The shaping of modern human immune systems by multiregional admixture with archaic humans

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The shaping of modern human immune systems by multiregional admixture with archaic humans is …
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P819ADS bibcode2011Sci...334...89A
P356DOI10.1126/SCIENCE.1209202
P3181OpenCitations bibliographic resource ID1199804
P932PMC publication ID3677943
P698PubMed publication ID21868630
P5875ResearchGate publication ID51596850

P50authorSteven G. E. MarshQ7615026
Frank PlummerQ20006879
Peter ParhamQ20980481
Mary CarringtonQ29840699
Martin MaiersQ30524391
Paul J NormanQ33082884
Lisbeth A GuethleinQ48359703
Meral BeksacQ57078421
Joshua KimaniQ78623479
Klara DalvaQ96088012
Alasdair McWhinnieQ125258358
P2093author name stringSubhash Kulkarni
Loren Gragert
Farbod Babrzadeh
Richard E Green
Ma Luo
Derek Middleton
Baback Gharizadeh
Raja Rajalingam
Ann-Margaret Little
Laurent Abi-Rached
Sofia Tavoularis
Matthew J Jobin
P2860cites workA Draft Sequence of the Neandertal GenomeQ22065895
Genetic history of an archaic hominin group from Denisova Cave in SiberiaQ22122173
A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypesQ24563871
Allele frequency net: a database and online repository for immune gene frequencies in worldwide populationsQ24612449
Ethiopians and Khoisan share the deepest clades of the human Y-chromosome phylogenyQ24633152
Out of Africa: modern human origins special feature: explaining worldwide patterns of human genetic variation using a coalescent-based serial founder model of migration outward from AfricaQ24646508
The dawn of human matrilineal diversityQ24656149
A haplotype map of the human genomeQ24679827
KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A * 11 while diminishing avidity for HLA-CQ27657994
The peopling of the Pacific from a bacterial perspectiveQ28307498
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.Q29568902
Repeated adaptive introgression at a gene under multiallelic balancing selectionQ30397929
REJECTOR: software for population history inference from genetic data via a rejection algorithmQ33378018
An X-linked haplotype of Neandertal origin is present among all non-African populationsQ34025486
The IMGT/HLA databaseQ34456881
MHC class I molecules and KIRs in human history, health and survivalQ36047157
MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-responseQ36868743
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.Q37161006
The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B allelesQ41472003
HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ populationQ41560713
Unusual HLA-B alleles in two tribes of Brazilian IndiansQ41623569
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in africansQ46103159
Anthropology. A new view of the birth of Homo sapiensQ46245934
Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific.Q47431117
Cw*1505: a novel HLA-C allele isolated from a B*7301 haplotype.Q48086409
HLA-B73: an atypical HLA-B molecule carrying a Bw6-epitope motif variant and a B pocket identical to HLA-B27.Q48086953
Balancing selection is the main force shaping the evolution of innate immunity genesQ57755879
The HLA polymorphsm of two distinctive South-American Indian tribes: The Kaingang and the GuaraniQ58488516
New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I lociQ59028899
Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populationsQ74480792
P433issue6052
P407language of work or nameEnglishQ1860
P304page(s)89-94
P577publication date2011-10-07
P1433published inScienceQ192864
P1476titleThe shaping of modern human immune systems by multiregional admixture with archaic humans
P478volume334

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cites work (P2860)
Q59052995A Brief Overview of the Last 10 Years of Major Late Pleistocene Discoveries in the Old World: Homo floresiensis, Neanderthal, and Denisovan
Q35031374A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia
Q62381354A dispersal of Homo sapiens from southern to eastern Africa immediately preceded the out-of-Africa migration
Q38688783A genomic perspective on HLA evolution
Q109117027A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
Q28728528A haplotype at STAT2 Introgressed from neanderthals and serves as a candidate of positive selection in Papua New Guinea
Q37320419A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.
