Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial

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Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1028706706
P356DOI10.1186/1479-5876-12-38
P932PMC publication ID3923730
P698PubMed publication ID24507657
P5875ResearchGate publication ID260129345

P2093author name stringJean-Louis Abitbol
Patrick Berna
Sophie Schaller
Alain Berdeaux
Jean Afxantidis
Magali Michaud
Marcel Culcasi
Sylvia Pietri
Yves Donazzolo
Didier Morin
Stéphanie Paradis
Hidayat Rahmouni
Corinne Chaimbault
Mathilde Latreille
Sophie Le Lamer
Rebacca M Pruss
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The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transportQ41953172
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TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition.Q43136849
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Rationale and Design of the MITOCARE Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous CoroQ57572076
Lethal reperfusion injury in acute myocardial infarction: facts and unresolved issues.Q64970631
Ascorbyl free radical as a reliable indicator of free-radical-mediated myocardial ischemic and post-ischemic injury. A real-time continuous-flow ESR studyQ68487724
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Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reactionQ74332512
New perspectives on the cardioprotective phosphonate effect of the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: an hemodynamic and 31P NMR study in rat heartsQ78115602
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Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisomeQ84444951
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphase I clinical trialQ5452194
myocardial infarctionQ12152
P304page(s)38
P577publication date2014-01-01
P1433published inJournal of Translational MedicineQ15716664
P1476titleTranslation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial
P478volume12

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cites work (P2860)
Q50560471Administration of the Mitochondrial Permeability Transition Pore Inhibitor, TRO40303, prior to Primary Percutaneous Coronary Intervention, Does Not Affect the Levels of Pro-Inflammatory Cytokines or Acute-Phase Proteins.
Q34056025Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons
Q54325677Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results.
Q53836881Estrogen receptor beta modulates permeability transition in brain mitochondria.
Q30491901Exosomes From Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/β-Catenin Signaling Pathway
Q36203942Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria
Q64886537Mitochondrial Membrane Permeability Inhibitors in Acute Myocardial Infarction: Still Awaiting Translation.
Q92356830New insights into acute pancreatitis
Q91860378Pharmacology of mitochondrial permeability transition pore inhibitors
Q49771122TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester-Induced Mitochondrial Injury and Necrotic Cell Death
Q41359580TRO40303, a mitochondrial-targeted cytoprotective compound, provides protection in hepatitis models
Q91276580Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
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