Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity

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Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...731293G
P356DOI10.1371/JOURNAL.PONE.0031293
P932PMC publication ID3276573
P698PubMed publication ID22347458
P5875ResearchGate publication ID221844860

P2093author name stringGerolamo Lanfranchi
Lucia Celotti
Gabriele Sales
Cristiano De Pittà
Maddalena Mognato
Cristina Girardi
Silvia Casara
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
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Changes in MicroRNA expression patterns in human fibroblasts after low-LET radiationQ34814328
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A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosisQ54399995
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Modeled microgravity affects cell survival and HPRT mutant frequency, but not the expression of DNA repair genes in human lymphocytes irradiated with ionising radiation.Q54653417
Effects of 17-day spaceflight on electrically evoked torque and cross-sectional area of the human triceps suraeQ58809007
Induction and repair of DNA double-strand breaks under irradiation and microgravityQ64388588
Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttleQ73031229
cDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat)Q74299266
The effect of space radiation on the induction of chromosome damageQ77449989
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MicroRNAs as tumor suppressorsQ80220517
Impact of simulated microgravity on microvascular endothelial cell apoptosisQ83348058
HUVEC respond to radiation by inducing the expression of pro-angiogenic microRNAsQ83504044
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemiaQ36288982
Does reduced gravity alter cellular response to ionizing radiation?Q36416281
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The role of microRNAs in cancer: no small matter.Q36832677
microRNAs and the regulation of glucose and lipid metabolismQ36962177
Signal transduction in cells of the immune system in microgravityQ36975154
Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistanceQ37097112
Gene expression profiling of human epidermal keratinocytes in simulated microgravity and recovery culturesQ37318321
Increasing MicroRNA target prediction confidence by the relative R(2) methodQ37347923
Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cellsQ37397551
How to control miRNA maturation?Q37624378
Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation.Q38307992
miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2.Q38342369
Immune system dysregulation following short- vs long-duration spaceflightQ38475764
Radiation modulation of microRNA in prostate cancer cell linesQ38583993
Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptationQ39619574
Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated regionQ39733975
miR-181a and miR-630 regulate cisplatin-induced cancer cell deathQ39741509
Alteration of miRNA profiles by ionizing radiation in A549 human non-small cell lung cancer cells.Q39840179
Identification of ionizing radiation-responsive microRNAs in the IM9 human B lymphoblastic cell lineQ39855119
The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cellsQ39855685
Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytesQ39856833
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cellsQ39859199
Real-time PCR analysis of micro-RNA expression in ionizing radiation-treated cellsQ39884020
Exercise in space: human skeletal muscle after 6 months aboard the International Space Station.Q40009558
Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity: impact of vascular endothelial growth factorQ40306594
"Modeled microgravity" affects cell response to ionizing radiation and increases genomic damage.Q40469165
Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells.Q40741876
DNA repair in microgravity: studies on bacteria and mammalian cells in the experiments REPAIR and KINETICS.Q41190466
Direct and sensitive miRNA profiling from low-input total RNA.Q41500041
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage responseQ41911349
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Intact T cell receptor signaling by CD4(+) T cells cultured in the rotating wall-vessel bioreactorQ43176102
X-ray-induced chromosome aberrations in human lymphocytes in vitro are potentiated under simulated microgravity conditions (Clinostat).Q43847367
Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c releaseQ44378751
Modelled microgravity does not modify the yield of chromosome aberrations induced by high-energy protons in human lymphocytesQ46601060
Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat).Q47675848
DNA repair in modeled microgravity: double strand break rejoining activity in human lymphocytes irradiated with gamma-raysQ47844419
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCytoscapeQ3699942
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmicrogravityQ48655
P304page(s)e31293
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleAnalysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity
P478volume7

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