Role of cytochrome P450 in drug interactions

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Role of cytochrome P450 in drug interactions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814
retracted paperQ45182324

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P6179Dimensions Publication ID1043771492
P356DOI10.1186/1743-7075-5-27
P3181OpenCitations bibliographic resource ID3189411
P932PMC publication ID2584094
P698PubMed publication ID18928560
P5875ResearchGate publication ID23392244

P2093author name stringZakia Bibi
P2860cites workPharmacokinetic Drug Interactions with Oral ContraceptivesQ22305837
Cytochrome P4502C9: an enzyme of major importance in human drug metabolismQ24683497
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]Q28115162
Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiaeQ28332545
Torsades de pointes occurring in association with terfenadine useQ28334377
Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intakeQ45215557
Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juiceQ48809052
Gender does not affect the degree of induction of tirilazad clearance by phenobarbital.Q51018598
Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin.Q51530884
Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin.Q51577607
Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam.Q51578907
Effect of omeprazole on diazepam disposition in the rat: in vitro and in vivo studies.Q51590352
The erythromycin breath test predicts the clearance of midazolam.Q51614889
Mechanisms of ethanol-drug-nutrition interactions.Q51646112
Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.Q51743867
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.Q51818926
Drug interactions between cyclosporine and rifampicin, erythromycin, and azoles in kidney recipients with opportunistic infections.Q53809592
Ethanol enhances the hemodynamic effects of felodipine.Q54339719
Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.Q55060683
Loss of analgesic effect of morphine due to coadministration of rifampinQ56832359
Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic ActivitiesQ59153257
Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolismQ61794937
Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary cultureQ67532013
Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycinQ68045940
Differential inhibition of individual human liver cytochromes P-450 by cimetidineQ68063454
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodeneQ68397000
The microsomal ethanol oxidizing system and its interaction with other drugs, carcinogens, and vitaminsQ68766357
Erythromycin-cyclosporin interactionQ68883421
Clinical significance of the sparteine/debrisoquine oxidation polymorphismQ69373690
Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequencesQ70591704
1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomesQ70639652
Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringinQ70766724
Phenytoin toxicity due to concomitant antituberculosis therapyQ70990937
Severe carbamazepine toxicity induced by concurrent erythromycin therapyQ71458023
Interactions and drug-metabolizing enzymesQ71550886
Differential induction of prehepatic and hepatic metabolism of verapamil by rifampinQ71650801
The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolismQ71731666
Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomesQ71812126
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slicesQ71812186
Ethanol and acetaldehyde metabolism: past, present, and futureQ71841556
Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance: 1996 updateQ71841578
Diltiazem does not always increase blood cyclosporin concentrationQ71850230
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylationQ72223807
Pharmacokinetics of desipramine coadministered with sertraline or fluoxetineQ72467721
Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylationQ72545136
Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardiaQ72564540
Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampinQ72693322
Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activityQ72703173
Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequencesQ72793332
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugsQ73064221
Comparison of the effects of cimetidine and ranitidine on the pharmacokinetics of disopyramide in manQ73947667
Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutinQ73949924
