Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology

journal article published in 2006

Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/MC.20143
P2880NIOSHTIC-2 ID20029571
P698PubMed publication ID16329150
P5875ResearchGate publication ID7440642

P50authorAinsley WestonQ28037208
Channa KeshavaQ28050523
Miriam C. PoirierQ107022221
P2093author name stringVikram Arora
Clifford Pereira
Brinda Mahadevan
William M. Baird
Patrick L. Iversen
Laura J. Schild
Melissa L. Cate
P2860cites workExpression monitoring by hybridization to high-density oligonucleotide arraysQ27860473
Morpholino antisense oligomers: design, preparation, and propertiesQ28243074
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyQ28283241
Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymesQ28576392
Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.Q33389761
Morpholino antisense oligomers: the case for an RNase H-independent structural typeQ33901587
Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradationQ34064082
Understanding the genotoxicity of tamoxifen?Q34263249
Breast cancer chemoprevention: risk-benefit effects of the antioestrogen tamoxifen.Q35194482
Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cellsQ41590943
Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adductsQ42059552
The genotoxicity of tamoxifen: extent and consequences, Kona, Hawaii, January 23, 2003.Q42163644
DNA damage as assessed by 32P-postlabelling in three rat strains exposed to dietary tamoxifen: the relationship between cell proliferation and liver tumour formationQ42279753
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarraysQ43592455
Cumulative exposure to tamoxifen: DNA adducts and liver cancer in the rat.Q43746671
Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifenQ43750888
Change in the gene expression of hepatic tamoxifen-metabolizing enzymes during the process of tamoxifen-induced hepatocarcinogenesis in female ratsQ43918589
Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in ratsQ43956131
Bioactivation of tamoxifen by recombinant human cytochrome p450 enzymesQ43998853
Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolismQ44028559
Risk of malignant mixed mullerian tumors after tamoxifen therapy for breast cancerQ44717416
Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilizationQ45875326
Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 activity in male rats.Q48274353
Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth hormone.Q48558314
Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen.Q53407664
Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats.Q53472390
A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism.Q53473784
Risk of endometrial cancer after tamoxifen treatment of breast cancerQ57307349
Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trialQ72677675
Identification of tamoxifen-DNA adducts formed by alpha-sulfate tamoxifen and alpha-acetoxytamoxifenQ73108097
Tamoxifen-DNA adducts formed by alpha-acetoxytamoxifen N-oxideQ73187898
Drug target validation and identification of secondary drug target effects using DNA microarraysQ77534975
Antisense morpholino oligonucleotide analog induces missplicing of C-myc mRNAQ77834357
P6195funding schemeextramural researchQ124503498
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
tamoxifenQ412178
exposure assessmentQ4008388
DNA adductsQ4153410
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P304page(s)118-125
P577publication date2006-02-01
P1433published inMolecular CarcinogenesisQ15724597
P859sponsorNIOSH Health Effects Laboratory DivisionQ123344455
NIOSH Respiratory Health DivisionQ123344459
P1476titleReduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology
P478volume45

Reverse relations

cites work (P2860)
Q35086803An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.
Q37511330Is tamoxifen a genotoxic carcinogen in women?
Q47593390Liver Genes Expression Induced by Tamoxifen Loaded Solid Lipid Nanoparticles in Wistar Female Rats
Q54215891Molecular insights into the association of obesity with breast cancer risk: relevance to xenobiotic metabolism and CpG island methylation of tumor suppressor genes.

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