Q35593367A novel candidate region for genetic adaptation to high altitude in Andean populations
Q39064744A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species
Q34399840A paleogenomic perspective on evolution and gene function: new insights from ancient DNA.
Q46208923A parsimonious neutral model suggests Neanderthal replacement was determined by migration and random species drift.
Q36334487AD-LIBS: inferring ancestry across hybrid genomes using low-coverage sequence data
Q35574773Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response.
Q61803840Adaptive Introgression: An Untapped Evolutionary Mechanism for Crop Adaptation
Q34312048Adaptive evolution: evaluating empirical support for theoretical predictions
Q35589220Adaptive gene introgression after secondary contact
Q38125824Adaptive introgression in animals: examples and comparison to new mutation and standing variation as sources of adaptive variation
Q48131025Adaptive value of novel MHC immune gene variants
Q35254140Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations
Q27687160Almost 20 years of Neanderthal palaeogenetics: adaptation, admixture, diversity, demography and extinction
Q28244310Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
Q36516246Always on My Mind? Recognition of Attractive Faces May Not Depend on Attention
Q51146852Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.
Q28597755Ancient DNA and human history
Q93101152Ancient Hybridization and Adaptive Introgression of an Invadolysin Gene in Schistosome Parasites
Q26996712Ancient genomics
Q46586148Ancient hybridization and genomic stabilization in a swordtail fish.
Q38931465Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
Q33681777Archaic Adaptive Introgression in TBX15/WARS2.
Q38057640Archaic human genomics
Q28084535Archaic inheritance: supporting high-altitude life in Tibet
Q37416253Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease
Q59489570Balancing selection and introgression of newt immune-response genes
Q34671949Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence
Q100307406Balancing selection versus allele and supertype turnover in MHC class II genes in guppies
Q113530490Black Feminist Theory in Prehistory
Q38888152Cancer tolerance, resistance, pathogenicity and virulence: deconstructing the disease state
Q50533781Characterization and clinical enrichment of HLA-C*07:02-restricted Cytomegalovirus-specific CD8+ T cells.
Q37415636Class I HLA haplotypes form two schools that educate NK cells in different ways
Q38568889Co-evolution of MHC class I and variable NK cell receptors in placental mammals
Q38568891Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction
Q51559939Colonizing the world in spite of reduced MHC variation.
Q52687154Craniomandibular form and body size variation of first generation mouse hybrids: A model for hominin hybridization.
Q43165848Current perspectives on the intensity of natural selection of MHC loci.
Q39203922Cutting the Stone: Health Defined in the Era of Value-based Care
Q37153103Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.
Q57805334Deleterious variation shapes the genomic landscape of introgression
Q46502622Denisovans, Melanesians, Europeans, and Neandertals: The Confusion of DNA Assumptions and the Biological Species Concept
Q38460683Detecting balancing selection in genomes: limits and prospects.
Q38716685Detecting hybridization using ancient DNA.
Q34663979Detection of ancestry informative HLA alleles confirms the admixed origins of Japanese population.
Q91658389Differences in MHC-B diversity and KIR epitopes in two populations of wild chimpanzees
Q47185303Discovery of gorilla MHC-C expressing C1 ligand for KIR.
Q91062563Disease transmission and introgression can explain the long-lasting contact zone of modern humans and Neanderthals
Q46175384Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans
Q40995549Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles
Q38552461Distribution of HLA haplotypes across Japanese Archipelago: similarity, difference and admixture
Q89075998Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection
Q28732404Diverse approaches to analysing the history of human and pathogen evolution: how to tell the story of the past 70 000 years
Q41731150Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3.
Q57133422Don't throw out the sympatric speciation with the crater lake water: fine-scale investigation of introgression provides equivocal support for causal role of secondary gene flow in one of the clearest examples of sympatric speciation
Q38656174EPAS1 variants in high altitude Tibetan wolves were selectively introgressed into highland dogs
Q28607692Early modern human dispersal from Africa: genomic evidence for multiple waves of migration
Q31008103Eigenanalysis of SNP data with an identity by descent interpretation
Q37547474Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by archaic introgression?