Metabolic drug interactions with selective serotonin reuptake inhibitor (SSRI) antidepressantsQ74525214
Pharmacokinetic drug interactions with anti-ulcer drugsQ77306655
Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450sQ28610006
Interactions Between Antipsychotic and Antihypertensive DrugsQ33173690
Defective N-oxidation of sparteine in man: A new pharmacogenetic defectQ34053243
Polymorphic hydroxylation of Debrisoquine in man.Q34057031
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoinQ34241704
Severe acetaminophen toxicity in a patient receiving isoniazidQ34260561
Erythromycin-induced carbamazepine toxicity: a continuing problemQ34316480
A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smokingQ34418056
Drug interaction between propafenone and metoprololQ34420988
The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodiesQ34447852
Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidenceQ34452996
Update: clinically significant cytochrome P-450 drug interactionsQ34456931
Grape fruit juice-drug interactionsQ34479869
Effect of smoking on theophylline dispositionQ34534103
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazoleQ34579242
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populationsQ34695612
Clinically important drug interactions with anticoagulants. An updateQ34734558
Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2.Q34735311
Drug interactions with grapefruit juiceQ34742609
Clinical singgnificance of interactions with antifungal agentsQ35225764
Pharmacokinetic drug interactions of macrolidesQ35759081
Characterization of human cytochrome P450 enzymesQ35890693
Pharmacokinetic drug interactions with rifampicinQ35981437
Diazepam-omeprazole inhibition interaction: an in vitro investigation using human liver microsomesQ36093758
Diltiazem-cyclosporin pharmacokinetic interaction--dose-response relationshipQ36094166
Molecular genetics of the debrisoquin-sparteine polymorphismQ36522041
Omeprazole drug interaction studiesQ36890310
Self-catalyzed destruction of cytochrome P-450: covalent binding of ethynyl sterols to prosthetic hemeQ37314759
Alcohol and drug interactionsQ37610909
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclatureQ37632095
Genetic polymorphism of sparteine/debrisoquine oxidation: a reappraisalQ37782957
The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanismsQ37911387
The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspectsQ37924766
Selective Serotonin Reuptake Inhibitors: Pharmacologic Profiles and Potential Therapeutic DistinctionsQ38573611
Genetic polymorphism of S-mephenytoin hydroxylationQ38692055
Pharmacokinetic interactions of cimetidine 1987.Q39662361
Role of tobacco smoking in pharmacokineticsQ39723934
Pharmacokinetic interaction between rifampin and zidovudineQ39866285
Drug interactions with cimetidineQ40329702
P450 inhibitors of use in medical treatment: focus on mechanisms of actionQ40379770
Macrolide antibacterials. Drug interactions of clinical significanceQ40423079
Recent Advances: the Cytochrome P450 EnzymesQ40475823
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclatureQ40484461
Pharmacogenetics and drug metabolism of newer antidepressant agents.Q40564994
Clinically significant drug interactions with antituberculosis agentsQ40587502
Pharmacokinetic drug interactions with antimicrobial agentsQ40720380
Hypertension and endstage renal diseaseQ40757473
Drug interactions of clinical significance with opioid analgesicsQ40895607
Quinolones: a practical review of clinical uses, dosing considerations, and drug interactions.Q40932838
Cytochrome P450 monooxygenases and interactions of psychotropic drugs: a five-year updateQ40949311
Cigarette smoking and clinically significant drug interactionsQ40952943
Newer antidepressants and the cytochrome P450 systemQ40976263
Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system.Q41027208
The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactionsQ41030442
Drug interactions with antiviral drugsQ41066477
The emerging role of cytochrome P450 3A in psychopharmacologyQ41071277
Cytochrome P450 isozymes and antiepileptic drug interactionsQ41112031
Drug interactions with azithromycin and the macrolides: an overviewQ41119734
Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazoleQ41128197
Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6.Q41143923
Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.Q41143946
