scholarly article | Q13442814 |
P50 | author | Ludger Hengst | Q67994075 |
P2093 | author name string | C Weinl | |
H Jäkel | |||
P2860 | cites work | p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation | Q39861323 |
Tyrosine phosphatase SHP-2 is a regulator of p27(Kip1) tyrosine phosphorylation | Q39907432 | ||
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4 | Q39949579 | ||
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. | Q40123526 | ||
Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression. | Q40259890 | ||
Activated Jak2 with the V617F point mutation promotes G1/S phase transition | Q40288678 | ||
Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. | Q40367275 | ||
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase | Q40559879 | ||
Translational control of p27Kip1 accumulation during the cell cycle | Q41213467 | ||
p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. | Q42277847 | ||
Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation | Q43115388 | ||
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor | Q43948616 | ||
Interleukin 3 and cell cycle progression | Q70289646 | ||
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases | Q24294546 | ||
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 | Q24294568 | ||
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex | Q24295120 | ||
New functional activities for the p21 family of CDK inhibitors | Q24313427 | ||
Cell cycle, CDKs and cancer: a changing paradigm | Q24314465 | ||
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin | Q24318979 | ||
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis | Q24540387 | ||
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop | Q24646491 | ||
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer | Q24648025 | ||
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera | Q28241887 | ||
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex | Q28249855 | ||
Jak2 is essential for signaling through a variety of cytokine receptors | Q28270987 | ||
The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain | Q28302928 | ||
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis | Q29614337 | ||
Cyclin-dependent kinases: engines, clocks, and microprocessors | Q29614786 | ||
A gain-of-function mutation of JAK2 in myeloproliferative disorders | Q29618851 | ||
Identification of an acquired JAK2 mutation in polycythemia vera | Q33947635 | ||
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy | Q34763495 | ||
A cell cycle-regulated inhibitor of cyclin-dependent kinases | Q35428836 | ||
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression? | Q36385618 | ||
Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity | Q36421097 | ||
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes | Q36508949 | ||
The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition | Q36583525 | ||
JAK-2 mutations and their relevance to myeloproliferative disease | Q36667635 | ||
Jak2: normal function and role in hematopoietic disorders | Q36701568 | ||
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease | Q36843762 | ||
Hematopoietic cytokine receptor signaling | Q36970188 | ||
Therapeutic potential of JAK2 inhibitors | Q37653313 | ||
P4510 | describes a project that uses | ImageQuant | Q112270642 |
P433 | issue | 32 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | phosphorylation | Q242736 |
Janus kinase 2 | Q14914518 | ||
P304 | page(s) | 3502-3512 | |
P577 | publication date | 2011-03-21 | |
P1433 | published in | Oncogene | Q1568657 |
P1476 | title | Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control | |
P478 | volume | 30 |
Q38773853 | A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27(Kip1)) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells |
Q28115769 | Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4 |
Q27309926 | Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion |
Q89481046 | Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis |
Q35958293 | Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation |
Q41230366 | FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia |
Q35018620 | Genome-scale identification and characterization of moonlighting proteins |
Q36285745 | JAK Kinases in Health and Disease: An Update |
Q91809296 | JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death |
Q38684435 | JAK2 inhibitors for myeloproliferative neoplasms: what is next? |
Q37168138 | JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms |
Q37926574 | JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth |
Q42536043 | Mechanism of cell cycle entry mediated by the intrinsically disordered protein p27(Kip1). |
Q92602221 | Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis |
Q43207235 | P27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases |
Q38775916 | Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer |
Q37421820 | Redox regulation of Janus kinase: The elephant in the room |
Q28540246 | Reduced expression of the retinoblastoma protein shows that the related signaling pathway is essential for mediating the antineoplastic activity of erufosine |
Q37580422 | Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells |
Q37739542 | Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity |
Q26860796 | Targeting JAK2 in the therapy of myeloproliferative neoplasms |
Q94452173 | The CDK inhibitor p57Kip2 enhances the activity of the transcriptional coactivator FHL2 |
Q34979711 | The activity and stability of the intrinsically disordered Cip/Kip protein family are regulated by non-receptor tyrosine kinases |
Q39116900 | The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells. |
Q50285968 | Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus |
Q50285967 | Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes |
Q36385784 | Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. |
Q38247694 | p27 and leukemia: cell cycle and beyond |
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