Q41380995Evidence for Adaptive Introgression of Disease Resistance Genes Among Closely Related Arabidopsis Species
Q26830001Evidence for archaic adaptive introgression in humans
Q57025279Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans
Q22122318Evolution: What makes a modern human
Q56396355Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes
Q28715053Evolutionary medicine: its scope, interest and potential
Q64079960Fine-Scale Characterization of Genomic Structural Variation in the Human Genome Reveals Adaptive and Biomedically Relevant Hotspots
Q28601941First evidence of hybridization between golden jackal (Canis aureus) and domestic dog (Canis familiaris) as revealed by genetic markers
Q30000009Fixing Formalin: A Method to Recover Genomic-Scale DNA Sequence Data from Formalin-Fixed Museum Specimens Using High-Throughput Sequencing
Q38007345Functional primate genomics--leveraging the medical potential
Q34047556Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations
Q42822566Genetic Time Travel
Q41842884Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids
Q31151856Genetic origin of Behçet's disease population in Denizli, Turkey; population genetics data analysis; historical demography and geographical perspectives based on β-globin gene cluster haplotype variation
Q35168836Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
Q28657760Genetic variation and adaptation in Africa: implications for human evolution and disease
Q36473385Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes
Q21144912Genomic data reveal a complex making of humans
Q40446900Geographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomics
Q30846768Gorilla MHC class I gene and sequence variation in a comparative context
Q41457540HLA class I variation in Iranian Lur and Kurd populations: high haplotype and allotype diversity with an abundance of KIR ligands.
Q94076941HLA-A、HLA-DRB1等位基因多态性与中国南方活动性肺结核患者遗传易感性的相关性
Q52684468HLA-B*07, HLA-DRB1*07, HLA-DRB1*12, and HLA-C*03:02 Strongly Associate With BMI: Data From 1.3 Million Healthy Chinese Adults.
Q46309376Harnessing ancient genomes to study the history of human adaptation
Q36159552How microbiology helps define the rhizome of life
Q34197750Human evolution out of Africa: the role of refugia and climate change
Q36228947Human evolution: a tale from ancient genomes.
Q37126619Human phylogeography and diversity
Q21089902Human remains from the Pleistocene-Holocene transition of southwest China suggest a complex evolutionary history for East Asians
Q92925171Hybridization in human evolution: Insights from other organisms
Q90575788Inferred divergent gene regulation in archaic hominins reveals potential phenotypic differences
Q40387467Innate immunity and human diseases: from archaic introgression to natural selection
Q57049678Intragenus (Homo) variation in a chemokine receptor gene (CCR5)
Q33778843Introgression from domestic goat generated variation at the major histocompatibility complex of Alpine ibex
Q28602436Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors
Q92001070KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors
Q34345310KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand.
Q38849746KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans
Q38870254Living in an adaptive world: Genomic dissection of the genus Homo and its immune response
Q35751442Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population
Q34359146Major histocompatibility complex genomics and human disease
Q34342600Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias
Q55317822Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Mus musculus).
Q56864608Modern human genomes reveal our inner Neanderthal
Q67223691Morphology of the Denisovan phalanx closer to modern humans than to Neanderthals
Q91610767Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6
Q34322389Neandertal origin of genetic variation at the cluster of OAS immunity genes
Q40720760Neanderthal genomics suggests a pleistocene time frame for the first epidemiologic transition
Q34391875Neanderthal introgression at chromosome 3p21.31 was under positive natural selection in East Asians
Q97905413Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations
Q47634422Neanderthal origin of the haplotypes carrying the functional variant Val92Met in the MC1R in modern humans
Q35676477Negligible nuclear introgression despite complete mitochondrial capture between two species of chipmunks
Q58085168Niche adaptation and viral transmission of human papillomaviruses from archaic hominins to modern humans
Q43443647No evidence for nuclear introgression despite complete mtDNA replacement in the Carpathian newt (Lissotriton montandoni).
