Discovery of novel alpha7 nicotinic receptor antagonists

journal article published in 2010

Discovery of novel alpha7 nicotinic receptor antagonists is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BMCL.2010.06.103
P2880NIOSHTIC-2 ID20037273
P932PMC publication ID3000800
P698PubMed publication ID20638843
P5875ResearchGate publication ID45271276

P50authorJames P. O'CallaghanQ64408371
P2093author name stringGretchen L Snyder
Qiang Zhang
Wei Yao
William J Welsh
Roger L Papke
Hongwen Zhu
Lawrence P Wennogle
Youyi Peng
John Tomesch
P2860cites workProof-of-concept trial of an alpha7 nicotinic agonist in schizophreniaQ24338876
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptorQ24647112
Neuronal nicotinic receptors in the human brainQ28141480
Looking back on the discovery of alpha-bungarotoxinQ28146141
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatmentQ28324465
Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cellsQ28379148
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ28842973
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structuresQ29619985
Property distribution of drug-related chemical databases.Q30855791
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptorsQ31147815
Conformational sampling of druglike molecules with MOE and catalyst: implications for pharmacophore modeling and virtual screeningQ33365646
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.Q33650110
3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive mannerQ34446347
Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptorsQ34484845
Neuronal nicotinic receptors: a perspective on two decades of drug discovery researchQ34657532
Nicotinic acetylcholine receptors as targets for antidepressants.Q34761238
Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligandsQ35137379
Nicotine and nicotinic receptor involvement in neuropsychiatric disordersQ35644549
Nicotinic receptors and schizophreniaQ35841683
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirationsQ36201558
Strategies for compound selectionQ36393838
Selective alpha7 nicotinic acetylcholine receptor ligandsQ36512768
Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonistsQ37314383
alpha7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma?Q37555312
Structure and function of neuronal nicotinic acetylcholine receptorsQ41330529
PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptorQ44158787
Characterization of curaremimetic neurotoxin binding sites on membrane fractions derived from the human medulloblastoma clonal line, TE671.Q45226870
Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptorsQ48203305
The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodentsQ48269550
Modification of seizure activity by electrical stimulation. I. After-discharge threshold.Q48793610
[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic studyQ71513186
Nicotinic antagonists in the treatment of nerve agent intoxicationQ81455159
P6195funding schemeextramural researchQ124503498
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectmanufacturingQ187939
neurological disorderQ3339235
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P304page(s)4825-30
P577publication date2010-08-15
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P859sponsorNIOSH Health Effects Laboratory DivisionQ123344455
P1476titleDiscovery of novel alpha7 nicotinic receptor antagonists
P478volume20

Reverse relations

cites work (P2860)
Q35733853Design and Synthesis of Nicotinic Acetylcholine Receptor Antagonists and their Effect on Cognitive Impairment.
Q58778215Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
Q90454303Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors
Q38126962Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors
Q28388268Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists

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