Early alterations of brain cellular energy homeostasis in Huntington disease models

journal article published in 2012

Early alterations of brain cellular energy homeostasis in Huntington disease models is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.309849
P2880NIOSHTIC-2 ID20040302
P932PMC publication ID3256882
P698PubMed publication ID22123819

P50authorAlexandra DurrQ60820298
Brandon DurantQ61827272
James P. O'CallaghanQ64408371
Emmanuel BrouilletQ42839922
P2093author name stringHua Yu
Fanny Mochel
Raphael Schiffmann
Sandrine Humbert
Vanessa C. Wheeler
Xingli Meng
P2860cites workDetection of early behavioral markers of Huntington's disease in R6/2 mice employing an automated social home cageQ45293617
Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.Q45295463
High-dose creatine therapy for Huntington disease: a 2-year clinical and MRS study.Q45296832
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouseQ45297101
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtinQ45297269
HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolismQ45298206
Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease.Q45299986
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.Q45300532
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Q45302702
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegenerationQ45302924
Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brainQ46053255
Brain regional levels of adenosine and adenosine nucleotides in rats killed by high-energy focused microwave irradiation.Q49141284
EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAINQ51279822
Quantitative studies of enzyme-substrate compartmentation, functional coupling and metabolic channelling in muscle cells.Q52235772
Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficienciesQ73205350
Huntingtin interacting proteins are genetic modifiers of neurodegenerationQ21145230
Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteinsQ23914346
AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparationQ23918058
Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.Q24811264
Measurement of protein using bicinchoninic acidQ26778491
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Impaired brain creatine kinase activity in Huntington's disease.Q30468147
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseasesQ30478955
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington diseaseQ30499300
Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progressionQ33291754
Increased metabolism in the R6/2 mouse model of Huntington's disease.Q33301810
Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genesQ33609937
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseasesQ33837238
Reduced creatine kinase as a central and peripheral biomarker in Huntington's diseaseQ33945688
Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liverQ34012758
A polymorphic DNA marker genetically linked to Huntington's diseaseQ34255139
Selective defect of in vivo glycolysis in early Huntington's disease striatumQ35634060
3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.Q36318579
Energy deficit in Huntington disease: why it mattersQ37834195
Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopyQ40204332
Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic miceQ40436889
Neurochemistry and toxin models in Huntington's disease.Q40599311
Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's diseaseQ42469950
Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.Q43572865
An increase in the myocardial PCr/ATP ratio in GLUT4 null miceQ43937069
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in miceQ44316963
Creatine supplementation in Huntington's disease: a placebo-controlled pilot trialQ44616594
Measurement of sarcoplasmic reticulum Ca2+ ATPase activity using high-performance liquid chromatographyQ44933316
Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: a quantitative in vivo 1H and 31P magnetic resonance studyQ45039952
Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic miceQ45290567
Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's diseaseQ45290871
Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.Q45292233
P6195funding schemeextramural researchQ124503498
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
Huntington's diseaseQ190564
human behaviorQ3769299
muscular systemQ7060553
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P304page(s)1361-1370
P577publication date2012-01-06
P1433published inJournal of Biological ChemistryQ867727
P859sponsorNIOSH Health Effects Laboratory DivisionQ123344455
P1476titleEarly alterations of brain cellular energy homeostasis in Huntington disease models
P478volume287

Reverse relations

cites work (P2860)
Q28391627A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice
Q28393673A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice
Q28389607A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease
Q45290293A study of molecular changes relating to energy metabolism and cellular stress in people with Huntington's disease: looking for biomarkers
Q38019034AMP-activated protein kinase: new regulation, new roles?
Q38998405AMPK in Neurodegenerative Diseases
Q45288459Abnormal response to cortical activation in early stages of Huntington disease
Q48259811Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons
Q92268464Cerebral bioenergetic differences measured by phosphorus-31 magnetic resonance spectroscopy between bipolar disorder and healthy subjects living in two different regions suggesting possible effects of altitude
Q41930021Co-administration of creatine plus pyruvate prevents the effects of phenylalanine administration to female rats during pregnancy and lactation on enzymes activity of energy metabolism in cerebral cortex and hippocampus of the offspring
Q28394163Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection
Q28393234Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study
Q28396387Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression
Q55295842Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease.
Q43848665Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.
Q58700269Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
Q48231391Effect of leucine administration to female rats during pregnancy and lactation on oxidative stress and enzymes activities of phosphoryltransfer network in cerebral cortex and hippocampus of the offspring
Q38013005Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Q28389950Energy failure: does it contribute to neurodegeneration?
Q28389710Enhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila model
Q48044131Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy
Q28391911Gender differences in the effect of tobacco use on brain phosphocreatine levels in methamphetamine-dependent subjects
Q38243002Genetic modifiers of Huntington's disease
Q28386493HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation
Q28390800Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease
Q98471370Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
Q38663090Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.
Q29248581Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease
Q38918493Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases
Q28391815In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7
Q28394803Inhibition of mitochondrial protein import by mutant huntingtin
Q39014909Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.
Q28394301Metabolism in HD: still a relevant mechanism?
Q64074984Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors
Q28387647Mitochondrial dysfunction in neurodegenerative diseases
Q27004209Modeling Huntington's disease with induced pluripotent stem cells
Q26853025Mouse models of polyglutamine diseases: review and data table. Part I
Q28387085N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease
Q47694590Neuroprotective Effect of Creatine and Pyruvate on Enzyme Activities of Phosphoryl Transfer Network and Oxidative Stress Alterations Caused by Leucine Administration in Wistar Rats
Q45294879Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine
Q28397230Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress
Q27001671PGC-1α, mitochondrial dysfunction, and Huntington's disease
Q27011417Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease
Q28393157Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain
Q28388014Regulation of neuronal bioenergy homeostasis by glutamate
Q28386202Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis
Q28384036Shaping the role of mitochondria in the pathogenesis of Huntington's disease
Q48248957The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Q47442924Towards an Understanding of Energy Impairment in Huntington's Disease Brain
Q39422277Triheptanoin for the treatment of brain energy deficit: A 14-year experience
Q28388261Triheptanoin improves brain energy metabolism in patients with Huntington disease

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