Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion

scientific article

Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M113.464792
P3181OpenCitations bibliographic resource ID3328649
P932PMC publication ID3711300
P698PubMed publication ID23720746
P5875ResearchGate publication ID236968911

P50authorLinya YouQ86440597
P2093author name stringLin Li
Xiang-Jiao Yang
Go-Woon Kim
Mohammad Ghorbani
P2860cites workMyc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell DifferentiationQ24294609
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylaseQ24296836
HDAC6 is a microtubule-associated deacetylaseQ24298013
MEC-17 is an alpha-tubulin acetyltransferaseQ24299301
Regulation of cellular metabolism by protein lysine acetylationQ24300091
Class II histone deacetylases: versatile regulatorsQ24300376
Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylationQ24300995
A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndromeQ24314944
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulinQ24324449
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant miceQ24338349
The many roles of histone deacetylases in development and physiology: implications for disease and therapyQ24628821
ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESISQ24629431
Lysine acetylation: codified crosstalk with other posttranslational modificationsQ24644959
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgeneQ24676918
Atomic resolution structure of human  -tubulin acetyltransferase bound to acetyl-CoAQ27674573
Crystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N TerminusQ27674774
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
The language of covalent histone modificationsQ27860931
Chromatin modifications and their functionQ27861067
Microtubule acetylation promotes kinesin-1 binding and transport.Q27919704
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normallyQ27919716
Systematic functional prioritization of protein posttranslational modificationsQ27936051
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensationQ28000035
The complex language of chromatin regulation during transcriptionQ28131748
Doublecortin is a microtubule-associated protein and is expressed widely by migrating neuronsQ28139253
Induction of neurogenesis in the neocortex of adult miceQ28139868
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and preventionQ28240437
Substrate and functional diversity of lysine acetylation revealed by a proteomics surveyQ28258445
Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling proteinQ28263735
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivoQ28482270
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivoQ28510434
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylationQ28585062
Post-translational modifications regulate microtubule functionQ29036830
The primary cilium: a signalling centre during vertebrate developmentQ29547197
Mechanisms and functional implications of adult neurogenesisQ29547295
Acetylation: a regulatory modification to rival phosphorylation?Q29614886
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic fluxQ29615102
New nomenclature for chromatin-modifying enzymesQ29616425
MEC-12, an alpha-tubulin required for touch sensitivity in C. elegansQ47069447
Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neuronsQ48168037
MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons.Q48379537
Induction of pluripotent stem cells from fibroblast culturesQ48770547
Eukaryotic domain of unknown function DUF738 belongs to Gcn5-related N-acetyltransferase superfamily.Q53582509
HDAC6 controls the kinetics of platelet activationQ61585845
Chlamydomonas alpha-tubulin is posttranslationally modified by acetylation on the epsilon-amino group of a lysineQ69940175
High level expression of nonacetylatable α‐tubulin in Chlamydomonas reinhardtiiQ72086395
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menQ29619117
Histone acetyltransferase complexes: one size doesn't fit allQ29620006
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
Tubulin acetyltransferase αTAT1 destabilizes microtubules independently of its acetylation activityQ30537332
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylationQ33526997
Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons.Q33647021
ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubulesQ34069992
Exploring the yeast acetylome using functional genomicsQ34111422
Loss of deacetylation activity of Hdac6 affects emotional behavior in miceQ34157277
Functional significance of histone deacetylase diversityQ34183839
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functionsQ34232911
Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammationQ34236680
Identification of an acetylation site of Chlamydomonas alpha-tubulinQ34338575
Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubulesQ34461085
Deacetylase enzymes: biological functions and the use of small-molecule inhibitorsQ34528043
Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organizationQ36055162
Cytoplasmic microtubules containing acetylated alpha-tubulin in Chlamydomonas reinhardtii: spatial arrangement and propertiesQ36213095
Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organismsQ36213951
Microtubules containing acetylated alpha-tubulin in mammalian cells in cultureQ36215921
Individual microtubules in the axon consist of domains that differ in both composition and stabilityQ36223418
The initiation of neurite outgrowth by sympathetic neurons grown in vitro does not depend on assembly of microtubulesQ36234856
Microtubule stabilization specifies initial neuronal polarizationQ36446628
Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubulesQ36894917
Cross-regulation of histone modificationsQ36994157
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coliQ37080670
Post-translational modifications of tubulin in the nervous systemQ37403762
Facilitating axon regeneration in the injured CNS by microtubules stabilization.Q37941706
Mechanism of microtubule stabilization by doublecortinQ38575732
The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylasesQ39197659
Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylasesQ39214537
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.Q39802173
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylationQ40152899
Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation.Q40324916
Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblastsQ41377311
Acetylation of lysine 40 in alpha-tubulin is not essential in Tetrahymena thermophilaQ42771369
Cell biology: Tubulin acetylation and cell motilityQ42806332
A single amino-acid substitution at lysine 40 of an Arabidopsis thalianaα-tubulin causes extensive cell proliferation and expansion defects.Q43924854
N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development.Q46193500
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
Alpha tubulin acetyltransferase 1Q21116742
Alpha tubulin acetyltransferase 1Q21983531
P304page(s)20334-20350
P577publication date2013-05-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleMice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion
P478volume288

