DNA-(apurinic or apyrimidinic site) lyase

human protein

Wikidata entity: Q21137455



P682 biological process ... Q210538 (DNA repair) DNA repair
P682 biological process ... Q332154 (ageing) ageing
P682 biological process ... Q5205753 (DNA demethylation) DNA demethylation
P682 biological process ... Q14633883 (regulation of transcription, DNA-templated) regulation of transcription, DNA-templated
P682 biological process ... Q14633911 (regulation of apoptotic process) regulation of apoptotic process
P682 biological process ... Q14763010 (transcription, DNA-templated) transcription, DNA-templated
P682 biological process ... Q14818011 (base-excision repair) base-excision repair
P682 biological process ... Q14818018 (cellular response to DNA damage stimulus) cellular response to DNA damage stimulus
P682 biological process ... Q14862222 (DNA recombination) DNA recombination
P682 biological process ... Q14864027 (negative regulation of smooth muscle cell migration) negative regulation of smooth muscle cell migration
P682 biological process ... Q14864049 (cellular response to cAMP) cellular response to cAMP
P682 biological process ... Q14864433 (response to organonitrogen compound) response to organonitrogen compound
P682 biological process ... Q14864622 (cell redox homeostasis) cell redox homeostasis
P682 biological process ... Q14865235 (cellular response to hydrogen peroxide) cellular response to hydrogen peroxide
P682 biological process ... Q14872783 (telomere maintenance) telomere maintenance
P682 biological process ... Q14905036 (cellular response to organonitrogen compound) cellular response to organonitrogen compound
P682 biological process ... Q14905665 (cellular response to peptide hormone stimulus) cellular response to peptide hormone stimulus
P682 biological process ... Q14907360 (regulation of mRNA stability) regulation of mRNA stability
P682 biological process ... Q14908225 (positive regulation of G1/S transition of mitotic cell cycle) positive regulation of G1/S transition of mitotic cell cycle
P682 biological process ... Q15311580 (nucleic acid phosphodiester bond hydrolysis) nucleic acid phosphodiester bond hydrolysis
P682 biological process ... Q21095680 (RNA phosphodiester bond hydrolysis, endonucleolytic) RNA phosphodiester bond hydrolysis, endonucleolytic
P682 biological process ... Q21096397 (negative regulation of nucleic acid-templated transcription) negative regulation of nucleic acid-templated transcription
P682 biological process ... Q22253561 (positive regulation of nucleic acid-templated transcription) positive regulation of nucleic acid-templated transcription
P682 biological process ... Q22272252 (telomere maintenance via base-excision repair) telomere maintenance via base-excision repair
P681 cell component ... Q30869 (nucleolus) nucleolus
P681 cell component ... Q39572 (mitochondrion) mitochondrion
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q42244 (ribosome) ribosome
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q79927 (endoplasmic reticulum) endoplasmic reticulum
P681 cell component ... Q190769 (centrosome) centrosome
P681 cell component ... Q3824358 (intracellular anatomical structure) intracellular anatomical structure
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q14818102 (transcription regulator complex) transcription regulator complex
P681 cell component ... Q14819271 (nuclear speck) nuclear speck
P702 encoded by ... Q5945174 (APEX1) APEX1
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24777764 (Endonuclease/exonuclease/phosphatase) Endonuclease/exonuclease/phosphatase
P527 has part(s) ... Q24778012 (AP endonuclease 1, binding site) AP endonuclease 1, binding site
P527 has part(s) ... Q24781898 (AP endonuclease 1, conserved site) AP endonuclease 1, conserved site
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q14330639 (RNA binding) RNA binding
P680 molecular function ... Q14349613 (oxidoreductase activity) oxidoreductase activity
P680 molecular function ... Q14353168 (hydrolase activity) hydrolase activity
P680 molecular function ... Q14633858 (DNA binding) DNA binding
P680 molecular function ... Q14817978 (damaged DNA binding) damaged DNA binding
P680 molecular function ... Q14859873 (lyase activity) lyase activity
P680 molecular function ... Q14860440 (transcription coactivator activity) transcription coactivator activity
P680 molecular function ... Q14864664 (transcription corepressor activity) transcription corepressor activity
P680 molecular function ... Q14865583 (phosphoric diester hydrolase activity) phosphoric diester hydrolase activity
P680 molecular function ... Q14865606 (NF-kappaB binding) NF-kappaB binding
P680 molecular function ... Q14877415 (endoribonuclease activity) endoribonuclease activity
P680 molecular function ... Q14877427 (nuclease activity) nuclease activity
P680 molecular function ... Q14877428 (endonuclease activity) endonuclease activity
P680 molecular function ... Q14880772 (chromatin DNA binding) chromatin DNA binding
P680 molecular function ... Q14883719 (exonuclease activity) exonuclease activity
P680 molecular function ... Q14883720 (3'-5' exonuclease activity) 3'-5' exonuclease activity
P680 molecular function ... Q14912158 (DNA-(apurinic or apyrimidinic site) endonuclease activity) DNA-(apurinic or apyrimidinic site) endonuclease activity
P680 molecular function ... Q14913991 (phosphodiesterase I activity) phosphodiesterase I activity
P680 molecular function ... Q34352927 (class I DNA-(apurinic or apyrimidinic site) endonuclease activity) class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P680 molecular function ... Q34352931 (class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity) class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity
P680 molecular function ... Q21109603 (double-stranded telomeric DNA binding) double-stranded telomeric DNA binding
P680 molecular function ... Q21111913 (uracil DNA N-glycosylase activity) uracil DNA N-glycosylase activity
P680 molecular function ... Q21116612 (double-stranded DNA 3'-5' exodeoxyribonuclease activity) double-stranded DNA 3'-5' exodeoxyribonuclease activity
P680 molecular function ... Q21117501 (site-specific endodeoxyribonuclease activity, specific for altered base) site-specific endodeoxyribonuclease activity, specific for altered base
P680 molecular function ... Q21120554 (RNA-DNA hybrid ribonuclease activity) RNA-DNA hybrid ribonuclease activity
P680 molecular function ... Q21154943 (double-stranded DNA exodeoxyribonuclease activity) double-stranded DNA exodeoxyribonuclease activity
P680 molecular function ... Q22279927 (endodeoxyribonuclease activity) endodeoxyribonuclease activity
P680 molecular function ... Q22312857 (protein-containing complex binding) protein-containing complex binding
P361 part of ... Q24767094 (AP endonuclease 1) AP endonuclease 1
P361 part of ... Q41797791 (Endonuclease/exonuclease/phosphatase superfamily) Endonuclease/exonuclease/phosphatase superfamily
P361 part of ... Q83146465 (Endonuclease/exonuclease/phosphatase family) Endonuclease/exonuclease/phosphatase family
P361 part of ... Q95351085 (AP endonuclease 1, conserved site, protein family) AP endonuclease 1, conserved site, protein family
P361 part of ... Q95352023 (AP endonuclease 1, binding site, protein family) AP endonuclease 1, binding site, protein family
P279 subclass of ... Q8054 (protein) protein

