Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells

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Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2007.07.033
P698PubMed publication ID17825285

P2093author name stringQing Yang
Yuichi Sugiyama
Chikako Nakai
Reiko Onuki
P2860cites workRegulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathwayQ24671083
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2Q24676628
Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin familyQ24678695
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranesQ28204937
Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockoutQ28508442
Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestineQ28510081
Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytesQ28564528
Ezrin-radixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epitheliaQ28576075
Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liverQ28581783
Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletonsQ28582916
The ezrin protein family: membrane-cytoskeleton interactions and disease associationsQ30428648
Regulation of cortical structure by the ezrin-radixin-moesin protein familyQ33536481
ERM proteins in cell adhesion and membrane dynamicsQ33632981
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistanceQ33784453
ERM-Merlin and EBP50 protein families in plasma membrane organization and functionQ34059680
Distinct cell type-specific expression of scaffolding proteins EBP50 and E3KARP: EBP50 is generally expressed with ezrin in specific epithelia, whereas E3KARP is not.Q34118310
Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranesQ34446936
Trafficking of canalicular ABC transporters in hepatocytesQ34516253
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletonsQ36382880
Three determinants in ezrin are responsible for cell extension activityQ37387020
P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid originQ38293153
Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell lineQ40353732
Cellular distributions of the ERM proteins in MDCK epithelial cells: regulation by growth and cytoskeletal integrityQ40806310
ICAM-2 redistributed by ezrin as a target for killer cellsQ41183913
Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cellsQ41816909
Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: role of the cytoskeletonQ42496447
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein familyQ42720142
New and better protocols for a short-term Caco-2 cell culture systemQ43938185
Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes.Q45232119
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.Q52552319
Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis.Q54103963
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.Q54560172
Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3Q79493293
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectRadixinQ3928887
Caco-2Q5016050
ATP binding cassette subfamily C member 2Q21118794
ezrinQ22679669
P304page(s)3517-25
P577publication date2007-10-01
P1433published inExperimental Cell ResearchQ1524289
P1476titleEzrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells
P478volume313

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cites work (P2860)
Q33881922Bile formation and secretion
Q36390520Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis
Q35795744Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 Proteins
Q54405469Ezrin regulates the expression of Mrp2/Abcc2 and Mdr1/Abcb1 along the rat small intestinal tract.
Q51730922Forecast of actin-binding proteins as the oncotarget in osteosarcoma - a review of mechanism, diagnosis and therapy.
Q45932397Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine.
Q47110047Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer
Q39155176Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells
Q38759057SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells
Q35555968The ERM protein, ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection
Q59042557The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter

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