Orthopoxvirus genes that mediate disease virulence and host tropism

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Orthopoxvirus genes that mediate disease virulence and host tropism is …
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scholarly articleQ13442814

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P356DOI10.1155/2012/524743
P932PMC publication ID3413996
P698PubMed publication ID22899927
P5875ResearchGate publication ID230686344

P50authorSergey ShchelkunovQ4528657
P2860cites workA new inhibitor of apoptosis from vaccinia virus and eukaryotesQ21131614
The F-box protein family.Q21194893
Cullin-RING ubiquitin ligases: global regulation and activation cyclesQ21203558
The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein BaxQ24310440
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family proteinQ24319056
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene familyQ24336422
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7Q24338222
Vaccinia virus DNA replication occurs in endoplasmic reticulum-enclosed cytoplasmic mini-nucleiQ24555699
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligaseQ24558689
cDNA sequence for human erythrocyte ankyrinQ24558769
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinaseQ24561643
Systematic analysis and nomenclature of mammalian F-box proteinsQ24561715
Strategies and mechanisms for host and pathogen survival in acute and persistent viral infectionsQ24563791
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Innate immune sensing of DNA virusesQ24626598
Poxvirus pathogenesisQ24634729
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanismsQ24642586
Origin and function of ubiquitin-like proteinsQ24651141
Sequence and structural analysis of BTB domain proteinsQ24812693
Structure and Function of A41, a Vaccinia Virus Chemokine Binding ProteinQ27649568
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than ApoptosisQ27651621
Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to VirulenceQ27676390
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
Ectromelia virus encodes a novel family of F-box proteins that interact with the SCF complexQ39953355
Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response.Q40122897
Properties of the recombinant TNF-binding proteins from variola, monkeypox, and cowpox viruses are different.Q40214772
Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model.Q40280943
Role of mitochondria in apoptosis induced by the 2-5A system and mechanisms involvedQ40305867
Vaccinia virus-induced microtubule-dependent cellular rearrangementsQ40312383
Functional organization of variola major and vaccinia virus genomesQ40372624
Natural human infections with Vaccinia virus during bovine vaccinia outbreaks.Q40396299
Effects of deletions of kelch-like genes on cowpox virus biological propertiesQ40436338
The poxvirus p28 virulence factor is an E3 ubiquitin ligaseQ40501664
An evolutionary and functional approach to the TNF receptor/ligand familyQ40699318
Tumor necrosis factor: a pleiotropic cytokine and therapeutic targetQ40759728
Alastrim smallpox variola minor virus genome DNA sequencesQ40905542
One step ahead of the game: viral immunomodulatory moleculesQ41039669
Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.Q41047354
Species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteinsQ41349480
Microorganisms and their interaction with the immune system.Q41614591
Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinaseQ41659163
DNA sequence of the gene encoding a major secreted protein of vaccinia virus, strain ListerQ41722728
Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infectionQ42023832
Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replicationQ42117156
Orthopoxviruses require a functional ubiquitin-proteasome system for productive replicationQ42122542
Central modules of the vaccinia virus complement control protein are not in extensive contactQ42158637
Encoding of a homolog of the IFN-gamma receptor by myxoma virusQ42605801
Nucleotide sequence of XhoI O fragment of ectromelia virus DNA reveals significant differences from vaccinia virusQ42610824
The genomic sequence of ectromelia virus, the causative agent of mousepoxQ42615527
Deletion of 55 open reading frames from the termini of vaccinia virusQ42626327
Terminal region sequence variations in variola virus DNA.Q42631935
Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus AnkaraQ42637410
Species-specific differences in the structure of orthopoxvirus complement-binding proteinQ42662567
Human monkeypox and smallpox viruses: genomic comparison.Q42664957
The genomic sequence analysis of the left and right species-specific terminal region of a cowpox virus strain reveals unique sequences and a cluster of intact ORFs for immunomodulatory and host range proteinsQ42676735
Analysis of the monkeypox virus genomeQ42679073
Comparison of the genome DNA sequences of Bangladesh-1975 and India-1967 variola virusesQ42679832
Analysis of the nucleotide sequence of 53 kbp from the right terminus of the genome of variola major virus strain India-1967.Q42689843
A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary historyQ42717454
Animal poxviruses transmitted from cat to man: current event with lethal endQ43208749
Cowpox infection causing a generalized eruption in a patient with atopic dermatitisQ43213037
A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response.Q43587591
Genes of variola and vaccinia viruses necessary to overcome the host protective mechanismsQ43604360
Species-specific differences in organization of orthopoxvirus kelch-like proteinsQ43838742
Investigation of the impact of cowpox virus BTB/kelch gene deletion on some characteristics of infection in vitroQ43915406
F-box-like domains are present in most poxvirus ankyrin repeat proteinsQ43986616
Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virusQ45034493
The time scale in poxvirus evolutionQ45207603
Cowpox virus evades CTL recognition and inhibits the intracellular transport of MHC class I moleculesQ45408166
The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal modelQ45722229
The cowpox virus-encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory proteinQ45763563
Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alphaQ45768255
Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificityQ45785576
Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinaseQ45795607
Does the cytoskeleton play a significant role in animal virus replication?Q45798533
Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferonQ45859752
A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infectionQ45872018
Transcription of both DNA strands of vaccinia virus genome in vivoQ45890507
