Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

scientific article

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1026170473
P356DOI10.1038/13821
P8608Fatcat IDrelease_ccrsgnyh2jdofpjakxkzvk4qb4
P698PubMed publication ID10508516

P2093author name stringC Heyting
H H Offenberg
M Eijpe
M van Aalderen
W Goedecke
P2860cites workThe transcriptional program of sporulation in budding yeastQ27938344
Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiaeQ28306536
SCP2: a major protein component of the axial elements of synaptonemal complexes of the ratQ28583161
Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cellsQ29617437
An atypical topoisomerase II from Archaea with implications for meiotic recombinationQ29618230
The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genesQ36645944
Two types of RAS mutants that dominantly interfere with activators of RAS.Q36654269
mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosisQ37367245
A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosisQ39631261
Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombinationQ39716405
Molecular and biochemical characterization of xrs mutants defective in Ku80.Q40021061
In situ visualization of DNA double-strand break repair in human fibroblastsQ41045622
Double-strand breaks at an initiation site for meiotic gene conversionQ59068287
DNA end-joining: from yeast to manQ63362924
Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosisQ64389750
Spermatogonial stem-cell renewal in the mouseQ71773555
The many interfaces of Mre11Q77654630
DNA end-joining catalyzed by human cell-free extractsQ22008041
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaksQ24311761
Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repairQ24316169
Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiaeQ24649768
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein familyQ27930009
Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombinationQ27930776
Zip2, a meiosis-specific protein required for the initiation of chromosome synapsisQ27934770
Complex formation and functional versatility of Mre11 of budding yeast in recombinationQ27935743
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeastQ27936427
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenanceQ27937328
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectX-ray repair cross complementing 6Q21116645
P304page(s)194-8
P577publication date1999-10-01
P1433published inNature GeneticsQ976454
P1476titleMre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
P478volume23

Reverse relations

cites work (P2860)
Q35762470A means to a DNA end: the many roles of Ku.
Q33841787A mechanism of palindromic gene amplification in Saccharomyces cerevisiae
Q40575476Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions
Q27324477COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining
Q39707017Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells
Q50671994Cellular responses to ionizing radiation damage.
Q92136735Challenges and Perspectives in Homology-Directed Gene Targeting in Monocot Plants
Q34173678Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes
Q43102476Chlorine ions but not sodium ions alter genome stability of Arabidopsis thaliana
Q35029335Choosing the right path: does DNA-PK help make the decision?
Q34016558Chromatin organization and remodeling of interstitial telomeric sites during meiosis in the Mongolian gerbil (Meriones unguiculatus).
Q37638191Collaboration and competition between DNA double‐strand break repair pathways
Q27324367Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance
Q34506211DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids
Q37063328DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis
Q40745510DNA damage and repair in lymphoblastoid cell lines from normal donors and fragile X syndrome patients
Q39745562DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells.
Q35608458DNA damage response and repair: insights into strategies for radiation sensitization of gliomas
Q51971590DNA damage response during chromatin remodeling in elongating spermatids of mice.
Q33975168DNA damage-dependent nuclear dynamics of the Mre11 complex
Q28143901DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system
Q46070162Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells.
Q24681223Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer
Q37510041Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair
Q47895242Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis
Q44105234Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo
Q42014431Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.
Q50481186Double-strand break repair in plants is developmentally regulated.
Q26830517Double-strand break repair on sex chromosomes: challenges during male meiotic prophase
Q53061882Dynamics of radiation induced γH2AX foci in chromatin subcompartments of mouse pachytene spermatocytes and round spermatids.
Q48102360Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism
Q41867231Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ).
Q35132485Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair
Q36023638Expression and possible functions of DNA lesion bypass proteins in spermatogenesis
Q28365488Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
Q91991483GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability
Q36072583Generation of stable mutants and targeted gene deletion strains in Cryptococcus neoformans through electroporation
Q34001661Genetic analysis of homologous DNA recombination in vertebrate somatic cells
Q53665792Heterogeneous expression of Ku70 in human tissues is associated with morphological and functional alterations of the nucleus.
Q35571865Heteromorphic sex chromosomes: navigating meiosis without a homologous partner
Q35604547Homologous recombination and gene targeting in plant cells
Q34979828Homologous recombination: ends as the means.
Q28646561Homologous recombinational repair of DNA ensures mammalian chromosome stability
Q39600750Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion
Q73794909Human DNA repair genes
Q33203137Identification of interaction partners and substrates of the cyclin A1-CDK2 complex
Q24294826In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex
Q53487384Increased frequency of asynapsis and associated meiotic silencing of heterologous chromatin in the presence of irradiation-induced extra DNA double strand breaks.
Q39686949Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.
Q37664062Initiation of meiotic recombination in mammals
Q37012010Ku70 and non-homologous end joining protect testicular cells from DNA damage
Q42127065Ku80-deleted cells are defective at base excision repair
Q48503758Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage.
Q38868797Low-fidelity alternative DNA repair carcinogenesis theory may interpret many cancer features and anticancer strategies
Q29618789Mechanism and control of meiotic recombination initiation
Q64388742Mei1 is epistatic to Dmc1 during mouse meiosis
Q36198265Meiosis: inducing variation by reduction
Q28573938Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1beta and SMC3
Q38000414Meiotic double strand breaks repair in sexually reproducing eukaryotes: we are not all equal
Q35541520Meiotic functions of RAD18.
Q35015835Meiotic recombination and spatial proximity in the etiology of the recurrent t(11;22)
Q35543795Mending the Break: Two DNA Double-Strand Break Repair Machines in Eukaryotes
Q27313888Mll5 is required for normal spermatogenesis
Q36226840Molecular aspects of meiotic chromosome synapsis and recombination
Q36792626Molecular targets and mechanisms of radiosensitization using DNA damage response pathways
Q28506028Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages
Q27930222NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae
Q46582502OsDMC1 Is Not Required for Homologous Pairing in Rice Meiosis.
Q47423101PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis.
Q33927291Partners and pathwaysrepairing a double-strand break.
Q30881342Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair
Q33829179Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11.
Q39155608Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
Q47765927RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination
Q35094244Rap1-independent telomere attachment and bouquet formation in mammalian meiosis
Q33912842Recombination: a frank view of exchanges and vice versa.
Q36900915Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis.
Q38328608Regulation of homologous integration in yeast by the DNA repair proteins Ku70 and RecQ.
Q44170735Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants
Q37098468Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways
Q37187725Spermiogenesis and DNA repair: a possible etiology of human infertility and genetic disorders
Q33914715Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time
Q91188176Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline
Q34615813Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.
Q33937428Telomere dysfunction triggers developmentally regulated germ cell apoptosis.
Q36761799Telomere regulation and function during meiosis
Q53671345Testicular expression of small ubiquitin-related modifier-1 (SUMO-1) supports multiple roles in spermatogenesis: silencing of sex chromosomes in spermatocytes, spermatid microtubule nucleation, and nuclear reshaping.
Q35621644The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast
Q48117756The Exonuclease Homolog OsRAD1 Promotes Accurate Meiotic Double-Strand Break Repair by Suppressing Nonhomologous End Joining.
Q43919127The Ku70 DNA-repair protein is involved in centromere function in a grasshopper species.
Q55033314The Kudos of non-homologous end-joining.
Q34609697The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions
Q35980970The life and death of DNA-PK.
Q24291484The role of DNA polymerase activity in human non-homologous end joining
Q61812011Transition from a meiotic to a somatic-like DNA damage response during the pachytene stage in mouse meiosis
Q36002411Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair
Q33984271Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae
Q36011232Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells
Q28506423ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over

Search more.