Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

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Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1039608705
P356DOI10.1038/359644A0
P3181OpenCitations bibliographic resource ID3662916
P698PubMed publication ID1406996
P5875ResearchGate publication ID21748711

P2093author name stringS M Keyse
E A Emslie
P2860cites workCloning of a cDNA for a major human protein-tyrosine-phosphataseQ24558722
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1Q24564855
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase familyQ24611364
Improved tools for biological sequence comparisonQ24652199
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradationQ27860824
Oncogenes and signal transductionQ29547804
Protein-tyrosine kinasesQ29616546
Role of free radicals and catalytic metal ions in human disease: an overviewQ29618022
Ionizing radiation regulates expression of the c-jun protooncogeneQ33709934
Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coliQ33741037
Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arseniteQ33828009
The cdc25 M-phase inducer: an unconventional protein phosphataseQ35225348
Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissuesQ35442498
Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymesQ36408150
Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cellsQ36472638
Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblastsQ36725860
Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cellsQ36766954
Chemical changes induced in DNA by ionizing radiation.Q39499333
Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimuriumQ41771946
A Tyr/Ser protein phosphatase encoded by vaccinia virusQ42621801
Mutagenicity of hydrogen peroxide in V79 Chinese hamster cellsQ69406256
P433issue6396
P407language of work or nameEnglishQ1860
P921main subjectoxidative stressQ898814
peptidyl-tyrosine dephosphorylationQ14878357
dual specificity phosphatase 1Q21171041
P304page(s)644-7
P577publication date1992-10-15
P1433published inNatureQ180445
P1476titleOxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase
P478volume359

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cites work (P2860)
Q33947411A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs
Q30414621A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts
Q34734589A negative regulator of MAP kinase causes depressive behavior
Q28592281A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury
Q28581888A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation
Q28572431A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate
Q28215085A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway
Q30723911A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines
Q41070272A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase.
Q40755233A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin
Q36273802A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells
Q77385045A subset of newly synthesized polypeptides in mitochondria from human endothelial cells exposed to hydroperoxide stress
Q33825016AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma
Q40750221ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage
Q36560144Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe
Q28589421Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes
Q71825016Activation of phosphotyrosine phosphatase activity is associated with decreased differentiation in adult bovine lens
Q36560187Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene
Q37525966Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravity
Q28579062Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells
Q36235038Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
Q36395686An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia.
Q40776171An early growth response protein (Egr) 1 cis-element is required for gonadotropin-releasing hormone-induced mitogen-activated protein kinase phosphatase 2 gene expression
Q40493476An emerging family of dual specificity MAP kinase phosphatases
Q36569112An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations
Q37627292An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein
Q39630957Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction
Q41431597Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun
Q40474575Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.).
Q73458916Antioxidant adaptive response in human blood mononuclear cells exposed to UVB
Q41191889Antioxidants, redox-regulated transcription factors, and inflammation
Q40953209Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal-transduction pathways
Q42631549Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase
Q34134934CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential
Q73155209CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin
Q24532201Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation
Q59792223Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling
Q24296482Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
Q41515353Chemotherapy-induced apoptosis
Q36757154Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro
Q40106887Combination of ZD55-MnSOD therapy with 5-FU enhances antitumor efficacy in colorectal cancer
Q53792133Comparison of different isolation techniques prior gene expression profiling of blood derived cells: impact on physiological responses, on overall expression and the role of different cell types.
Q40839080Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in dif
Q35977354Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis
Q59881138Constitutive ERK1/2 Activation in Esophagogastric Rib Bone Marrow Micrometastatic Cells Is MEK-independent
Q24323312Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1
Q34453872Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10.
Q24294827Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
Q28137870Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
Q60595349Cycloheximide-induced cPLA2 activation is via the MKP-1 down-regulation and ERK activation
Q40393322DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.
Q44983498Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes
Q53171569Decreased total MKP-1 protein levels predict poor prognosis in breast cancer.
Q34904455Delivery systems for antioxidant nutrients
Q37634525Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes
Q24537701Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.
Q39820435Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers
Q36877248Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
Q40939318Different sensitivities of p42 mitogen-activated protein kinase to phorbol ester and okadaic acid tumor promoters among cell types
Q28505723Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes
Q24324448Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase
Q33949436Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically
Q41774460Dissection of stress-activated glucose transport from insulin-induced glucose transport in mammalian cells using wortmannin and ML-9
Q28208304Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
Q36521882Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions
Q40600008Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against
Q38332848Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1.
