Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis

scientific article (published 2015-07-30)

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis is …
instance of (P31):
meta-analysisQ815382
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/14651858.CD009730.PUB2
P932PMC publication ID6481905
P698PubMed publication ID26226131
P5875ResearchGate publication ID280600884

P50authorMatthew N HurleyQ57565689
Andrew P PrayleQ58881618
P2093author name stringPatrick Flume
P2860cites workSingle versus combination intravenous antibiotic therapy for people with cystic fibrosisQ24194967
Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosisQ24200604
Duration of intravenous antibiotic therapy in people with cystic fibrosisQ24202855
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosisQ24240388
Comparative study of the antibacterial activity of amikacin and tobramycin during Pseudomonas pulmonary infection in patients with cystic fibrosisQ71629320
Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosisQ71786937
[Economic aspects in treatment of cystic fibrosis with chronic pulmonary pseudomonas infection. Ambulatory intravenous therapy in comparison with inpatient treatment]Q74103246
Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidimeQ74523219
[Ambulatory vs. inpatient intravenous antibiotic therapy in mucoviscidosis patients--a controlled study]Q74634519
Comparison of a beta-lactam alone versus beta-lactam and an aminoglycoside for pulmonary exacerbation in cystic fibrosisQ77222399
[Comparison of the pharmacokinetics of tobramycin administered in a single daily dose or in 3 doses in cystic fibrosis]Q77402037
Once-daily tobramycin in cystic fibrosis: better for clinical outcome than thrice-daily tobramycin but more resistance development?Q80050474
Efficacy and safety of intravenous meropenem and tobramycin versus ceftazidime and tobramycin in cystic fibrosisQ80980323
Twice vs three-times daily antibiotics in the treatment of pulmonary exacerbations of cystic fibrosisQ85155745
Ceftazidime in patients with pseudomonas infectionsQ54495367
Randomized, double-blind evaluation of azlocillin for the treatment of pulmonary exacerbations of cystic fibrosisQ54498316
Clinical and Bacteriological Responses to Three Antibiotic Regimens for Acute Exacerbations of Cystic Fibrosis: Tlcarcillln-Tobramycin, Azlocillin-Tobramycin, and Azlocillin-PlaceboQ54501407
Population pharmacokinetics of tobramycin administered thrice daily and once daily in children and adults with cystic fibrosisQ61912446
Acute pulmonary exacerbations in cystic fibrosis. A double-blind trial of tobramycin and placebo therapyQ67252347
Reduction of sputum Pseudomonas aeruginosa density by antibiotics improves lung function in cystic fibrosis more than do bronchodilators and chest physiotherapy aloneQ67285211
Comparison of 6 and 8 hourly tobramycin dosing intervals in treatment of pulmonary exacerbations in cystic fibrosis patientsQ67992228
Aerosol scintigraphy in the assessment of therapy for cystic fibrosisQ68095176
[Intravenous administration of antibiotics at home in patients with cystic fibrosis improves quality of life]Q68134669
Prospective controlled study of home and hospital therapy of cystic fibrosis pulmonary diseaseQ68163093
Randomized trial of ceftazidime versus placebo in the management of acute respiratory exacerbations in patients with cystic fibrosisQ68205329
Tolerance and safety of ciprofloxacin in paediatric patientsQ68687338
Ciprofloxacin monotherapy for acute pulmonary exacerbations of cystic fibrosisQ68955379
Therapeutic evaluation of piperacillin for acute pulmonary exacerbations in cystic fibrosisQ69035811
Treatment of Pseudomonas lung infection in cystic fibrosis with piperacillin plus tobramycin versus ceftazidime monotherapy: preliminary communicationQ69238726
Antipseudomonal therapy in cystic fibrosis: aztreonam and amikacin versus ceftazidime and amikacin administered intravenously followed by oral ciprofloxacinQ69255054
Comparison of efficacy and tolerance of intravenously and orally administered ciprofloxacin in cystic fibrosis patients with acute exacerbations of lung infectionQ69671407
Ceftazidime compared with gentamicin and carbenicillin in patients with cystic fibrosis, pulmonary pseudomonas infection, and an exacerbation of respiratory symptoms. British Thoracic Society Research CommitteeQ69867654
Intensive treatment of pseudomonas chest infection in cystic fibrosis: a comparison of tobramycin and ticarcillin, and netilmicin and ticarcillinQ69888145
The role of piperacillin therapy in pulmonary exacerbations of cystic fibrosis: a controlled studyQ69919517
Ticarcillin/clavulanic acid pharmacokinetics in children and young adults with cystic fibrosisQ70113968
A double-blind controlled trial of anti-Pseudomonas chemotherapy of acute respiratory exacerbations in patients with cystic fibrosisQ70161420
Comparative efficacy and tolerance study of azlocillin and carbenicillin in patients with cystic fibrosis: a double blind studyQ70282593
Ceftazidime in cystic fibrosis: pharmacokinetics and therapeutic responseQ70282699
Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosisQ70282708
Experience with ceftazidime in cystic fibrosisQ70282714