Novel complement inhibitorsQ47771165
Molecular mimicry of the inflammation modulatory proteins (IMPs) of poxviruses: evasion of the inflammatory response to preserve viral habitatQ47841519
Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor virusesQ48065597
Two types of deletions in orthopoxvirus genomesQ48075345
Ankyrin-like proteins of variola and vaccinia virusesQ48129119
A truncated two-alpha-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex.Q51783355
A poxvirus protein with a RING zinc finger motif is of crucial importance for virulence.Q52515649
[Orthopoxvirus genes for kelch-like proteins. III. Construction of mousepox (ectromelia) virus variants with targeted gene deletions]Q53875406
Comparative assessment of the properties of orthopoxviral soluble receptors for tumor necrosis factor.Q54518968
Molecular mimicry and the generation of host defense protein diversityQ70623063
[Immunomodulatory proteins of orthopoxviruses]Q73096867
Interleukin-18: a novel cytokine that augments both innate and acquired immunityQ77355821
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targetingQ79828292
Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T-cell priming, and peptide association with MHC class II.Q39753158
Inhibition of type III interferon activity by orthopoxvirus immunomodulatory proteinsQ39758342
The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.Q39761790
RING finger proteins: mediators of ubiquitin ligase activityQ28139717
Buffalopox: an emerging and re-emerging zoonosisQ28240313
Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteinsQ28297889
Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulenceQ28300302
Shared principles in NF-kappaB signalingQ29547234
ChemokinesQ29616435
One more piece in the VACV ecological puzzle: could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil?Q33348061
Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxvirusesQ33447166
The inflammasomes.Q33521252
IL-1beta processing in host defense: beyond the inflammasomesQ33535878
Vaccinia virus protein F1L is a caspase-9 inhibitorQ33648434
SECRET domain of variola virus CrmB protein can be a member of poxviral type II chemokine-binding proteins familyQ33729691
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domainQ33781751
Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox virusesQ33782567
Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: a novel [...]Q33805943
CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses.Q33834737
Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse modelQ33835582
Viral mechanisms of immune evasionQ34011092
Variola virus immune evasion design: expression of a highly efficient inhibitor of human complementQ34066011
Emergence and reemergence of smallpox: the need for development of a new generation smallpox vaccine.Q34107071
Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of CongoQ34136736
Complement and viral pathogenesisQ34162421
Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteinsQ34168584
Poxviruses and immune evasionQ34172411
Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons.Q34328870
Vaccinia virus proteome: identification of proteins in vaccinia virus intracellular mature virion particlesQ34434835
Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptorsQ34441628
Cowpox with severe generalized eruption, FinlandQ34560041
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virusQ34596242
How long ago did smallpox virus emerge?Q34613410
Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switchingQ34810232
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.Q35740993
Ectromelia virus RING finger protein is localized in virus factories and is required for virus replication in macrophagesQ35840927
Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificityQ35843985
A third distinct tumor necrosis factor receptor of orthopoxvirusesQ36010238
Poxvirus-induced alteration of arachidonate metabolismQ36147156
Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2DQ36229447
Ectromelia virus: the causative agent of mousepoxQ36269022
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defenseQ36370571
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulenceQ36403362
An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain.Q36424497
The ubiquitin-proteasome pathway in viral infectionsQ36538328
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.Q36643929
Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activitiesQ36656593
Deubiquitination in virus infectionQ36732782
Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligasesQ36740202
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexesQ36825432
The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradationQ37010771
Immune evasion of natural killer cells by virusesQ37060710
Cowpox virus infection: an emerging health threatQ37100940
Inhibition of the ubiquitin-proteasome system prevents vaccinia virus DNA replication and expression of intermediate and late genesQ37110640
Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range functionQ37157179
Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.Q37191825
Cowpox virus transmission from pet rats to humans, FranceQ37203679
Cowpox virus transmission from pet rats to humans, GermanyQ37203719
The orthopoxvirus 68-kilodalton ankyrin-like protein is essential for DNA replication and complete gene expression of modified vaccinia virus Ankara in nonpermissive human and murine cells.Q37204575
Sensing pathogens and danger signals by the inflammasomeQ37240692
Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principlesQ37279489
A mechanism for the inhibition of fever by a virusQ37307863
Manipulation of the ubiquitin-proteasome pathway by small DNA tumor virusesQ37327240
Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathwaysQ37378752
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.Q37421291
Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cellsQ37470752
Inflammasomes bridge signaling between pathogen identification and the immune responseQ37655058
Animal Models ofOrthopoxvirusInfectionQ37777545
Interaction of orthopoxviruses with the cellular ubiquitin-ligase system.Q37779516
Vaccinia virus A35R inhibits MHC class II antigen presentationQ39390434
Molecular and cellular biology of intermediate filamentsQ39532153
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectvirulenceQ1460232
host tropismQ1536273
P304page(s)524743
P577publication date2012-07-30
P1433published inAdvances in virologyQ26842424
P1476titleOrthopoxvirus genes that mediate disease virulence and host tropism
P478volume2012

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