteasome-mediated ubiquitin-dependent protein catabolic process
P682 biological process ... Q21095148 (regulation of mitotic cell cycle phase transition) regulation of mitotic cell cycle phase transition
P682 biological process ... Q21095173 (stimulatory C-type lectin receptor signaling pathway) stimulatory C-type lectin receptor signaling pathway
P682 biological process ... Q21100852 (NIK/NF-kappaB signaling) NIK/NF-kappaB signaling
P682 biological process ... Q21103083 (negative regulation of G2/M transition of mitotic cell cycle) negative regulation of G2/M transition of mitotic cell cycle
P682 biological process ... Q21104750 (proteasomal ubiquitin-independent protein catabolic process) proteasomal ubiquitin-independent protein catabolic process
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q903634 (extracellular exosome) extracellular exosome
P681 cell component ... Q14878333 (proteasome complex) proteasome complex
P681 cell component ... Q21101365 (proteasome core complex) proteasome core complex
P681 cell component ... Q21104751 (proteasome core complex, alpha-subunit complex) proteasome core complex, alpha-subunit complex
P681 cell component ... Q21111804 (spermatoproteasome complex) spermatoproteasome complex
P702 encoded by ... Q18051076 (PSMA8) PSMA8
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24774364 (Proteasome alpha-subunit, N-terminal domain) Proteasome alpha-subunit, N-terminal domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q14353168 (hydrolase activity) hydrolase activity
P680 molecular function ... Q14645703 (peptidase activity) peptidase activity
P680 molecular function ... Q14861555 (endopeptidase activity) endopeptidase activity
P680 molecular function ... Q21104748 (threonine-type endopeptidase activity) threonine-type endopeptidase activity
P361 part of ... Q24775249 (Nucleophile aminohydrolases, N-terminal) Nucleophile aminohydrolases, N-terminal
P361 part of ... Q83141707 (Proteasome alpha-subunit, N-terminal domain, protein family) Proteasome alpha-subunit, N-terminal domain, protein family
P129 physically interacts with ... Q15366934 (carfilzomib) carfilzomib
P129 physically interacts with ... Q20948663 (ixazomib) ixazomib
P129 physically interacts with ... Q25104721 (Oprozomib) Oprozomib

External Ids
P705Ensembl protein IDENSP00000482057
P705Ensembl protein IDENSP00000440327
P705Ensembl protein IDENSP00000409284
P705Ensembl protein IDENSP00000345584
P705Ensembl protein IDENSP00000311121
P638PDB structure ID4R67
P638PDB structure ID4R3O
P637RefSeq protein IDNP_001020267
P637RefSeq protein IDNP_001020268
P637RefSeq protein IDNP_001295117
P637RefSeq protein IDNP_653263
P637RefSeq protein IDXP_011524120
P352UniProt protein IDQ8TAA3

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