Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

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Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046862404
P356DOI10.1038/ONC.2011.68
P3181OpenCitations bibliographic resource ID4604639
P932PMC publication ID3160490
P698PubMed publication ID21423214
P5875ResearchGate publication ID50596746

P50authorLudger HengstQ67994075
P2093author name stringC Weinl
H Jäkel
P2860cites workp27 deregulation by Skp2 overexpression induced by the JAK2V617 mutationQ39861323
Tyrosine phosphatase SHP-2 is a regulator of p27(Kip1) tyrosine phosphorylationQ39907432
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4Q39949579
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.Q40123526
Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression.Q40259890
Activated Jak2 with the V617F point mutation promotes G1/S phase transitionQ40288678
Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.Q40367275
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinaseQ40559879
Translational control of p27Kip1 accumulation during the cell cycleQ41213467
p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.Q42277847
Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturationQ43115388
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitorQ43948616
Interleukin 3 and cell cycle progressionQ70289646
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinasesQ24294546
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2Q24294568
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
New functional activities for the p21 family of CDK inhibitorsQ24313427
Cell cycle, CDKs and cancer: a changing paradigmQ24314465
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatinQ24318979
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisQ24540387
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loopQ24646491
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraQ28241887
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complexQ28249855
Jak2 is essential for signaling through a variety of cytokine receptorsQ28270987
The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chainQ28302928
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosisQ29614337
Cyclin-dependent kinases: engines, clocks, and microprocessorsQ29614786
A gain-of-function mutation of JAK2 in myeloproliferative disordersQ29618851
Identification of an acquired JAK2 mutation in polycythemia veraQ33947635
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapyQ34763495
A cell cycle-regulated inhibitor of cyclin-dependent kinasesQ35428836
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?Q36385618
Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activityQ36421097
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenesQ36508949
The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibitionQ36583525
JAK-2 mutations and their relevance to myeloproliferative diseaseQ36667635
Jak2: normal function and role in hematopoietic disordersQ36701568
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative diseaseQ36843762
Hematopoietic cytokine receptor signalingQ36970188
Therapeutic potential of JAK2 inhibitorsQ37653313
P4510describes a project that usesImageQuantQ112270642
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
Janus kinase 2Q14914518
P304page(s)3502-3512
P577publication date2011-03-21
P1433published inOncogeneQ1568657
P1476titlePhosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control
P478volume30

Reverse relations

cites work (P2860)
Q38773853A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27(Kip1)) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells
Q28115769Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4
Q27309926Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion
Q89481046Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis
Q35958293Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation
Q41230366FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia
Q35018620Genome-scale identification and characterization of moonlighting proteins
Q36285745JAK Kinases in Health and Disease: An Update
Q91809296JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death
Q38684435JAK2 inhibitors for myeloproliferative neoplasms: what is next?
Q37168138JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Q37926574JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth
Q42536043Mechanism of cell cycle entry mediated by the intrinsically disordered protein p27(Kip1).
Q92602221Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Q43207235P27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases
Q38775916Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer
Q37421820Redox regulation of Janus kinase: The elephant in the room
Q28540246Reduced expression of the retinoblastoma protein shows that the related signaling pathway is essential for mediating the antineoplastic activity of erufosine
Q37580422Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells
Q37739542Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity
Q26860796Targeting JAK2 in the therapy of myeloproliferative neoplasms
Q94452173The CDK inhibitor p57Kip2 enhances the activity of the transcriptional coactivator FHL2
Q34979711The activity and stability of the intrinsically disordered Cip/Kip protein family are regulated by non-receptor tyrosine kinases
Q39116900The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells.
Q50285968Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
Q50285967Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
Q36385784Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.
Q38247694p27 and leukemia: cell cycle and beyond

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