Reverse relations

cites work (P2860)
Q35507882A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis
Q92384515ATAT1-enriched vesicles promote microtubule acetylation via axonal transport
Q48473545Adrenalectomy facilitates ATAT1 expression and α-tubulin acetylation in ACTH-producing corticotrophs
Q59799503Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption
Q90639155Axonal transport: Driving synaptic function
Q37285259Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia
Q89281684Coordination of microtubule acetylation and the actin cytoskeleton by formins
Q34457162Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.
Q35485464Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice
Q88990440Dynamic localization of α-tubulin acetyltransferase ATAT1 through the cell cycle in human fibroblastic KD cells
Q47419187Effects of mutating α-tubulin lysine 40 on sensory dendrite development.
Q33688273Effects of αTAT1 and HDAC5 on axonal regeneration in adult neurons.
Q60953054Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer
Q33784606Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos.
Q64102997HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke
Q42486628Intracellular localization of α-tubulin acetyltransferase ATAT1 in rat ciliated cells.
Q38259350Intrinsically disordered tubulin tails: complex tuners of microtubule functions?
Q33709311Longevity pathways and memory aging
Q57796361Microtubule Acetylation Is Required for Mechanosensation in Drosophila
Q38979974Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production
Q27324158Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
Q36298070New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry
Q37412510Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
Q35132313Post-translational modifications of tubulin: pathways to functional diversity of microtubules
Q39047528Posttranslational Modifications of Tubulin and Cilia
Q39314105Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration
Q53224985Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome.
Q52606307Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning.
Q61813218Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub
Q52716095TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.
Q88763807TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation
Q28834427TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii
Q34505489The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival
Q39007123The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency
Q48268412The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression
Q28638824The biological functions of Naa10 - From amino-terminal acetylation to human disease
Q34467243The chromatin regulator Brpf1 regulates embryo development and cell proliferation
Q39001599The elongation of primary cilia via the acetylation of α-tubulin by the treatment with lithium chloride in human fibroblast KD cells
Q26744292The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target
Q89927140The tubulin code and its role in controlling microtubule properties and functions
Q48168609Tubulin acetylation: A novel functional avenue for CDYL in sperm.
Q34487624Tubulin acetylation: responsible enzymes, biological functions and human diseases
Q104482079Tubulin post-translational modifications control neuronal development and functions
Q30432171Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion
Q48088261α-Tubulin Acetylation Restricts Axon Overbranching by Dampening Microtubule Plus-End Dynamics in Neurons
Q51745472α-Tubulin Acetyltransferase Is a Novel Target Mediating Neurite Growth Inhibitory Effects of Chondroitin Sulfate Proteoglycans and Myelin-Associated Glycoprotein.
Q37164264αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells
Q42912918αTAT1: a potential therapeutic target in cancer?

Search more.