Efficacy of inhaled tobramycin in the treatment of pulmonary exacerbations in children with cystic fibrosisQ70438995
Treatment of lower respiratory tract infections due to Pseudomonas aeruginosa in patients with cystic fibrosisQ70521059
[Aminoglycosides in patients with mucoviscidosis and pulmonary exacerbation. Comparison of once or three times daily administration]Q70591780
Pharmacokinetics of once-daily versus thrice daily tobramycin in cystic fibrosis patientsQ71338545
Measuring inconsistency in meta-analysesQ27860655
The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus PanelQ28270334
Dosage adjustment and clinical outcomes of long-term use of high-dose tobramycin in adult cystic fibrosis patientsQ28325196
Sensitization to aztreonam and cross-reactivity with other beta-lactam antibiotics in high-risk patients with cystic fibrosisQ28334722
Cefsulodin sodium therapy in cystic fibrosis patientsQ30451333
Classifying severity of cystic fibrosis lung disease using longitudinal pulmonary function dataQ31049430
Phylogenetic and metabolic diversity of bacteria associated with cystic fibrosis.Q33633034
Determination of the minimal clinically important difference scores for the Cystic Fibrosis Questionnaire-Revised respiratory symptom scale in two populations of patients with cystic fibrosis and chronic Pseudomonas aeruginosa airway infectionQ33650377
Oral, inhaled, and intravenous antibiotic choice for treating pulmonary exacerbations in cystic fibrosis.Q33725822
Pharmacokinetics of ciprofloxacin in cystic fibrosisQ33741046
Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbationQ33744911
Minimisation of aminoglycoside toxicity in patients with cystic fibrosisQ33775991
Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus.Q34098657
Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study GroupQ34290556
Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilienceQ34307354
Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age.Q34324105
Pharmacokinetics of intravenous and oral linezolid in adults with cystic fibrosisQ35065732
Nutritional impact of antipseudomonas intravenous antibiotic courses in cystic fibrosisQ35255315
Efficacy, tolerance, and pharmacokinetics of once daily tobramycin for pseudomonas exacerbations in cystic fibrosisQ35259780
Long-term follow up of changes in FEV1 and treatment intensity during Pseudomonas aeruginosa colonisation in patients with cystic fibrosisQ35532709
Randomized double-blind evaluation of ceftazidime dose ranging in hospitalized patients with cystic fibrosis.Q35539743
Intravenous colistin sulphomethate in acute respiratory exacerbations in adult patients with cystic fibrosisQ35563227
The value of serum IgG titres against Pseudomonas aeruginosa in the management of early pseudomonal infection in cystic fibrosisQ35627870
Azlocillin compared with carbenicillin in the treatment of bronchopulmonary infection due to Pseudomonas aeruginosa in cystic fibrosisQ36136038
Survey of acute renal failure in patients with cystic fibrosis in the UK.Q36225726
Ciprofloxacin: comparative data in cystic fibrosisQ36464503
Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesisQ36771148
A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patientsQ37185481
Continuous versus intermittent infusions of ceftazidime for treating exacerbation of cystic fibrosisQ37333080
Quantitative analysis of the human airway microbial ecology reveals a pervasive signature for cystic fibrosisQ37502050
Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbationsQ37591703
Pulmonary exacerbation: towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trialsQ37887195
Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trialQ38488018
Sequential ciprofloxacin therapy in pediatric cystic fibrosis: comparative study vs. ceftazidime/tobramycin in the treatment of acute pulmonary exacerbations. The Cystic Fibrosis Study GroupQ38505793
Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosisQ38921233
Management of acute pulmonary exacerbations in cystic fibrosis: a critical appraisalQ39820716
Increased oral bioavailability of ciprofloxacin in cystic fibrosis patientsQ40284573
A comparative study of ticarcillin plus tobramycin versus carbenicillin plus gentamicin for the treatment of serious infections due to gram-negative bacilliQ40380967
Safety of bronchoalveolar lavage in young children with cystic fibrosisQ40410131
Controlled trial of aztreonam vs. tobramycin and azlocillin for acute pulmonary exacerbations of cystic fibrosis.Q40788262
Comparison of piperacillin alone versus piperacillin plus tobramycin for treatment of respiratory infections in children with cystic fibrosisQ40789277
Ceftazidime alone and in combination in patients with cystic fibrosis: lack of efficacy in treatment of severe respiratory infections caused by Pseudomonas cepaciaQ40835202
Alternative antibiotics for the treatment of Pseudomonas infections in cystic fibrosisQ40835273
Azlocillin with and without an aminoglycoside against respiratory tract infections in children with cystic fibrosis.Q40856873
Treatment of pulmonary infections in patients with cystic fibrosis: A comparative study of ticarcillin and gentamicinQ41221196