External Ids
P705Ensembl protein IDENSP00000450604
P705Ensembl protein IDENSP00000216714
P705Ensembl protein IDENSP00000452418
P705Ensembl protein IDENSP00000452460
P705Ensembl protein IDENSP00000452304
P705Ensembl protein IDENSP00000381111
P705Ensembl protein IDENSP00000451327
P705Ensembl protein IDENSP00000451060
P705Ensembl protein IDENSP00000452212
P705Ensembl protein IDENSP00000451170
P705Ensembl protein IDENSP00000451491
P705Ensembl protein IDENSP00000416414
P705Ensembl protein IDENSP00000452137
P705Ensembl protein IDENSP00000451979
P486MeSH descriptor IDC085108
P638PDB structure ID5DFH
P638PDB structure ID1HD7
P638PDB structure ID1DEW
P638PDB structure ID2O3H
P638PDB structure ID1E9N
P638PDB structure ID5DFI
P638PDB structure ID1BIX
P638PDB structure ID5DFF
P638PDB structure ID1DE9
P638PDB structure ID5DG0
P638PDB structure ID1DE8
P638PDB structure ID5DFJ
P638PDB structure ID4IEM
P638PDB structure ID1CQG
P638PDB structure ID1CQH
P638PDB structure ID2ISI
P638PDB structure ID3U8U
P638PDB structure ID4LND
P638PDB structure ID4QH9
P638PDB structure ID4QHD
P638PDB structure ID4QHE
P638PDB structure ID5CFG
P637RefSeq protein IDNP_001231178
P637RefSeq protein IDNP_001632
P637RefSeq protein IDNP_542379
P637RefSeq protein IDNP_542380
P2892UMLS CUIC0140145
P352UniProt protein IDP27695

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