Q21089837North African populations carry the signature of admixture with Neandertals
Q38005891Nothing in medicine makes sense, except in the light of evolution
Q28706270Nuclear genetic diversity in human lice (Pediculus humanus) reveals continental differences and high inbreeding among worldwide populations
Q28680670On the antiquity of language: the reinterpretation of Neandertal linguistic capacities and its consequences
Q37436665Outlier Loci and Selection Signatures of Simple Sequence Repeats (SSRs) in Flax (Linum usitatissimum L.).
Q34038578Paleontology. Did the Denisovans cross Wallace's Line?
Q24603841Polar and brown bear genomes reveal ancient admixture and demographic footprints of past climate change
Q38798040Population genomics reveals speciation and introgression between Brown Norway rats and their sibling species.
Q51410352Rebooting Human Immunology.
Q49222029Recent advances in understanding evolution of the placenta: insights from transcriptomics.
Q35849756Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes
Q47377500Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression
Q34400818Resurrecting surviving Neandertal lineages from modern human genomes
Q36916982Review: Immunogenetics of human placentation
Q28728225Rhizome of life, catastrophes, sequence exchanges, gene creations, and giant viruses: how microbial genomics challenges Darwin
Q37547317Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation
Q47980242Selective pressures on MHC class II genes in the guppy (Poecilia reticulata) as inferred by hierarchical analysis of population structure
Q38737497Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Q33639328Skewed Exposure to Environmental Antigens Complements Hygiene Hypothesis in Explaining the Rise of Allergy
Q52720612Strong Amerindian Mitonuclear Discordance in Puerto Rican Genomes Suggests Amerindian Mitochondrial Benefit.
Q36071869Strong reproductive isolation and narrow genomic tracts of differentiation among three woodpecker species in secondary contact.
Q34334824Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations
Q91740280THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL
Q36759843The Columbian Exchange as a source of adaptive introgression in human populations
Q35977651The Genetic Cost of Neanderthal Introgression
Q57307457The Hybrid Origin of “Modern” Humans
Q26744597The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach
Q46479541The PNarec method for detection of ancient recombinations through phylogenetic network analysis
Q40690096The Polynesian gene pool: an early contribution by Amerindians to Easter Island
Q64095575The association analysis between HLA-A*26 and Behçet's disease
Q28304347The complete genome sequence of a Neanderthal from the Altai Mountains
Q114381991The contribution of ancient hominin genomes from Siberia to our understanding of human evolution
Q35130067The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease
Q36179949The evolution of human adiposity and obesity: where did it all go wrong?
Q33812612The genomic landscape of Neanderthal ancestry in present-day humans
Q27024634The human condition-a molecular approach
Q36935092The impact of natural selection on health and disease: uses of the population genetics approach in humans
Q27027962The impact of recent events on human genetic diversity
Q58577159The influence of Neanderthal alleles on cytotoxic response
Q36639417The major histocompatibility complex in Old World camelids and low polymorphism of its class II genes
Q97528107The origin of domestication genes in goats
Q28603615The phenotypic legacy of admixture between modern humans and Neandertals
Q26825108The telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive characters
Q28516244Tracing the peopling of the world through genomics
Q35701135Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations
Q39356598Transmission between Archaic and Modern Human Ancestors during the Evolution of the Oncogenic Human Papillomavirus 16.
Q64228645Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC
Q22065651UNEXPECTEDLY MANY EXTINCT HOMININS
Q28067740Understanding rare and common diseases in the context of human evolution
Q34477708Untangling the hybrid nature of modern pig genomes: a mosaic derived from biogeographically distinct and highly divergent Sus scrofa populations
Q37641722Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
Q28660599Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle

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