Drug interactions and the cytochrome P450 system. The role of cytochrome P450 2C19.Q41143951
Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.Q41173261
New applications of bacterial systems to problems in toxicology.Q41188301
Pharmacokinetic interactions of the new antiepileptic drugsQ41192725
Clinically significant drug interactions with cyclosporin. An updateQ41201529
Pharmacokinetics and drug interactions: update for new antipsychoticsQ41240756
Susceptibility to alcohol-related liver injuryQ41281855
Drug interactions of macrolides: emphasis on dirithromycinQ41380268
Drug interactions with proton pump inhibitorsQ41428950
Clinically significant drug interactions with new immunosuppressive agentsQ41440255
Drug-mediated inactivation of cytochrome P450.Q41555359
Pharmacokinetic interactions between alcohol and other drugsQ41565312
A review of enzyme induction of warfarin metabolism with recommendations for patient managementQ41607931
Role of cytochrome P450 enzymes in drug-drug interactions.Q41619409
Cytochrome P-450 3A: interactions with dermatologic therapiesQ41641136
Drug interactions in human neuropathic pain pharmacotherapyQ41670759
Drug interactions of clinical significance with selective serotonin reuptake inhibitorsQ41682186
Interactions between tacrolimus and antimicrobial agents.Q41683257
Cytochrome P450: new nomenclature and clinical implicationsQ41691948
In vitro approaches to predicting drug interactions in vivo.Q41692688
Erythromycin: drug interactionsQ41704719
Systemic antifungal agents. Drug interactions of clinical significanceQ41725883
Effects of H2-receptor antagonists on ethanol metabolism in Japanese volunteersQ42122933
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.Q42226492
Clinically relevant drug-drug interactions in oncologyQ42284655
Metabolic interactions of the proton-pump inhibitors lansoprazole, omeprazole and pantoprazole with other drugsQ42552393
Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamilyQ43422277
Expression of cytochrome P-450 enzymes in cultured human hepatocytesQ44049518
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.Q44898021
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthuman nutritionQ2602563
P304page(s)27
P577publication date2008-01-01
P1433published inNutrition and MetabolismQ15752980
P1476titleRole of cytochrome P450 in drug interactions
P478volume5

Reverse relations

cites work (P2860)
Q46091244A phase I open-label study to investigate the potential drug-drug interaction between single-dose dacomitinib and steady-state paroxetine in healthy volunteers.
Q53801573A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats.
Q64119158Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid
Q50281847CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem
Q33768358Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.
Q92054763Curcumin effect on cancer cells' multidrug resistance: An update
Q92552975Cytochrome P450 2A6 and 2B6 polymorphisms and smoking cessation success in patients treated with varenicline
Q37442618Development of a High-Resolution Melting Analysis Method for CYP2C19*17 Genotyping in Healthy Volunteers
Q97588879Development of a metabolically stable topoisomerase I poison as anticancer agent
Q39501603Distribution of CYP2C19*2 and CYP2C19*3 polymorphisms in Venezuelan populations with different admixture
Q28475862Does the clock make the poison? Circadian variation in response to pesticides
Q85979393Effect of ciprofloxacin and grapefruit juice on oral pharmacokinetics of riluzole in Wistar rats
Q46930998Effect of commonly used organic solvents on aldehyde oxidase-mediated vanillin, phthalazine and methotrexate oxidation in human, rat and mouse liver subcellular fractions
Q86006407Effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) on the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism, and differences in the action of parent BDE-47 and its hydroxylated metabolites, 5-OH-BDE-47 and 6-OH-BDE47, on ste
Q54361453Effects of enrofloxacin on cytochromes P4501A and P4503A in Carassius auratus gibelio (crucian carp).
Q84607160Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats
Q84483077Effects of fluoroquinolones on CYP4501A and 3A in male broilers
Q39178477Effects of norfloxacin on hepatic genes expression of P450 isoforms (CYP1A and CYP3A), GST and P-glycoprotein (P-gp) in Swordtail fish (Xiphophorus Helleri).