Q41143520Down-regulation of mammalian mitochondrial RNAs during oxidative stress.
Q58542311Dual-specificity MAP kinase phosphatases in health and disease
Q40006411E1a gene expression blocks the ERK1/2 signaling pathway by promoting nuclear localization and MKP up-regulation: implication in v-H-Ras-induced senescence
Q47141162Effect of Morinda citrifolia (Noni)-Enriched Diet on Hepatic Heat Shock Protein and Lipid Metabolism-Related Genes in Heat Stressed Broiler Chickens
Q51601973Effect of acute heat shock on gene expression by human peripheral blood mononuclear cells.
Q44002712Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosis
Q24314352Expression and alternative splicing of the cytochrome P-450 CYP2A7
Q47399907Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation
Q42207572Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis
Q54629206Expression, purification and crystallization of human phosphotyrosine phosphatase 1B.
Q28142838Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway
Q22253383FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain
Q44557848Feedback regulation of MAPK signalling by an RNA-binding protein
Q38635962Fine-tuning MAPK signaling in the brain: The role of MKP-1.
Q36454955Free radical biology and medicine: it's a gas, man!
Q57943745Free radical pathways in the inflammatory response
Q47835394Function of the Mos/MAPK pathway during oocyte maturation in the Japanese brown frog Rana japonica
Q43039948Gene expression patterns in livers of Hispanic patients infected with hepatitis C virus
Q24797857Gene expression profile of AIDS-related Kaposi's sarcoma
Q40775496Gene expression profiling of the response to thermal injury in human cells
Q35658278Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells.
Q28943482Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer
Q34595730Glutathione S-transferases and related proteins from pathogenic human parasites behave as immunomodulatory factors.
Q53664271Haploinsufficiency MYBPC3 mutations: another stress induced cardiomyopathy? Let's take a look!
Q42826109Heat shock of human synovial and dermal fibroblasts induces delayed up-regulation of collagenase-gene expression
Q37337809Heat shock protein 27 is a potential indicator for response to YangZheng XiaoJi and chemotherapy agents in cancer cells.
Q34421860Heat shock proteins in the photobiology of human skin
Q40409141Heat shock-mediated regulation of MKP-1.
Q51701467Heat stress-induced phosphorylation of FoxO3a signalling in rat skeletal muscle.
Q59003698Heat-stress induced modulation of protein phosphorylation in virulent promastigotes of Leishmania donovani
Q54064851High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Q28573873Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms
Q35574222Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction
Q24290139Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death
Q49049676Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes.
Q41281825Hydrogen peroxide-and fetal bovine serum-induced DNA synthesis in vascular smooth muscle cells: positive and negative regulation by protein kinase C isoforms
Q33932921Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis
Q27939714Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide.
Q41609504Identification of a dual-specificity protein phosphatase that inactivates a MAP kinase from Arabidopsis
Q35805022Identification of a neuregulin and protein-tyrosine phosphatase response element in the nicotinic acetylcholine receptor epsilon subunit gene: regulatory role of an Rts transcription factor
Q44215781Identification of cytokine-induced nuclear factor-kappaB target genes in ovarian and breast cancer cells
Q33922600Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays
Q39512993Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display
Q24673364Inactivation of Dual-Specificity Phosphatases Is Involved in the Regulation of Extracellular Signal-Regulated Kinases by Heat Shock and Hsp72
Q41364422Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.
Q24648132Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
Q39813623Induced apoptosis by mild hyperthermia occurs via telomerase inhibition on the three human myeloid leukemia cell lines: TF-1, K562, and HL-60.
Q48076178Induction of CL100 protein tyrosine phosphatase following transient forebrain ischemia in the rat brain
Q72770999Induction of protein-tyrosine phosphatase LC-PTP by IL-2 in human T cells. LC-PTP is an early response gene
Q42120529Inhibition of mitogen-activated protein kinase by a Drosophila dual-specific phosphatase
Q49035659Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade
Q43580409Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation
Q34564825Invited review: Effects of heat and cold stress on mammalian gene expression
Q71798209Involvement of MAP kinase in insulin signalling revealed by non-invasive imaging of luciferase gene expression in single living cells
Q33776998Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells
Q41293121Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.
Q40342706Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide
Q40806884Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
Q24306813Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase
Q36681236Isolation of a novel ras-recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3-E1.
