Abstract is: Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed.
| protein | Q8054 |
| P646 | Freebase ID | /m/02qxvff |
| P6366 | Microsoft Academic ID | 2776791281 |
| P10283 | OpenAlex ID | C2776791281 |
| P637 | RefSeq protein ID | NP_000705.2 |
| NP_001243459.1 | ||
| NP_001243460.1 | ||
| P352 | UniProt protein ID | P30536 |
| P682 | biological process | human ageing | Q332154 |
| signal transduction | Q828130 | ||
| cell population proliferation | Q189101 | ||
| steroid biosynthetic process | Q14358855 | ||
| C21-steroid hormone biosynthetic process | Q14358861 | ||
| apoptotic process | Q14599311 | ||
| transport | Q1435575 | ||
| contact inhibition | Q3151077 | ||
| steroid metabolic process | Q14327702 | ||
| response to pain | Q14331029 | ||
| response to manganese ion | Q14913468 | ||
| response to vitamin B1 | Q14913469 | ||
| cellular response to zinc ion | Q14913471 | ||
| cellular hypotonic response | Q14913472 | ||
| negative regulation of autophagy of mitochondrion | Q21095640 | ||
| establishment of protein localization to mitochondrion | Q21112299 | ||
| maintenance of protein location in mitochondrion | Q21112300 | ||
| negative regulation of mitochondrion organization | Q21495724 | ||
| negative regulation of ATP metabolic process | Q22244023 | ||
| response to testosterone | Q14633904 | ||
| positive regulation of apoptotic process | Q14818063 | ||
| positive regulation of reactive oxygen species metabolic process | Q14818095 | ||
| regulation of cell population proliferation | Q14818120 | ||
| glial cell migration | Q14819482 | ||
| negative regulation of tumor necrosis factor production | Q14819790 | ||
| adrenal gland development | Q14819869 | ||
| response to progesterone | Q14820879 | ||
| regulation of steroid biosynthetic process | Q14851930 | ||
| response to axon injury | Q14852020 | ||
| ion transport | Q14859673 | ||
| positive regulation of mitochondrial depolarization | Q14862708 | ||
| cellular response to lipopolysaccharide | Q14863111 | ||
| negative regulation of nitric oxide biosynthetic process | Q14864455 | ||
| cholesterol transport | Q14864549 | ||
| chloride transport | Q14864717 | ||
| positive regulation of glial cell proliferation | Q14864869 | ||
| lipid transport | Q14872727 | ||
| anion transport | Q14877696 | ||
| heme biosynthetic process | Q14885223 | ||
| peripheral nervous system axon regeneration | Q14890364 | ||
| positive regulation of calcium ion transport | Q14902524 | ||
| negative regulation of protein ubiquitination | Q14904367 | ||
| regulation of cholesterol transport | Q14904545 | ||
| protein targeting to mitochondrion | Q14906653 | ||
| positive regulation of necrotic cell death | Q14907125 | ||
| negative regulation of glial cell proliferation | Q14907476 | ||
| behavioral response to pain | Q14907684 | ||
| P681 | cell component | mitochondrion | Q39572 |
| endoplasmic reticulum | Q79927 | ||
| extracellular exosome | Q903634 | ||
| integral component of membrane | Q14327652 | ||
| mitochondrial outer membrane | Q14330611 | ||
| membrane | Q14349455 | ||
| mitochondrial membranes | Q14860954 | ||
| P702 | encoded by | TSPO | Q14913474 |
| P703 | found in taxon | Homo sapiens | Q15978631 |
| P680 | molecular function | protein binding | Q167149 |
| benzodiazepine receptor activity | Q14913467 | ||
| cholesterol transfer activity | Q29573259 | ||
| cholesterol binding | Q14859820 | ||
| androgen binding | Q14865321 | ||
| transmembrane transporter binding | Q14901685 | ||
| P361 | part of | Translocator protein | Q24720366 |
| TspO/MBR-related superfamily | Q54461079 | ||
| P129 | physically interacts with | PK-11195 | Q7119490 |
| Q64084751 | Corrigendum: Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods |
| Q24337191 | The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA |
| Q24296269 | Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function |
| Q7119490 | PK-11195 | physically interacts with | P129 |
| Q50265451 | TSPO:BZRAP1 [mitochondrial outer membrane] | has part(s) | P527 |
| Q14913474 | TSPO | encodes | P688 |