The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation

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The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKM661
P932PMC publication ID2094069
P698PubMed publication ID17827210
P5875ResearchGate publication ID6013719

P2093author name stringWei Chen
Robert G Roeder
P2860cites workA novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulationQ22008779
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activatorsQ22009365
Composite co-activator ARC mediates chromatin-directed transcriptional activationQ22009528
The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCsQ22254389
The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitroQ24292376
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylationQ24297166
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesisQ24298511
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcriptionQ24306465
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashionQ24312064
Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complexQ24313231
Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteinsQ24529839
The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexesQ24554276
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free systemQ24601592
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptorsQ24646387
Structure and specificity of nuclear receptor-coactivator interactionsQ27765991
The nuclear receptor superfamily: the second decadeQ27860725
The coregulator exchange in transcriptional functions of nuclear receptorsQ28131759
Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptorQ28250779
Dynamic regulation of pol II transcription by the mammalian Mediator complexQ28251057
Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liverQ28585245
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone actionQ28589180
Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptorsQ28594313
Molecular mechanisms of action of steroid/thyroid receptor superfamily membersQ29547540
Nuclear receptor coregulators: cellular and molecular biologyQ29547588
New insights into glucocorticoid and mineralocorticoid signaling: lessons from gene targetingQ33784698
A ligand binding domain mutation in the mouse glucocorticoid receptor functionally links chromatin remodeling and transcription initiationQ33960610
Specific structural motifs determine TRAP220 interactions with nuclear hormone receptorsQ33964709
Progesterone and Glucocorticoid Receptors Recruit Distinct Coactivator Complexes and Promote Distinct Patterns of Local Chromatin ModificationQ35001845
Mechanisms of glucocorticoid signallingQ35920395
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifsQ38332548
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteinsQ38335656
Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinaseQ38362403
Steroid receptor regulated transcription of specific genes and gene networksQ39838638
MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptorQ40359705
Role of mediator in transcriptional activation by the aryl hydrocarbon receptorQ40598216
Differential activity of progesterone and glucocorticoid receptors on mouse mammary tumor virus templates differing in chromatin structureQ41108970
Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cellsQ45032637
Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA.Q47318453
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectglucocorticoidQ422549
LBD domain bindingQ21106427
Mediator complex subunit 1Q21173409
Mediator complex subunit 1Q21985771
P304page(s)6161-9
P577publication date2007-01-01
P1433published inNucleic Acids ResearchQ135122
P1476titleThe Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
P478volume35

Reverse relations

cites work (P2860)
Q24336306CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes
Q30491504Complexity in transcription control at the activation domain-mediator interface
Q37374607Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis
Q35600094Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module
Q37899566Dynamic allostery: linkers are not merely flexible
Q60907382E47 modulates hepatic glucocorticoid action
Q64103107Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages
Q37932011Gene-specific transcription activation via long-range allosteric shape-shifting
Q37926957Genetic variants in candidate genes influencing NAFLD progression
Q39749237Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions
Q34495315HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter
Q33826208MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis
Q38713135Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization
Q26995848Mediator-dependent nuclear receptor function
Q38207093Minireview: new molecular mediators of glucocorticoid receptor activity in metabolic tissues
Q90412314Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma
Q36164321Regulation of triglyceride metabolism by glucocorticoid receptor
Q28299679The Mediator complex and transcription regulation
Q28507597The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development
Q36775635Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes.

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