Q57871328Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain
Q38862327Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics
Q85553965Ephedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats
Q42233351Even 'safe' medications need to be administered with care
Q82466277Exploration of the binding of curcumin analogues to human P450 2C9 based on docking and molecular dynamics simulation
Q82680399Exploration of the binding of proton pump inhibitors to human P450 2C9 based on docking and molecular dynamics simulation
Q87211259Expression of selected cytochrome P450 isoforms and of cooperating enzymes in colorectal tissues in selected pathological conditions
Q40226025Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents Dengue 2 viral assembly
Q90749633Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats
Q98238804Gold Nanoparticles Perturb Drug-Metabolizing Enzymes and Antioxidants in the Livers of Male Rats: Potential Impact on Drug Interactions
Q92890984Guidance for Rifampin and Midazolam Dosing Protocols To Study Intestinal and Hepatic Cytochrome P450 (CYP) 3A4 Induction and De-induction
Q35648962Hepatotoxicity of molecular targeted therapy
Q28240999Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders
Q101117560Impact of Transgenic Arabidopsis thaliana Plants on Herbicide Isoproturon Phytoremediation through Expressing Human Cytochrome P450-1A2
Q122397436In silico screening for potential inhibitors from the phytocompounds of Carica papaya against Zika virus NS5 protein
Q87237318In vitro assessment of CYP1A2 and 2C9 inhibition potential of Withania somnifera and Centella asiatica in human liver microsomes
Q45306265Incorporating psychiatric pharmacogenetics into family practice
Q53735385Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy.
Q42672906Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits
Q50850212Influence of tobacco smoke exposure on pharmacokinetics of ethyl alcohol in alcohol preferring and non-preferring rats.
Q35579544Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions
Q86629675Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship
Q47682758In vitro and in vivo cytochrome P450 3A enzyme inhibition by Aframomum melegueta and Denniettia tripetala extracts
Q60240219Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements
Q39534069Ketoconazole, a cytochrome P(450) inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis
Q58557345Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer's Disease: A Computational Study
Q46587852Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305.
Q39000644Microsomal cytochrome P450 as a target for drug discovery and repurposing
Q64099168Network-based prediction of drug combinations
Q38053461Pharmacokinetics of macrolides in foals
Q38107023Pharmacophore modeling for ADME.
Q86314907Phenytoin-rifampin drug interaction in a hypoalbuminemic, renal failure patient: a complex clinical case
Q112579841Potential bioactive compounds as SARS-CoV-2 inhibitors from extracts of the marine red alga Halymenia durvillei (Rhodophyta) - A computational study
Q51738081Production of a New Plant-Based Milk from Adenanthera pavonina Seed and Evaluation of Its Nutritional and Health Benefits.
Q42643524Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
Q45157771Quantitatively interpreted enhanced inhibition of cytochrome P450s by heteroaromatic rings containing nitrogen
Q41955577Retraction: Role of cytochrome P450 in drug interactions
Q48313390Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage.
Q46777015Selected Food/Herb-Drug Interactions: Mechanisms and Clinical Relevance.
Q91974324Simultaneous Pharmacokinetics Estimation of Nateglinide and Pioglitazone by RP-HPLC: Computational Study to Unlock the Synergism
Q35185164Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis
Q44049123Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties
Q49248994The Role of Cytochromes P450 in Infection
Q55426998The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo.
Q38849978The pathogenesis of drug-induced liver injury
Q47598246The pharmacokinetics of DPH after the administration of a single intravenous or intramuscular dose in healthy dogs
Q41675649Traditional Herbal Formulas to as Treatments for Musculoskeletal Disorders: Their Inhibitory Effects on the Activities of Human Microsomal Cytochrome P450s and UDP-glucuronosyltransferases
Q88432627Transmucosal delivery of melatonin-encapsulated niosomes in a mucoadhesive gel
Q38250391Understanding and managing oral bioavailability: physiological concepts and patents
Q46430453Utility of a column-switching LC/MS/MS method in cytochrome P450 inhibition assays using human liver microsomes
Q96603404[BOMBAX COSTATUM EXTRACT ABROGATES PIROXICAM-MEDIATED HEPATIC AND GASTRIC TOXICITIES IN RATS]
Q87014352[Mechanism of hepatoprotective action of methionine and composition "Metovitan" against a background of antituberculosis drug administration to rats]
Q54624734[Risk of pharmacological interactions due to the co-administration of statins and cytochrome P450 isoenzyme 3A4-metabolized drugs: multicentre, crossover study].

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