Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer

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Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer is …
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P6179Dimensions Publication ID1042176662
P356DOI10.1186/1476-4598-7-83
P3181OpenCitations bibliographic resource ID4771095
P932PMC publication ID2613402
P698PubMed publication ID18990230
P5875ResearchGate publication ID23457434

P50authorRuth Knüchel-ClarkeQ2177653
Edgar DahlQ30004394
Jürgen VeeckQ30004422
Erik NoetzelQ59685487
Arndt HartmannQ89782316
Nuran BektasQ117248893
P2093author name stringEdgar Jost
P2860cites workSecreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signalingQ22011203
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Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesisQ28237570
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancerQ28251800
Methylation changes in faecal DNA: a marker for colorectal cancer screening?Q28257322
Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancerQ28260824
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Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosisQ28294866
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Gene silencing in cancer in association with promoter hypermethylationQ29617274
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Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancerQ33248745
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MGMT promoter methylation and field defect in sporadic colorectal cancer.Q34452509
Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosisQ34763742
Secreted Frizzled-related proteins: searching for relationships and patternsQ34811402
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progressionQ35679187
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Method for grading breast cancerQ37232617
Comparison of features of human breast cancer cell lines and their corresponding tumorsQ38469971
The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylationQ40102564
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Biological differences among MCF-7 human breast cancer cell lines from different laboratoriesQ42660326
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignanciesQ44646952
DNA methylation analysis by MethyLight technologyQ46134861
Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagusQ46433748
Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA.Q46696080
CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemiaQ46902022
beta-Catenin and p53 analyses of a breast carcinoma tissue microarray.Q47616131
Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands.Q48004390
Secreted frizzled related protein 2 (sFRP2) decreases susceptibility to UV-induced apoptosis in primary culture of canine mammary gland tumors by NF-kappaB activation or JNK suppression.Q51798920
Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma.Q53335862
High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.Q53349508
Mapping Geographic Zones of Cancer Risk with Epigenetic Biomarkers in Normal Breast TissueQ57591075
Cyclin D1 protein expression and function in human breast cancerQ58883578
Epigenetic Inactivation of SFRP Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder CancerQ59313166
[Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]Q68175965
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancersQ71729088
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomasQ71804951
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cellsQ72386166
Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [seecomments]Q73368658
Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancerQ74088944
Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtypeQ78532817
SFRP2 methylation in fecal DNA--a marker for colorectal polypsQ80637295
Methylation-specific polymerase chain reactionQ81872282
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohortQ82843914
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
hypermethylationQ106875739
P304page(s)83
P577publication date2008-01-01
P1433published inMolecular CancerQ15724585
P1476titlePromoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer
P478volume7