Q48968196Keep the 'phospho' on MAPK, be happy
Q33762645Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis
Q39701404Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics
Q36023711Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts
Q37095279Long-term dynamics of multisite phosphorylation
Q34962087MAP Kinase Phosphatase-1 and Septic Shock.
Q28593793MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha
Q45230902MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise.
Q28574998MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon
Q42829930MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation
Q37186699MAP kinase phosphatase-1, a critical negative regulator of the innate immune response
Q21999790MAP kinase phosphatases
Q41461105MAP kinases in mitogenesis and development
Q36743545MAPK phosphatases--regulating the immune response
Q43580957MKP-1 as a target for pharmacological manipulations in PC12 cell survival
Q38973553MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation
Q37431342MKP-1 is necessary for T cell activation and function.
Q47163224MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance
Q44651797MKP-2: out of the DUSP-bin and back into the limelight.
Q39662004MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells
Q33883578MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases
Q27937653MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae
Q54971810Manganese superoxide dismutase negatively regulates the induction of apoptosis by 5-fluorouracil, peplomycin and gamma-rays in squamous cell carcinoma cells.
Q37875160Mechanisms of resistance to photodynamic therapy
Q42437341Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular-signal-regulated kinase and c-Jun NH2-terminal kinase).
Q34348638Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process
Q44178051Microarray and real-time RT-PCR analyses of differential human gene expression patterns induced by severe acute respiratory syndrome (SARS) coronavirus infection of Vero cells
Q43596814Mitogen activated protein kinase plays a significant role in metaphase II arrest, spindle morphology, and maintenance of maturation promoting factor activity in bovine oocytes
Q34073341Mitogen-activated protein [MAP] kinase pathways in plants: versatile signaling tools
Q36301783Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Q39194237Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype
Q43560111Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells
Q38151234Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target
Q28361523Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis
Q39771527Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation
Q34756182Mitogen-activated protein kinase phosphatase-1 is a key regulator of hypoxia-induced vascular endothelial growth factor expression and vessel density in lung
Q39977638Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation
Q38547301Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade
Q28564325Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes
Q42129337Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons
Q40738241Modular structure of a docking surface on MAPK phosphatases
Q41413301Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and D-alpha-tocopherol in vascular smooth muscle cells
Q46064013Molecular characterization of a tyrosine-specific protein phosphatase encoded by a stress-responsive gene in Arabidopsis
Q28188330Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain
Q22010209Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5
Q22010889Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis
Q30874196Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3.
Q36805693Molecular cloning and expression of a unique rabbit osteoclastic phosphotyrosyl phosphatase.
Q24319662Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4
Q33346818Molecular imaging-assisted optimization of hsp70 expression during laser-induced thermal preconditioning for wound repair enhancement
Q57279989Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies
Q71324499Multiple intracellular MAP kinase signaling cascades
Q73905967Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors
Q24535855Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
Q40255132Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase
Q40599257Nerve growth factor-dependent survival of CESS B cell line is mediated by increased expression and decreased degradation of MAPK phosphatase 1.
Q24295007New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding
Q40644601Novel genes regulated by gonadotropins in granulosa cells: new perspectives on their physiological functions
Q41679282Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants
Q38360337Nuclear phosphatases and the proteasome in suppression of STAT1 activity in hepatocytes
Q72109739Okadaic acid potentiates heat-induced activation of erk2
Q41190428Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway
Q41123019Oscillatory dynamics of p38 activity with transcriptional and translational time delays
Q77220692Osmotic regulation of the heat shock response in primary rat hepatocytes
Q55477337Overexpression of glia maturation factor in C6 cells promotes differentiation and activates superoxide dismutase.
Q34658898Oxidant-induced signaling: effects of peroxynitrite and singlet oxygen
Q41260199Oxidants as stimulators of signal transduction
Q33853144Oxidative stress and gene regulation
Q86630418Oxidative stress and superoxide dismutase in development, aging and gene regulation
Q36793896Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis
Q24308342PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase
Q46927975Parathyroid hormone induces mitogen-activated kinase phosphatase 1 in murine osteoblasts primarily through cAMP-protein kinase A signaling
Q40498677Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase
Q44064304Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
Q24337592Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
Q38331326Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1.
Q40249197Prostanoid- and interleukin-1-induced primary genes in cementoblastic cells
Q35540282Protein Phosphatases in Plants
Q42522435Protein kinase A balances the growth factor-induced Ras/ERK signaling
Q34483701Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression
Q42606695Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe
Q40017118Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.