Absence of cochleotoxicity measured by standard and high-frequency pure tone audiometry in a trial of once- versus three-times-daily tobramycin in cystic fibrosis patientsQ41474199
An in vivo assessment of the tobramycin/ticarcillin interaction in cystic fibrosis patientsQ42058123
Elective versus symptomatic antibiotic treatment in cystic fibrosis patients with chronic Pseudomonas infection of the lungsQ42200170
Continuous vs thrice-daily ceftazidime for elective intravenous antipseudomonal therapy in cystic fibrosisQ43276197
Tobramycin once- vs thrice-daily for elective intravenous antipseudomonal therapy in pediatric cystic fibrosis patientsQ43276198
Continuous infusion of ceftazidime in cystic fibrosisQ43522441
Immediate and prolonged clinical efficacy of ceftazidime versus ceftazidime plus tobramycin in chronic Pseudomonas aeruginosa infection in cystic fibrosisQ43525951
Ciprofloxacin versus tobramycin plus azlocillin in pulmonary exacerbations in adult patients with cystic fibrosisQ43574441
Efficacy of once-daily tobramycin monotherapy for acute pulmonary exacerbations of cystic fibrosis: a preliminary studyQ43599722
Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?Q43607414
Effect of inhaled tobramycin on early Pseudomonas aeruginosa colonisation in patients with cystic fibrosisQ43754593
Once-daily tobramycin in the treatment of adult patients with cystic fibrosisQ43897091
Comparative yearly growth rate of children with mucoviscidosis treated and not treated with ciprofloxacin:clinicomorphological comparisonsQ43907321
Use of ciprofloxacin in cystic fibrosis patientsQ43922470
Efficacy of inhaled amikacin as adjunct to intravenous combination therapy (ceftazidime and amikacin) in cystic fibrosisQ43989705
Comparative pharmacokinetics of ciprofloxacin and ofloxacin in cystic fibrosis patientsQ44067245
Distribution and elimination of tobramycin administered in single or multiple daily doses in adult patients with cystic fibrosisQ44161000
Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosisQ44248035
Comparison of piperacillin vs. ticarcillin plus tobramycin in the treatment of acute pulmonary exacerbations of cystic fibrosisQ44324948
Controlled trial of ceftazidime vs. ticarcillin and tobramycin in the treatment of acute respiratory exacerbations in patients with cystic fibrosisQ44359710
Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis?Q44379999
Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosisQ44603672
A comparison of aztreonam and ceftazidime in the treatment of respiratory infections in adults with cystic fibrosisQ44732587
Piperacillin and tobramycin in the treatment of Pseudomonas lung infections in cystic fibrosisQ45031290
Anti-pseudomonas activity of azlocillin during pulmonary infection in patients with cystic fibrosisQ45220191
Single daily tobramycin dosing in cystic fibrosis: is it better for the patients or the bugs?Q45262876
Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis--the TOPIC study: a randomised controlled trialQ45262881
Oral ciprofloxacin vs. intravenous ceftazidime plus tobramycin in pediatric cystic fibrosis patients: comparison of antipseudomonas efficacy and assessment of safety with ultrasonography and magnetic resonance imaging. Cystic Fibrosis Study GroupQ46658825
The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin in the treatment of acute pulmonary exacerbations in patients with cystic fibrosisQ46763845
Relationship between rates of antimicrobial consumption and the incidence of antimicrobial resistance in Staphylococcus aureus and Pseudomonas aeruginosa isolates from 47 French hospitalsQ46906475
Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycinQ46984010
Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosisQ47746290
Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trialQ47751601
Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis.Q51449327
Home intravenous therapy in cystic fibrosis: a prospective randomized trial examining clinical, quality of life and cost aspects.Q52525472
Pharmaceutical intervention in the care of cystic fibrosis patients.Q52541814
Impact of recent pulmonary exacerbations on quality of life in patients with cystic fibrosis.Q53456951
Efficacy of oral fluoroquinolones versus conventional intravenous antipseudomonal chemotherapy in treatment of cystic fibrosis.Q54131581
Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. infections in cystic fibrosis patients.Q54168335
The efficacy and safety of ciprofloxacin and ofloxacin in chronic Pseudomonas aeruginosa infection in cystic fibrosis.Q54399290
Ceftazidime monotherapy vs. combined therapy in Pseudomonas pulmonary infections in cystic fibrosis.Q54404421
Antimicrobial therapy of Pseudomonas pulmonary exacerbations in cystic fibrosis. A prospective evaluation of netilmicin plus azlocillin versus netilmicin plus ticarcillin.Q54437947
Comparison of cefoperazone sodium vs methicillin, ticarcillin, and tobramycin in treatment of pulmonary exacerbations in patients with cystic fibrosis.Q54452683
P433issue7
P921main subjectantibioticQ12187
cystic fibrosisQ178194
P304page(s)CD009730
P577publication date2015-07-30
P1433published inCochrane Database of Systematic ReviewsQ15750361
P1476titleIntravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis