p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor

scientific article

p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor is …
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scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/21.11.2724
P3181OpenCitations bibliographic resource ID2427421
P932PMC publication ID126028
P698PubMed publication ID12032085
P5875ResearchGate publication ID11340601

P2093author name stringAlbrecht Bindereif
Silke Schreiner
Andrey Damianov
Ram Reddy
Mathias Bell
P2860cites workA doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitroQ22010663
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formationQ24291494
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicingQ24292373
SMART: a web-based tool for the study of genetically mobile domainsQ24515301
Specificity of Prp24 binding to RNA: a role for Prp24 in the dynamic interaction of U4 and U6 snRNAsQ24539044
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPsQ24539227
Multiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangementsQ24548079
Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAsQ24568354
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragmentQ27629324
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2Q27930438
Yeast pre-mRNA splicing requires a pair of U1 snRNP-associated tetratricopeptide repeat proteinsQ27930517
A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particlesQ27931035
The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2pQ27935715
Genome-wide protein interaction screens reveal functional networks involving Sm-like proteinsQ27938720
Expression of tumor-rejection antigens in gynecologic cancersQ28138549
Mouse homologue of the human SART3 gene encoding tumor-rejection antigenQ28141597
Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patientsQ28143032
The tetratricopeptide repeat: a structural motif mediating protein-protein interactionsQ28145758
Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifsQ28268698
Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1Q28275216
Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patientsQ28361963
Protein functions in pre-mRNA splicingQ29620262
RNA editing and alternative splicing generate mRNA transcript diversity from the Drosophila 4f-rnp locusQ32141752
An abundant U6 snRNP found in germ cells and embryos of Xenopus laevisQ33590688
An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assemblyQ33929483
Association of the lupus antigen La with a subset of U6 snRNA moleculesQ36139604
Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particlesQ36783515
3'-end-dependent formation of U6 small nuclear ribonucleoprotein particles in Xenopus laevis oocyte nucleiQ36818931
Conserved domains of human U4 snRNA required for snRNP and spliceosome assemblyQ38338358
Cloning and mutational analysis of the Leptomonas seymouri U5 snRNA gene: function of the Sm site in core RNP formation and nuclear localizationQ39729249
Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexesQ41201011
Reconstituted mammalian U4/U6 snRNP complements splicing: a mutational analysisQ41514813
Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNPQ42625366
Isolation and characterization of a new 110 kDa human nuclear RNA-binding protein (p110nrb).Q48029070
The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genesQ48222889
A gene associated with filamentous growth in Ophiostoma novo-ulmi has RNA-binding motifs and is similar to a yeast gene involved in mRNA splicing.Q52538582
The HAT helix, a repetitive motif implicated in RNA processing.Q52561891
RNA-protein organization of U1, U5 and U4-U6 small nuclear ribonucleoproteins in HeLa cells.Q54426551
Expression of SART3 tumor-rejection antigen in gastric cancers.Q55221794
Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitroQ70196254
Purification of human U6 small nuclear RNA capping enzyme. Evidence for a common capping enzyme for gamma-monomethyl-capped small RNAsQ72403407
Conformational changes of U6 RNA during the spliceosome cycle: an intramolecular helix is essential both for initiating the U4-U6 interaction and for the first step of slicingQ72829857
Identification of SART3-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with different HLA-A2 subtypesQ73141847
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectSpliceosome associated factor 3, U4/U6 recycling proteinQ21121239
P304page(s)2724-2735
P577publication date2002-06-01
P1433published inThe EMBO JournalQ1278554
P1476titlep110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor
P478volume21

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cites work (P2860)
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Q24306552Identification of a PRPF4 loss-of-function variant that abrogates U4/U6.U5 tri-snRNP integration and is associated with retinitis pigmentosa
Q24294457Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase
Q35121375In vivo kinetics of Cajal body components
Q30498165In vivo kinetics of U4/U6·U5 tri-snRNP formation in Cajal bodies.
Q35800268Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110.
Q24336921Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies
Q34365152RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts
Q34993977RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation
Q24299534RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies
Q30277623Recurrent chimeric fusion RNAs in non-cancer tissues and cells.
Q24306575Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP
Q34130110Ribonucleoprotein multimers and their functions
Q40950182SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
Q37546093Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis
Q33829070Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis
Q42335063Specific genomic cues regulate Cajal body assembly
Q38629976Spliceosomal small nuclear ribonucleoprotein particles repeatedly cycle through Cajal bodies
Q35534989Spliceosome assembly in the absence of stable U4/U6 RNA pairing
Q27676636Structural basis for dual roles of Aar2p in U5 snRNP assembly
Q42598430Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3.
Q36588912Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly
Q27660041Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24
Q24681912Structure and interactions of the first three RNA recognition motifs of splicing factor prp24
Q24652376Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy
Q24321455Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme
Q24298315TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC
Q24294504Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies
Q34425050The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.
Q36436723The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze
Q24537424The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding
Q24337075The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome
Q24337279The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination
Q36972150The assembly of a spliceosomal small nuclear ribonucleoprotein particle
Q37843675The function of spliceosome components in open mitosis
Q33455467The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
Q24300349The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation
Q48172115The life of U6 small nuclear RNA, from cradle to grave
Q35237097The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling
Q48242160Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2.
Q41093951Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing
Q34791447Tip110 interacts with YB-1 and regulates each other's function.
Q37428613Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription
Q36323286U4 snRNA nucleolar localization requires the NHPX/15.5-kD protein binding site but not Sm protein or U6 snRNA association
Q38115287U6 RNA biogenesis and disease association
Q33635877USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.

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