Q71475516Protein tyrosine phosphatases and the control of cellular signaling responses
Q44133868Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion
Q36838436Purification and kinetic characterization of the mitogen-activated protein kinase phosphatase rVH6.
Q47348305Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast
Q33595625Redox regulation of cellular signalling
Q38343410Regulation of Drosophila MKP-3 by Drosophila ERK.
Q74001350Regulation of ERK2 dephosphorylation in G1-stimulated rat T lymphoblasts
Q44961788Regulation of c-Jun N-terminal kinase and p38 kinase pathways in endothelial cells
Q53777253Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.
Q28383512Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress
Q36389293Regulation of innate immune response by MAP kinase phosphatase-1
Q41109924Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells
Q34539377Regulation of stress-activated protein kinase signaling pathways by protein phosphatases
Q27932501Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases
Q41076956Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins
Q55027208Rlm1 mediates positive autoregulatory transcriptional feedback that is essential for Slt2-dependent gene expression.
Q41365375Role and regulation of MKP-1 in airway inflammation.
Q37365307Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy
Q45038622Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation
Q38613831Role of Protein Tyrosine Phosphatases in Plants
Q35101467Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway.
Q40884737Role of basal calcium in the EGF activation of MAP kinases
Q28140867Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
Q34001374S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes.
Q90026759SRXN1 Is Necessary for Resolution of GnRH-Induced Oxidative Stress and Induction of Gonadotropin Gene Expression
Q51764131Salivary RNA signatures in oral cancer detection.
Q34520902Sampling-dependent up-regulation of gene expression in sequential samples of human airway epithelial cells
Q24294660Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway
Q24317346Selective interaction of JNK protein kinase isoforms with transcription factors
Q34775192Sequential activation of ERK and repression of JNK by scatter factor/hepatocyte growth factor in madin-darby canine kidney epithelial cells
Q36884120Serum- and polypeptide growth factor-inducible gene expression in mouse fibroblasts.
Q34660270Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress
Q41750250Signal transduction through MAP kinase cascades
Q35375293Signaling pathways underlying the rapid antidepressant actions of ketamine
Q47925529Singlet molecular oxygen ((1)O2): a possible effector of eukaryotic gene expression
Q44448061Sodium arsenite retards proliferation of PHA-activated T cells by delaying the production and secretion of IL-2.
Q40618057Stimulated initiation of mitogen-activated protein kinase phosphatase-1 (MKP-1) gene transcription involves the synergistic action of multiple cis-acting elements in the proximal promoter
Q38358011Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.
Q34306493Strategies of antioxidant defense
Q41229276Stress proteins in the cellular response to ultraviolet radiation
Q41633407Structure and function of the low Mr phosphotyrosine protein phosphatases
Q36698072Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth
Q39695572Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer.
Q64445814Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc
Q34624894Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.
Q40722456Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IkappaBalpha in macrophages.
Q37514966Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis
Q34340221The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34.
Q40794535The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase
Q34271847The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching
Q28609800The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells
Q41297677The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence
Q48628440The alpha-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the alpha7 subunit
Q42522866The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity
Q41191937The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells
Q38288824The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.
Q54295087The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin.
Q40504212The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages
Q24562767The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase
Q57148178The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes
Q46195510The influence of diet on protein oxidation
Q33554478The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1
Q24309341The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
Q42553382The mitogenic effect of H2O2 for vascular smooth muscle cells is mediated by an increase of the affinity of basic fibroblast growth factor for its receptor
Q34419558The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation
Q41135262The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors
Q34728677The pattern of gene expression in human CD15+ myeloid progenitor cells
Q73101250The phorbol ester 12-O-tetradecanoylphorbol 13-acetate enhances the heat-induced stress response
Q38352009The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation
Q49076762The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization
Q33750116The role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases
Q42491851The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action
Q47070283The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis.
Q27930526The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA.
Q42469415Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists
Q28363102Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation
Q28581564Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect
Q37157244Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells
Q41886068Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo
Q77332320Upregulation of Jun and Fos family members and permanent JNK activity lead to constitutive AP-1 activation in Theileria-transformed leukocytes
Q64101131Weighted correlation network and differential expression analyses identify candidate genes associated with BRAF gene in melanoma
Q24316212XCL100, an inducible nuclear MAP kinase phosphatase from Xenopus laevis: Its role in MAP kinase inactivation in differentiated cells and its expression during early development
Q24321351Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease
Q40191106fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection
Q55434707l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1.
Q41360603p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.
Q40442820puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila

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