| scholarly article | Q13442814 |
| P50 | author | Aravind L Iyer | Q4784512 |
| Lakshminarayan M. Iyer | Q57749186 | ||
| P2093 | author name string | Asba Tasneem | |
| Eric Jakobsson | |||
| P2860 | cites work | Genome trees constructed using five different approaches suggest new major bacterial clades | Q21284133 |
| Evolution of cell–cell signaling in animals: did late horizontal gene transfer from bacteria have a role? | Q22251453 | ||
| A novel class of ligand-gated ion channel is activated by Zn2+ | Q24311483 | ||
| Gapped BLAST and PSI-BLAST: a new generation of protein database search programs | Q24545170 | ||
| Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria | Q24634676 | ||
| Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins | Q24798253 | ||
| Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria | Q24803459 | ||
| Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors | Q27631812 | ||
| Structure and gating mechanism of the acetylcholine receptor pore | Q27641514 | ||
| Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation | Q42612943 | ||
| Chlamydial homologues of the MACPF (MAC/perforin) domain | Q43427674 | ||
| Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance | Q43509560 | ||
| Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. | Q43803635 | ||
| Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits. | Q44038158 | ||
| Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge? | Q44463600 | ||
| Weighted neighbor joining: a likelihood-based approach to distance-based phylogeny reconstruction | Q44809305 | ||
| Phylogenomic analysis and evolution of the potassium channel gene family. | Q52642500 | ||
| Exploitation of gene context | Q55136027 | ||
| On the maximum likelihood method in molecular phylogenetics | Q67989380 | ||
| Formation of mixed glycine and GABAergic synapses in cultured spinal cord neurons | Q73167497 | ||
| The genetics of disulfide bond metabolism | Q77936221 | ||
| TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing | Q27860512 | ||
| MRBAYES: Bayesian inference of phylogenetic trees | Q27860538 | ||
| Improved prediction of signal peptides: SignalP 3.0 | Q27860548 | ||
| SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling | Q27860614 | ||
| Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes | Q27860838 | ||
| T-Coffee: A novel method for fast and accurate multiple sequence alignment | Q27860999 | ||
| A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood | Q27861000 | ||
| Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine | Q28216894 | ||
| Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins | Q28581418 | ||
| Application of multiple sequence alignment profiles to improve protein secondary structure prediction | Q29614377 | ||
| TopPred II: an improved software for membrane protein structure predictions | Q29618438 | ||
| Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods | Q29618948 | ||
| Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer | Q30715471 | ||
| Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors | Q30965285 | ||
| Evolutionary connections between bacterial and eukaryotic signaling systems: a genomic perspective | Q31015680 | ||
| Plasmodium biology: genomic gleanings | Q31034559 | ||
| The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor | Q31967454 | ||
| Gene and context: integrative approaches to genome analysis | Q33928603 | ||
| Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study. | Q34004292 | ||
| Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites | Q34017183 | ||
| Formation and transfer of disulphide bonds in living cells | Q34157680 | ||
| Coupling of agonist binding to channel gating in the GABA(A) receptor | Q34170761 | ||
| M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective | Q34173431 | ||
| Structure and function of the glycine receptor and related nicotinicoid receptors | Q34306215 | ||
| Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells | Q34307351 | ||
| The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. | Q34322334 | ||
| PHD--an automatic mail server for protein secondary structure prediction | Q34341867 | ||
| Sequence and function of the two P domain potassium channels: implications of an emerging superfamily | Q34455956 | ||
| A novel mutation (R218Q) at the boundary between the N-terminal and the first transmembrane domain of the glycine receptor in a case of sporadic hyperekplexia | Q35442415 | ||
| Cys-loop receptors: new twists and turns | Q35785730 | ||
| The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus | Q36987517 | ||
| SEALS: a system for easy analysis of lots of sequences. | Q38457841 | ||
| LGICdb: the ligand-gated ion channel database | Q38660927 | ||
| Evolutionary history of the ligand-gated ion-channel superfamily of receptors | Q40527814 | ||
| Intracellular cross talk and physical interaction between two classes of neurotransmitter-gated channels. | Q40668971 | ||
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily | Q40794433 | ||
| The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins | Q41074853 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | R4 | |
| P577 | publication date | 2005-01-01 | |
| P1433 | published in | Genome Biology | Q5533480 |
| P1476 | title | Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels | |
| P478 | volume | 6 |
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| Q48075837 | A novel member of the ligand-gated chloride channel gene family from Haemonchus contortus |
| Q52770038 | A potentially novel nicotinic receptor in Aplysia neuroendocrine cells. |
| Q28239688 | A predicted binding site for cholesterol on the GABAA receptor |
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| Q38039375 | An outline of desensitization in pentameric ligand-gated ion channel receptors. |
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| Q33468499 | Apprehending multicellularity: regulatory networks, genomics, and evolution |
| Q40897947 | Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner. |
| Q37649162 | Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues. |
| Q34253279 | Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states |
| Q34008315 | Chemical and genetic engineering of selective ion channel-ligand interactions |
| Q37401733 | Conduits of life's spark: a perspective on ion channel research since the birth of neuron |
| Q38201039 | Conformational sampling in template-free protein loop structure modeling: an overview |
| Q42404119 | Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC) |
| Q39113567 | Critical importance of RAB proteins for synaptic function. |
| Q27644591 | Crystal structure of a human GABAA receptor |
| Q53831585 | Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation. |
| Q39949261 | Cys-loop receptor channel blockers also block GLIC. |
| Q30377929 | Deep evolutionary origins of neurobiology: Turning the essence of 'neural' upside-down. |
| Q42182878 | Desensitization mechanism in prokaryotic ligand-gated ion channel |
| Q37237079 | Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site |
| Q38908349 | Direct interaction of the resistance to inhibitors of cholinesterase type 3 protein with the serotonin receptor type 3A intracellular domain |
| Q57292248 | Direct visualization of ion-channel gating in a native environment |
| Q91844566 | Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors |
| Q33719563 | Domain-Based Identification and Analysis of Glutamate Receptor Ion Channels and Their Relatives in Prokaryotes |
| Q38464421 | EPR Studies of Gating Mechanisms in Ion Channels |
| Q24618824 | End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease |
| Q35032615 | Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit |
| Q35266466 | Engineering a prokaryotic Cys-loop receptor with a third functional domain |
| Q83061559 | Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria |
| Q34518637 | Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors |
| Q26314507 | Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster |
| Q36912503 | Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors |
| Q36428969 | From molecule to malady |
| Q37954330 | From toxins targeting ligand gated ion channels to therapeutic molecules |
| Q35554776 | Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors |
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| Q35123262 | Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family |
| Q37252068 | Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels |
| Q27680479 | Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography |
| Q48218876 | Genome scale identification, structural analysis, and classification of periplasmic binding proteins from Mycobacterium tuberculosis |
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| Q35838845 | Intramembrane proton binding site linked to activation of bacterial pentameric ion channel |
| Q33622066 | Ion conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures |
| Q31060057 | Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization |
| Q27670592 | Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC |
| Q35048943 | Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel |
| Q38974419 | Mechanism of Allosteric Modulation of the Cys-loop Receptors |
| Q34441737 | Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. |
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