fibroblast growth factor receptor 4

mammalian protein found in Homo sapiens

Wikidata entity: Q21137668



P682 biological process ... Q189092 (cell migration) cell migration
P682 biological process ... Q210861 (cell differentiation) cell differentiation
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q539568 (angiogenesis) angiogenesis
P682 biological process ... Q1345738 (nervous system development) nervous system development
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14330986 (peptidyl-tyrosine phosphorylation) peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14633891 (positive regulation of cell population proliferation) positive regulation of cell population proliferation
P682 biological process ... Q14633893 (positive regulation of gene expression) positive regulation of gene expression
P682 biological process ... Q14758900 (MAPK cascade) MAPK cascade
P682 biological process ... Q14758934 (glucose homeostasis) glucose homeostasis
P682 biological process ... Q14761970 (positive regulation of protein kinase B signaling) positive regulation of protein kinase B signaling
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q21109886 (regulation of extracellular matrix disassembly) regulation of extracellular matrix disassembly
P682 biological process ... Q22273386 (response to bile acid) response to bile acid
P682 biological process ... Q14863362 (transmembrane receptor protein tyrosine kinase signaling pathway) transmembrane receptor protein tyrosine kinase signaling pathway
P682 biological process ... Q14863412 (positive regulation of catalytic activity) positive regulation of catalytic activity
P682 biological process ... Q14864684 (fibroblast growth factor receptor signaling pathway) fibroblast growth factor receptor signaling pathway
P682 biological process ... Q14872722 (cholesterol homeostasis) cholesterol homeostasis
P682 biological process ... Q14872803 (phosphatidylinositol-3-phosphate biosynthetic process) phosphatidylinositol-3-phosphate biosynthetic process
P682 biological process ... Q14887688 (phosphatidylinositol phosphate biosynthetic process) phosphatidylinositol phosphate biosynthetic process
P682 biological process ... Q14897898 (phosphate ion homeostasis) phosphate ion homeostasis
P682 biological process ... Q14905033 (regulation of bile acid biosynthetic process) regulation of bile acid biosynthetic process
P682 biological process ... Q14905137 (negative regulation of signal transduction) negative regulation of signal transduction
P682 biological process ... Q14906203 (positive regulation of DNA biosynthetic process) positive regulation of DNA biosynthetic process
P682 biological process ... Q14906369 (regulation of lipid metabolic process) regulation of lipid metabolic process
P682 biological process ... Q14907134 (positive regulation of proteolysis) positive regulation of proteolysis
P681 cell component ... Q79927 (endoplasmic reticulum) endoplasmic reticulum
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q824237 (endosome) endosome
P681 cell component ... Q14327652 (integral component of membrane) integral component of membrane
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14645596 (extracellular region) extracellular region
P681 cell component ... Q14859540 (integral component of plasma membrane) integral component of plasma membrane
P681 cell component ... Q14860091 (transport vesicle) transport vesicle
P681 cell component ... Q14873267 (cell-cell junction) cell-cell junction
P681 cell component ... Q14877465 (receptor complex) receptor complex
P702 encoded by ... Q5446458 (FGFR4) FGFR4
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24719835 (tyrosine-protein kinase, catalytic domain) tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24738472 (tyrosine-protein kinase, active site) tyrosine-protein kinase, active site
P527 has part(s) ... Q24740842 (serine-threonine/tyrosine-protein kinase, catalytic domain) serine-threonine/tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24772334 (immunoglobulin I-set) immunoglobulin I-set
P527 has part(s) ... Q24774513 (immunoglobulin subtype 2) immunoglobulin subtype 2
P527 has part(s) ... Q24783253 (immunoglobulin-like domain) immunoglobulin-like domain
P527 has part(s) ... Q24786036 (immunoglobulin subtype) immunoglobulin subtype
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q420511 (receptor tyrosine kinase) receptor tyrosine kinase
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14819453 (heparin binding) heparin binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14911618 (fibroblast growth factor-activated receptor activity) fibroblast growth factor-activated receptor activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14863338 (protein tyrosine kinase activity) protein tyrosine kinase activity
P680 molecular function ... Q14863358 (transmembrane receptor protein tyrosine kinase activity) transmembrane receptor protein tyrosine kinase activity
P680 molecular function ... Q14864356 (transmembrane signaling receptor activity) transmembrane signaling receptor activity
P680 molecular function ... Q14866184 (fibroblast growth factor binding) fibroblast growth factor binding
P680 molecular function ... Q14872781 (1-phosphatidylinositol-3-kinase activity) 1-phosphatidylinositol-3-kinase activity
P680 molecular function ... Q14887675 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity) phosphatidylinositol-4,5-bisphosphate 3-kinase activity
P361 part of ... Q423042 (membrane protein) membrane protein
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q24780051 (fibroblast growth factor receptor family) fibroblast growth factor receptor family
P361 part of ... Q24787648 (Immunoglobulin-like fold) Immunoglobulin-like fold
P361 part of ... Q41797304 (Immunoglobulin-like domain superfamily) Immunoglobulin-like domain superfamily
P361 part of ... Q83130430 (Tyrosine-protein kinase, catalytic domain, protein family) Tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83137014 (Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family) Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q83141582 (Immunoglobulin subtype 2, protein family) Immunoglobulin subtype 2, protein family
P361 part of ... Q83145952 (Immunoglobulin I-set, protein family) Immunoglobulin I-set, protein family
P361 part of ... Q83163490 (immunoglobulin-like domain, protein family) immunoglobulin-like domain, protein family
P361 part of ... Q83165367 (immunoglobulin subtype, protein family) immunoglobulin subtype, protein family
P361 part of ... Q95352684 (Tyrosine-protein kinase, active site, protein family) Tyrosine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P129 physically interacts with ... Q15149723 (nintedanib) nintedanib
P129 physically interacts with ... Q27075200 (infigratinib) infigratinib
P129 physically interacts with ... Q27075503 (brivanib) brivanib
P129 physically interacts with ... Q27077213 (erdafitinib) erdafitinib
P129 physically interacts with ... Q27088210 (orantinib) orantinib

External Ids
P705Ensembl protein IDENSP00000424670
P705Ensembl protein IDENSP00000292408
P705Ensembl protein IDENSP00000395164
P705Ensembl protein IDENSP00000422889
P705Ensembl protein IDENSP00000424960
P705Ensembl protein IDENSP00000424905
P705Ensembl protein IDENSP00000427222
P705Ensembl protein IDENSP00000426492
P705Ensembl protein IDENSP00000377254
P705Ensembl protein IDENSP00000377259
P486MeSH descriptor IDD051499
P672MeSH tree codeD08.811.913.696.620.682.725.400.180
P672MeSH tree codeD12.776.476.568.400.180
P672MeSH tree codeD12.776.543.750.630.443
P672MeSH tree codeD12.776.543.750.750.400.370.937
P638PDB structure ID4XCU
P638PDB structure ID4QQC
P638PDB structure ID4UXQ
P638PDB structure ID4QRC
P638PDB structure ID4QQ5
P638PDB structure ID4TYJ
P638PDB structure ID4TYI
P638PDB structure ID4R6V
P638PDB structure ID4TYG
P638PDB structure ID4QQJ
P638PDB structure ID4QQT
P638PDB structure ID4TYE
P637RefSeq protein IDNP_001278909
P637RefSeq protein IDNP_001341913
P637RefSeq protein IDNP_002002
P637RefSeq protein IDNP_075252
P637RefSeq protein IDNP_998812
P7260Transporter Classification Database ID8.A.23.1.9
P2892UMLS CUIC0117719
P352UniProt protein IDP22455

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